Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
|
| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
|
| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Actilyse- Actilyse
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
|
Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 0 | 3 |
| 1996 | 1 | 1 | 2 |
| 1998 | 2 | 0 | 2 |
| 1999 | 1 | 1 | 2 |
| 2001 | 2 | 0 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 1 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 2 | 1 | 3 |
| 2009 | 4 | 1 | 5 |
| 2010 | 4 | 1 | 5 |
| 2011 | 5 | 3 | 8 |
| 2012 | 7 | 2 | 9 |
| 2013 | 8 | 2 | 10 |
| 2014 | 1 | 6 | 7 |
| 2015 | 6 | 4 | 10 |
| 2016 | 6 | 2 | 8 |
| 2017 | 2 | 3 | 5 |
| 2018 | 4 | 1 | 5 |
| 2019 | 4 | 1 | 5 |
| 2020 | 3 | 4 | 7 |
| 2021 | 3 | 3 | 6 |
| 2022 | 3 | 2 | 5 |
| 2023 | 1 | 3 | 4 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.
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Association Between Hematoma Volume and Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis. Stroke. 2024 Mar; 55(3):541-547.
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Challenges to Door-In-Door-Out Time Thresholds for Patients With Stroke-Reply. JAMA. 2023 12 19; 330(23):2306.
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Sensitivity and specificity of thromboelastography for hyperfibrinolysis: Comparison of TEG 5000 and TEG 6S CK LY30 systems. Am J Clin Pathol. 2023 11 02; 160(5):455-465.
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Minimally Invasive Surgery With Thrombolysis for Intracerebral Hemorrhage Evacuation: Bayesian Reanalysis of a Randomized Controlled Trial. Neurology. 2023 10 17; 101(16):e1614-e1622.
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Author Response: Endovascular vs Medical Management for Late Anterior Large Vessel Occlusion With Prestroke Disability: Analysis of CLEAR and RESCUE-Japan. Neurology. 2023 03 28; 100(13):642.
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One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe Disability. JAMA Neurol. 2022 09 01; 79(9):856-868.
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Effect of Thrombin and Incubation Time on Porcine Whole Blood Clot Elasticity and Recombinant Tissue Plasminogen Activator Susceptibility. Ultrasound Med Biol. 2022 08; 48(8):1567-1578.
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Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume. J Neuroimaging. 2022 09; 32(5):968-976.
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Race-Ethnic Disparities in Rates of Declination of Thrombolysis for Stroke. Neurology. 2022 04 19; 98(16):e1596-e1604.
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(More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy. PLoS One. 2022; 17(1):e0261567.