 Quinidine
"Quinidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
| Descriptor ID |
D011802
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| MeSH Number(s) |
D03.132.206.636 D03.438.810.699 D03.605.687.637
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| Concept/Terms |
Quinidex- Quinidex
- Robins Brand of Quinidine Sulfate
Apo-Quinidine- Apo-Quinidine
- Apo Quinidine
- Apotex Brand of Quinidine Sulfate
Quincardine- Quincardine
- Fawns & McAllan Brand of Quinidine Sulfate
Adaquin- Adaquin
- Nelson Brand of Quinidine Sulfate
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Below are MeSH descriptors whose meaning is more general than "Quinidine".
Below are MeSH descriptors whose meaning is more specific than "Quinidine".
This graph shows the total number of publications written about "Quinidine" by people in this website by year, and whether "Quinidine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 1 | 0 | 1 | | 1988 | 0 | 1 | 1 | | 1992 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 2 | 0 | 2 | | 2010 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Quinidine" by people in Profiles.
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Shaibani AI, Pope LE, Thisted R, Hepner A. Efficacy and safety of dextromethorphan/quinidine at two dosage levels for diabetic neuropathic pain: a double-blind, placebo-controlled, multicenter study. Pain Med. 2012 Feb; 13(2):243-54.
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Pioro EP, Brooks BR, Cummings J, Schiffer R, Thisted RA, Wynn D, Hepner A, Kaye R. Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect. Ann Neurol. 2010 Nov; 68(5):693-702.
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Thisted RA, Klaff L, Schwartz SL, Wymer JP, Culligan NW, Gerard G, Pope LE, Berg JE. Dextromethorphan and quinidine in adult patients with uncontrolled painful diabetic peripheral neuropathy: a 29-day, multicenter, open-label, dose-escalation study. Clin Ther. 2006 Oct; 28(10):1607-18.
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Panitch HS, Thisted RA, Smith RA, Wynn DR, Wymer JP, Achiron A, Vollmer TL, Mandler RN, Dietrich DW, Fletcher M, Pope LE, Berg JE, Miller A. Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis. Ann Neurol. 2006 May; 59(5):780-7.
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Brooks BR, Thisted RA, Appel SH, Bradley WG, Olney RK, Berg JE, Pope LE, Smith RA. Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial. Neurology. 2004 Oct 26; 63(8):1364-70.
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Saito M, Sato R, Muñoz NM, Herrnreiter A, Oyaizu M, Kasugai H, Narahashi T, Leff AR. Association of granular exocytosis with Ca(2+)-activated K+ channels in human eosinophils. Am J Physiol. 1997 Jul; 273(1 Pt 1):L16-21.
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Newman D, Herre JM, Chin M, Scheinman MM, Franz M, Katzung B. Effects of sympathetic stimulation on use dependence of lidocaine, mexiletine, and quinidine in an intact canine model. Can J Physiol Pharmacol. 1992 Feb; 70(2):219-24.
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Sheets MF, Hanck DA, Fozzard HA. Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells. Circ Res. 1988 Aug; 63(2):386-98.
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Wong RK, Kikendall JW, Dachman AH. Quinaglute-induced esophagitis mimicking an esophageal mass. Ann Intern Med. 1986 Jul; 105(1):62-3.
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Sung RJ, Castellanos A, Mallon SM, Bloom MG, Gelband H, Myerburg RJ. Mechanisms of spontaneous alternation between reciprocating tachycardia and atrial flutter-fibrillation in the Wolff-Parkinson-White syndrome. Circulation. 1977 Sep; 56(3):409-16.
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