"Dextromethorphan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
| Descriptor ID |
D003915
|
| MeSH Number(s) |
D03.132.577.249.200 D03.605.497.212 D03.633.400.686.212 D04.615.723.795.200
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dextromethorphan".
Below are MeSH descriptors whose meaning is more specific than "Dextromethorphan".
This graph shows the total number of publications written about "Dextromethorphan" by people in this website by year, and whether "Dextromethorphan" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dextromethorphan" by people in Profiles.
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Dextromethorphan/quinidine for the treatment of bulbar impairment in amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2023 08; 10(8):1296-1304.
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Efficacy and safety of dextromethorphan/quinidine at two dosage levels for diabetic neuropathic pain: a double-blind, placebo-controlled, multicenter study. Pain Med. 2012 Feb; 13(2):243-54.
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Intentional Coricidin product exposures among Illinois adolescents. Am J Drug Alcohol Abuse. 2011 Nov; 37(6):509-14.
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Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect. Ann Neurol. 2010 Nov; 68(5):693-702.
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Dextromethorphan and quinidine in adult patients with uncontrolled painful diabetic peripheral neuropathy: a 29-day, multicenter, open-label, dose-escalation study. Clin Ther. 2006 Oct; 28(10):1607-18.
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Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis. Ann Neurol. 2006 May; 59(5):780-7.
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Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial. Neurology. 2004 Oct 26; 63(8):1364-70.
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Chemical analysis of ecstasy pills. JAMA. 2000 Nov 01; 284(17):2190.
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MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate. Invest Ophthalmol Vis Sci. 1992 Nov; 33(12):3463-8.
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Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis. Clin Pharmacol Ther. 1989 Mar; 45(3):328-33.