Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
|
| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
|
| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Actilyse- Actilyse
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
|
Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1998 | 2 | 0 | 2 |
| 1999 | 1 | 1 | 2 |
| 2001 | 2 | 0 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 2 | 3 |
| 2005 | 1 | 1 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 2 | 1 | 3 |
| 2009 | 4 | 1 | 5 |
| 2010 | 5 | 1 | 6 |
| 2011 | 5 | 3 | 8 |
| 2012 | 7 | 2 | 9 |
| 2013 | 8 | 2 | 10 |
| 2014 | 1 | 6 | 7 |
| 2015 | 6 | 5 | 11 |
| 2016 | 6 | 2 | 8 |
| 2017 | 2 | 2 | 4 |
| 2018 | 4 | 1 | 5 |
| 2019 | 5 | 1 | 6 |
| 2020 | 4 | 4 | 8 |
| 2021 | 3 | 3 | 6 |
| 2022 | 3 | 2 | 5 |
| 2023 | 2 | 3 | 5 |
| 2024 | 1 | 7 | 8 |
| 2025 | 1 | 2 | 3 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.
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Impact of Minimally Invasive Surgery on Midline Shift and Outcomes in Large Supratentorial Spontaneous Intracerebral Hemorrhage: Post Hoc Analysis of MISTIE III. Neurocrit Care. 2026 Feb; 44(1):261-272.
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Comparison of combined intravenous and intra-arterial thrombolysis with intravenous thrombolysis alone in stroke patients undergoing mechanical thrombectomy: a propensity-matched analysis. J Neurointerv Surg. 2025 Jun 01; 17(e2):e261-e268.
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Acute Ischemic Stroke in a Marathon Runner: Last Known Well at Mile 22 Case Report. Prehosp Emerg Care. 2025; 29(8):1148-1150.
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Intracerebral Hemorrhage: Keep It Simple. Stroke. 2024 12; 55(12):2942-2945.
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Intravenous Thrombolysis in Patients With Cervical Artery Dissection: A Secondary Analysis of the STOP-CAD Study. Neurology. 2024 Oct 08; 103(7):e209843.
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Does stereotactic thrombolysis with alteplase for intracerebral haemorrhage alter intraventricular haematoma volume? A secondary analysis of the MISTIE-III trial. J Neurol Neurosurg Psychiatry. 2024 Sep 17; 95(10):892-898.
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Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage. Stroke Vasc Neurol. 2024 08 27; 9(4):446-456.
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Pretreatment predictors of very poor clinical outcomes in medium vessel occlusion stroke patients treated with mechanical thrombectomy. Int J Stroke. 2024 Dec; 19(10):1123-1133.
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"Intraosseous administration of tenecteplase for thrombolysis of an acute ischemic stroke". J Stroke Cerebrovasc Dis. 2024 Sep; 33(9):107850.
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Symptomatic Hemorrhage Risks in Stroke Thrombolysis: aDAPTing to Real-World Practice. JAMA Neurol. 2024 Jul 01; 81(7):689-691.