 Hemangioma, Cavernous, Central Nervous System
"Hemangioma, Cavernous, Central Nervous System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vascular anomaly composed of a collection of large, thin walled tortuous VEINS that can occur in any part of the central nervous system but lack intervening nervous tissue. Familial occurrence is common and has been associated with a number of genes mapped to 7q, 7p and 3q. Clinical features include SEIZURES; HEADACHE; STROKE; and progressive neurological deficit.
| Descriptor ID |
D020786
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| MeSH Number(s) |
C04.557.645.375.385.500 C10.500.190.200 C14.240.850.875.249 C14.907.454.385.500 C15.378.463.515.385.500 C16.131.666.190.200
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| Concept/Terms |
Cerebral Cavernous Hemangioma- Cerebral Cavernous Hemangioma
- Cavernous Hemangioma, Cerebral
- Cavernous Hemangiomas, Cerebral
- Cerebral Cavernous Hemangiomas
- Hemangioma, Cerebral Cavernous
- Hemangiomas, Cerebral Cavernous
Cavernous Hemangioma, Extracerebral- Cavernous Hemangioma, Extracerebral
- Cavernous Hemangiomas, Extracerebral
- Extracerebral Cavernous Hemangioma
- Extracerebral Cavernous Hemangiomas
- Hemangioma, Extracerebral Cavernous
- Hemangiomas, Extracerebral Cavernous
Cavernous Hemangioma, Intracerebral- Cavernous Hemangioma, Intracerebral
- Cavernous Hemangiomas, Intracerebral
- Hemangioma, Intracerebral Cavernous
- Hemangiomas, Intracerebral Cavernous
- Intracerebral Cavernous Hemangioma
- Intracerebral Cavernous Hemangiomas
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Below are MeSH descriptors whose meaning is more general than "Hemangioma, Cavernous, Central Nervous System".
- Diseases [C]
- Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
- Neoplasms, Vascular Tissue [C04.557.645]
- Hemangioma [C04.557.645.375]
- Hemangioma, Cavernous [C04.557.645.375.385]
- Hemangioma, Cavernous, Central Nervous System [C04.557.645.375.385.500]
- Nervous System Diseases [C10]
- Nervous System Malformations [C10.500]
- Central Nervous System Vascular Malformations [C10.500.190]
- Hemangioma, Cavernous, Central Nervous System [C10.500.190.200]
- Cardiovascular Diseases [C14]
- Cardiovascular Abnormalities [C14.240]
- Vascular Malformations [C14.240.850]
- Central Nervous System Vascular Malformations [C14.240.850.875]
- Hemangioma, Cavernous, Central Nervous System [C14.240.850.875.249]
- Vascular Diseases [C14.907]
- Hemostatic Disorders [C14.907.454]
- Hemangioma, Cavernous [C14.907.454.385]
- Hemangioma, Cavernous, Central Nervous System [C14.907.454.385.500]
- Hemic and Lymphatic Diseases [C15]
- Hematologic Diseases [C15.378]
- Hemorrhagic Disorders [C15.378.463]
- Hemostatic Disorders [C15.378.463.515]
- Hemangioma, Cavernous [C15.378.463.515.385]
- Hemangioma, Cavernous, Central Nervous System [C15.378.463.515.385.500]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Congenital Abnormalities [C16.131]
- Nervous System Malformations [C16.131.666]
- Central Nervous System Vascular Malformations [C16.131.666.190]
- Hemangioma, Cavernous, Central Nervous System [C16.131.666.190.200]
Below are MeSH descriptors whose meaning is more specific than "Hemangioma, Cavernous, Central Nervous System".
This graph shows the total number of publications written about "Hemangioma, Cavernous, Central Nervous System" by people in this website by year, and whether "Hemangioma, Cavernous, Central Nervous System" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2004 | 1 | 1 | 2 | | 2005 | 2 | 0 | 2 | | 2006 | 3 | 0 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 2 | 0 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 4 | 1 | 5 | | 2011 | 2 | 0 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 4 | 0 | 4 | | 2015 | 1 | 0 | 1 | | 2016 | 7 | 0 | 7 | | 2017 | 4 | 0 | 4 | | 2018 | 4 | 0 | 4 | | 2019 | 6 | 0 | 6 | | 2020 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Hemangioma, Cavernous, Central Nervous System" by people in Profiles.
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Wei S, Li Y, Polster SP, Weber CR, Awad IA, Shen L. Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation. Int J Mol Sci. 2020 Jan 20; 21(2).
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Polster SP, Stadnik A, Akers AL, Cao Y, Christoforidis GA, Fam MD, Flemming KD, Girard R, Hobson N, Koenig JI, Koskimäki J, Lane K, Liao JK, Lee C, Lyne SB, McBee N, Morrison L, Piedad K, Shenkar R, Sorrentino M, Thompson RE, Whitehead KJ, Zeineddine HA, Hanley DF, Awad IA. Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial. Neurosurgery. 2019 12 01; 85(6):843-853.
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Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Roedel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML. Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Sci Transl Med. 2019 11 27; 11(520).
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Koskimäki J, Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Carrión-Penagos J, Lyne SB, Zeineddine HA, Shi C, Shenkar R, Romanos S, Avner K, Srinath A, Shen L, Detter MR, Snellings D, Cao Y, Lopez-Ramirez MA, Fonseca G, Tang AT, Faber P, Andrade J, Ginsberg M, Kahn ML, Marchuk DA, Girard R, Awad IA. Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Acta Neuropathol Commun. 2019 08 19; 7(1):132.
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Chapman EM, Lant B, Ohashi Y, Yu B, Schertzberg M, Go C, Dogra D, Koskimäki J, Girard R, Li Y, Fraser AG, Awad IA, Abdelilah-Seyfried S, Gingras AC, Derry WB. A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis. Nat Commun. 2019 04 17; 10(1):1791.
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Polster SP, Cao Y, Carroll T, Flemming K, Girard R, Hanley D, Hobson N, Kim H, Koenig J, Koskimäki J, Lane K, Majersik JJ, McBee N, Morrison L, Shenkar R, Stadnik A, Thompson RE, Zabramski J, Zeineddine HA, Awad IA. Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH). Neurosurgery. 2019 04 01; 84(4):954-964.
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Shenkar R, Peiper A, Pardo H, Moore T, Lightle R, Girard R, Hobson N, Polster SP, Koskimäki J, Zhang D, Lyne SB, Cao Y, Chaudagar K, Saadat L, Gallione C, Pytel P, Liao JK, Marchuk D, Awad IA. Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. Stroke. 2019 03; 50(3):738-744.
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Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood. 2019 01 17; 133(3):193-204.
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Wang Y, Li Y, Zou J, Polster SP, Lightle R, Moore T, Dimaano M, He TC, Weber CR, Awad IA, Shen L. The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation. FASEB J. 2019 02; 33(2):2132-2143.
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Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Koskimäki J, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IA. Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019 03; 99(3):319-330.
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