 Hemangioma, Cavernous, Central Nervous System
"Hemangioma, Cavernous, Central Nervous System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vascular anomaly composed of a collection of large, thin walled tortuous VEINS that can occur in any part of the central nervous system but lack intervening nervous tissue. Familial occurrence is common and has been associated with a number of genes mapped to 7q, 7p and 3q. Clinical features include SEIZURES; HEADACHE; STROKE; and progressive neurological deficit.
| Descriptor ID |
D020786
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| MeSH Number(s) |
C04.557.645.375.385.500 C10.500.190.200 C14.240.850.875.249 C14.907.454.385.500 C15.378.463.515.385.500 C16.131.666.190.200
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| Concept/Terms |
Cerebral Cavernous Hemangioma- Cerebral Cavernous Hemangioma
- Cavernous Hemangioma, Cerebral
- Cavernous Hemangiomas, Cerebral
- Cerebral Cavernous Hemangiomas
- Hemangioma, Cerebral Cavernous
- Hemangiomas, Cerebral Cavernous
Cavernous Hemangioma, Extracerebral- Cavernous Hemangioma, Extracerebral
- Cavernous Hemangiomas, Extracerebral
- Extracerebral Cavernous Hemangioma
- Extracerebral Cavernous Hemangiomas
- Hemangioma, Extracerebral Cavernous
- Hemangiomas, Extracerebral Cavernous
Cavernous Hemangioma, Intracerebral- Cavernous Hemangioma, Intracerebral
- Cavernous Hemangiomas, Intracerebral
- Hemangioma, Intracerebral Cavernous
- Hemangiomas, Intracerebral Cavernous
- Intracerebral Cavernous Hemangioma
- Intracerebral Cavernous Hemangiomas
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Below are MeSH descriptors whose meaning is more general than "Hemangioma, Cavernous, Central Nervous System".
- Diseases [C]
- Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
- Neoplasms, Vascular Tissue [C04.557.645]
- Hemangioma [C04.557.645.375]
- Hemangioma, Cavernous [C04.557.645.375.385]
- Hemangioma, Cavernous, Central Nervous System [C04.557.645.375.385.500]
- Nervous System Diseases [C10]
- Nervous System Malformations [C10.500]
- Central Nervous System Vascular Malformations [C10.500.190]
- Hemangioma, Cavernous, Central Nervous System [C10.500.190.200]
- Cardiovascular Diseases [C14]
- Cardiovascular Abnormalities [C14.240]
- Vascular Malformations [C14.240.850]
- Central Nervous System Vascular Malformations [C14.240.850.875]
- Hemangioma, Cavernous, Central Nervous System [C14.240.850.875.249]
- Vascular Diseases [C14.907]
- Hemostatic Disorders [C14.907.454]
- Hemangioma, Cavernous [C14.907.454.385]
- Hemangioma, Cavernous, Central Nervous System [C14.907.454.385.500]
- Hemic and Lymphatic Diseases [C15]
- Hematologic Diseases [C15.378]
- Hemorrhagic Disorders [C15.378.463]
- Hemostatic Disorders [C15.378.463.515]
- Hemangioma, Cavernous [C15.378.463.515.385]
- Hemangioma, Cavernous, Central Nervous System [C15.378.463.515.385.500]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Congenital Abnormalities [C16.131]
- Nervous System Malformations [C16.131.666]
- Central Nervous System Vascular Malformations [C16.131.666.190]
- Hemangioma, Cavernous, Central Nervous System [C16.131.666.190.200]
Below are MeSH descriptors whose meaning is more specific than "Hemangioma, Cavernous, Central Nervous System".
This graph shows the total number of publications written about "Hemangioma, Cavernous, Central Nervous System" by people in this website by year, and whether "Hemangioma, Cavernous, Central Nervous System" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2004 | 1 | 1 | 2 | | 2005 | 2 | 0 | 2 | | 2006 | 3 | 0 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 2 | 0 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 4 | 1 | 5 | | 2011 | 2 | 0 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 4 | 0 | 4 | | 2015 | 1 | 0 | 1 | | 2016 | 7 | 0 | 7 | | 2017 | 4 | 0 | 4 | | 2018 | 4 | 0 | 4 | | 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Hemangioma, Cavernous, Central Nervous System" by people in Profiles.
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Chapman EM, Lant B, Ohashi Y, Yu B, Schertzberg M, Go C, Dogra D, Koskimäki J, Girard R, Li Y, Fraser AG, Awad IA, Abdelilah-Seyfried S, Gingras AC, Derry WB. A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis. Nat Commun. 2019 04 17; 10(1):1791.
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Shenkar R, Peiper A, Pardo H, Moore T, Lightle R, Girard R, Hobson N, Polster SP, Koskimäki J, Zhang D, Lyne SB, Cao Y, Chaudagar K, Saadat L, Gallione C, Pytel P, Liao JK, Marchuk D, Awad IA. Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. Stroke. 2019 03; 50(3):738-744.
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Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood. 2019 01 17; 133(3):193-204.
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Wang Y, Li Y, Zou J, Polster SP, Lightle R, Moore T, Dimaano M, He TC, Weber CR, Awad IA, Shen L. The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation. FASEB J. 2019 02; 33(2):2132-2143.
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Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Koskimäki J, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IA. Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019 03; 99(3):319-330.
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Girard R, Zeineddine HA, Koskimäki J, Fam MD, Cao Y, Shi C, Moore T, Lightle R, Stadnik A, Chaudagar K, Polster S, Shenkar R, Duggan R, Leclerc D, Whitehead KJ, Li DY, Awad IA. Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth. Circ Res. 2018 06 08; 122(12):1716-1721.
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Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 06; 214(11):3331-3346.
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Girard R, Zeineddine HA, Fam MD, Mayampurath A, Cao Y, Shi C, Shenkar R, Polster SP, Jesselson M, Duggan R, Mikati AG, Christoforidis G, Andrade J, Whitehead KJ, Li DY, Awad IA. Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations. Transl Stroke Res. 2018 02; 9(1):34-43.
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Zeineddine HA, Girard R, Cao Y, Hobson N, Fam MD, Stadnik A, Tan H, Shen J, Chaudagar K, Shenkar R, Thompson RE, McBee N, Hanley D, Carroll T, Christoforidis GA, Awad IA. Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage. J Magn Reson Imaging. 2018 04; 47(4):1133-1138.
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Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML. Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature. 2017 05 18; 545(7654):305-310.
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