"Protein Kinase C-epsilon" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein kinase C subtype that was originally characterized as a CALCIUM-independent, serine-threonine kinase that is activated by PHORBOL ESTERS and DIACYLGLYCEROLS. It is targeted to specific cellular compartments in response to extracellular signals that activate G-PROTEIN-COUPLED RECEPTORS; TYROSINE KINASE RECEPTORS; and intracellular protein tyrosine kinase.
| Descriptor ID |
D051744
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.750
|
| Concept/Terms |
Protein Kinase C-epsilon- Protein Kinase C-epsilon
- Kinase C-epsilon, Protein
- PKC-epsilon Serine Threonine Kinase
- PKC epsilon Serine Threonine Kinase
- Protein Kinase C epsilon
- PKC epsilon
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-epsilon".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-epsilon".
This graph shows the total number of publications written about "Protein Kinase C-epsilon" by people in this website by year, and whether "Protein Kinase C-epsilon" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C-epsilon" by people in Profiles.
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PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages. Atherosclerosis. 2017 04; 259:51-59.
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PKCe mediates resistin-induced NADPH oxidase activation and inflammation leading to smooth muscle cell dysfunction and intimal hyperplasia. Atherosclerosis. 2016 10; 253:29-37.
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Catenin delta-1 (CTNND1) phosphorylation controls the mesenchymal to epithelial transition in astrocytic tumors. Hum Mol Genet. 2016 10 01; 25(19):4201-4210.
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Activated PKC{delta} and PKC{epsilon} inhibit epithelial chloride secretion response to cAMP via inducing internalization of the Na+-K+-2Cl- cotransporter NKCC1. J Biol Chem. 2010 Oct 29; 285(44):34072-85.
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Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner. J Biol Chem. 2009 Nov 13; 284(46):31834-42.
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Lysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrier disruption and lung injury. J Biol Chem. 2009 Sep 04; 284(36):24123-32.
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Hypothermia-induced cardioprotection using extended ischemia and early reperfusion cooling. Am J Physiol Heart Circ Physiol. 2007 Apr; 292(4):H1995-2003.
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Dynamic regulation of Na(+)-K(+)-2Cl(-) cotransporter surface expression by PKC-{epsilon} in Cl(-)--secretory epithelia. Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1332-42.
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Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68.
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Differential subcellular targeting of PKC-epsilon in response to pharmacological or ischemic stimuli in intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 2005 Jan; 288(1):G135-42.