 Hemangioma, Cavernous, Central Nervous System
"Hemangioma, Cavernous, Central Nervous System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vascular anomaly composed of a collection of large, thin walled tortuous VEINS that can occur in any part of the central nervous system but lack intervening nervous tissue. Familial occurrence is common and has been associated with a number of genes mapped to 7q, 7p and 3q. Clinical features include SEIZURES; HEADACHE; STROKE; and progressive neurological deficit.
| Descriptor ID |
D020786
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| MeSH Number(s) |
C04.557.645.375.385.500 C10.500.190.200 C14.240.850.875.249 C14.907.454.385.500 C15.378.463.515.385.500 C16.131.666.190.200
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| Concept/Terms |
Cerebral Cavernous Hemangioma- Cerebral Cavernous Hemangioma
- Cavernous Hemangioma, Cerebral
- Cavernous Hemangiomas, Cerebral
- Cerebral Cavernous Hemangiomas
- Hemangioma, Cerebral Cavernous
- Hemangiomas, Cerebral Cavernous
Cavernous Hemangioma, Extracerebral- Cavernous Hemangioma, Extracerebral
- Cavernous Hemangiomas, Extracerebral
- Extracerebral Cavernous Hemangioma
- Extracerebral Cavernous Hemangiomas
- Hemangioma, Extracerebral Cavernous
- Hemangiomas, Extracerebral Cavernous
Cavernous Hemangioma, Intracerebral- Cavernous Hemangioma, Intracerebral
- Cavernous Hemangiomas, Intracerebral
- Hemangioma, Intracerebral Cavernous
- Hemangiomas, Intracerebral Cavernous
- Intracerebral Cavernous Hemangioma
- Intracerebral Cavernous Hemangiomas
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Below are MeSH descriptors whose meaning is more general than "Hemangioma, Cavernous, Central Nervous System".
- Diseases [C]
- Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
- Neoplasms, Vascular Tissue [C04.557.645]
- Hemangioma [C04.557.645.375]
- Hemangioma, Cavernous [C04.557.645.375.385]
- Hemangioma, Cavernous, Central Nervous System [C04.557.645.375.385.500]
- Nervous System Diseases [C10]
- Nervous System Malformations [C10.500]
- Central Nervous System Vascular Malformations [C10.500.190]
- Hemangioma, Cavernous, Central Nervous System [C10.500.190.200]
- Cardiovascular Diseases [C14]
- Cardiovascular Abnormalities [C14.240]
- Vascular Malformations [C14.240.850]
- Central Nervous System Vascular Malformations [C14.240.850.875]
- Hemangioma, Cavernous, Central Nervous System [C14.240.850.875.249]
- Vascular Diseases [C14.907]
- Hemostatic Disorders [C14.907.454]
- Hemangioma, Cavernous [C14.907.454.385]
- Hemangioma, Cavernous, Central Nervous System [C14.907.454.385.500]
- Hemic and Lymphatic Diseases [C15]
- Hematologic Diseases [C15.378]
- Hemorrhagic Disorders [C15.378.463]
- Hemostatic Disorders [C15.378.463.515]
- Hemangioma, Cavernous [C15.378.463.515.385]
- Hemangioma, Cavernous, Central Nervous System [C15.378.463.515.385.500]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Congenital Abnormalities [C16.131]
- Nervous System Malformations [C16.131.666]
- Central Nervous System Vascular Malformations [C16.131.666.190]
- Hemangioma, Cavernous, Central Nervous System [C16.131.666.190.200]
Below are MeSH descriptors whose meaning is more specific than "Hemangioma, Cavernous, Central Nervous System".
This graph shows the total number of publications written about "Hemangioma, Cavernous, Central Nervous System" by people in this website by year, and whether "Hemangioma, Cavernous, Central Nervous System" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2000 | 1 | 0 | 1 | | 2004 | 1 | 1 | 2 | | 2005 | 2 | 0 | 2 | | 2006 | 3 | 0 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 2 | 0 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 4 | 1 | 5 | | 2011 | 2 | 0 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 4 | 0 | 4 | | 2015 | 1 | 0 | 1 | | 2016 | 7 | 0 | 7 | | 2017 | 4 | 0 | 4 | | 2018 | 4 | 0 | 4 | | 2019 | 6 | 0 | 6 | | 2020 | 7 | 0 | 7 | | 2021 | 9 | 0 | 9 |
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Below are the most recent publications written about "Hemangioma, Cavernous, Central Nervous System" by people in Profiles.
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Kim H, Flemming KD, Nelson JA, Lui A, Majersik JJ, Cruz MD, Zabramski J, Trevizo O, Lanzino G, Zafar A, Torbey M, Mabray MC, Robinson M, Narvid J, Lupo J, Thompson RE, Hanley DF, McBee N, Treine K, Ostapkovich N, Stadnik A, Piedad K, Hobson N, Carroll T, Shkoukani A, Carrión-Penagos J, Mendoza-Puccini C, Koenig JI, Awad I. Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project. Stroke. 2021 12; 52(12):3829-3838.
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Awad IA. Commentary: Feasibility and Morbidity of Magnetic Resonance Imaging-Guided Stereotactic Laser Ablation of Deep Cerebral Cavernous Malformations: A Report of 4 Cases. Neurosurgery. 2021 09 15; 89(4):E207-E208.
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Shkoukani A, Srinath A, Stadnik A, Girard R, Shenkar R, Sheline A, Dahlem K, Lee C, Flemming K, Awad IA. COVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation. J Stroke Cerebrovasc Dis. 2021 Nov; 30(11):106101.
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Lopez-Ramirez MA, Lai CC, Soliman SI, Hale P, Pham A, Estrada EJ, McCurdy S, Girard R, Verma R, Moore T, Lightle R, Hobson N, Shenkar R, Poulsen O, Haddad GG, Daneman R, Gongol B, Sun H, Lagarrigue F, Awad IA, Ginsberg MH. Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. J Clin Invest. 2021 07 01; 131(13).
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Snellings DA, Hong CC, Ren AA, Lopez-Ramirez MA, Girard R, Srinath A, Marchuk DA, Ginsberg MH, Awad IA, Kahn ML. Cerebral Cavernous Malformation: From Mechanism to Therapy. Circ Res. 2021 06 25; 129(1):195-215.
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Li W, Tran V, Shaked I, Xue B, Moore T, Lightle R, Kleinfeld D, Awad IA, Ginsberg MH. Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations. Elife. 2021 05 20; 10.
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Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Müller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert JM, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn ML. PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. Nature. 2021 06; 594(7862):271-276.
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Girard R, Li Y, Stadnik A, Shenkar R, Hobson N, Romanos S, Srinath A, Moore T, Lightle R, Shkoukani A, Akers A, Carroll T, Christoforidis GA, Koenig JI, Lee C, Piedad K, Greenberg SM, Kim H, Flemming KD, Ji Y, Awad IA. A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH). Neurosurgery. 2021 02 16; 88(3):686-697.
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Li W, Shenkar R, Detter MR, Moore T, Benavides C, Lightle R, Girard R, Hobson N, Cao Y, Li Y, Griffin E, Gallione C, Zabramski JM, Ginsberg MH, Marchuk DA, Awad IA. Propranolol inhibits cavernous vascular malformations by ß1 adrenergic receptor antagonism in animal models. J Clin Invest. 2021 02 01; 131(3).
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Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn ML. Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. J Exp Med. 2020 10 05; 217(10).
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