"Guanidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
| Descriptor ID |
D019791
|
| MeSH Number(s) |
D02.078.370.472
|
| Concept/Terms |
Guanidine Hydrochloride- Guanidine Hydrochloride
- Hydrochloride, Guanidine
- Guanidinium Chloride
- Chloride, Guanidinium
- Guanidium Chloride
- Chloride, Guanidium
- Guanidine Monohydrochloride
- Monohydrochloride, Guanidine
|
Below are MeSH descriptors whose meaning is more general than "Guanidine".
Below are MeSH descriptors whose meaning is more specific than "Guanidine".
This graph shows the total number of publications written about "Guanidine" by people in this website by year, and whether "Guanidine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Guanidine" by people in Profiles.
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Methylglyoxal Forms Diverse Mercaptomethylimidazole Crosslinks with Thiol and Guanidine Pairs in Endogenous Metabolites and Proteins. ACS Chem Biol. 2021 11 19; 16(11):2453-2461.
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Observations on the Effects of Residualization and Dehalogenation on the Utility of N-Succinimidyl Ester Acylation Agents for Radioiodination of the Internalizing Antibody Trastuzumab. Molecules. 2019 Oct 30; 24(21).
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Random coil negative control reproduces the discrepancy between scattering and FRET measurements of denatured protein dimensions. Proc Natl Acad Sci U S A. 2015 May 26; 112(21):6631-6.
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In vitro evaluation of guanidine analogs as sigma receptor ligands for potential anti-stroke therapeutics. J Pharmacol Exp Ther. 2013 Jan; 344(1):155-66.
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Small-angle X-ray scattering and single-molecule FRET spectroscopy produce highly divergent views of the low-denaturant unfolded state. J Mol Biol. 2012 May 04; 418(3-4):226-36.
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Comparative molecular dynamics simulation studies of protegrin-1 monomer and dimer in two different lipid bilayers. Biophys J. 2009 Aug 05; 97(3):787-95.
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Quantifying the structural requirements of the folding transition state of protein A and other systems. J Mol Biol. 2008 Sep 19; 381(5):1362-81.
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Random-coil behavior and the dimensions of chemically unfolded proteins. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12491-6.
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Evidence for a proinflammatory and proteolytic environment in plaques from endarterectomy segments of human carotid arteries. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):129-35.
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D/H amide isotope effect in model alpha-helical peptides. J Am Chem Soc. 2002 Nov 27; 124(47):13994-5.