"Protein Kinase C-theta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.
| Descriptor ID |
D000074121
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.075
|
| Concept/Terms |
Protein Kinase C-theta- Protein Kinase C-theta
- Protein Kinase C, theta
- PRKCQ
- Protein Kinase C theta
- PKC-theta
- PKC theta
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-theta".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-theta".
This graph shows the total number of publications written about "Protein Kinase C-theta" by people in this website by year, and whether "Protein Kinase C-theta" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 3 | 3 |
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Below are the most recent publications written about "Protein Kinase C-theta" by people in Profiles.
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PKC? regulates T cell motility via ezrin-radixin-moesin localization to the uropod. PLoS One. 2013; 8(11):e78940.
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Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet Genomics. 2013 Sep; 23(9):470-8.
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B cells assist allograft rejection in the deficiency of protein kinase c-theta. Transpl Int. 2013 Sep; 26(9):919-27.
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CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation. Mol Biol Cell. 2011 Apr; 22(7):954-63.
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Protein kinase Ctheta focusing at the cSMAC is a consequence rather than cause of TCR signaling and is dependent on the MEK/ERK pathway. J Immunol. 2009 May 15; 182(10):6022-30.
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Deficiency of protein kinase C-theta facilitates tolerance induction. Transplantation. 2009 Feb 27; 87(4):507-16.
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A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection. J Immunol. 2008 Jul 01; 181(1):513-20.
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T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol. 2008 Apr; 28(7):2470-80.
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CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9369-73.
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Different protein kinase C isoforms determine growth factor specificity in neuronal cells. Mol Cell Biol. 2000 Aug; 20(15):5392-403.