 Receptors, Glucocorticoid
"Receptors, Glucocorticoid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
| Descriptor ID |
D011965
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| MeSH Number(s) |
D12.776.260.698.750.430 D12.776.826.750.430 D12.776.930.669.750.430
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| Concept/Terms |
Receptors, Glucocorticoid- Receptors, Glucocorticoid
- Glucocorticoid Receptors
- Glucocorticoid Receptor
- Receptor, Glucocorticoid
- Receptors, Glucocorticoids
- Glucocorticoids Receptors
Receptors, Corticoid Type II- Receptors, Corticoid Type II
- Corticoid Type II Receptors
- Corticoid II Receptor
- Receptor, Corticoid II
- Receptors, Corticoid II
- Corticoid II Receptors
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Below are MeSH descriptors whose meaning is more general than "Receptors, Glucocorticoid".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- DNA-Binding Proteins [D12.776.260]
- Receptors, Cytoplasmic and Nuclear [D12.776.260.698]
- Receptors, Steroid [D12.776.260.698.750]
- Receptors, Glucocorticoid [D12.776.260.698.750.430]
- Receptors, Cytoplasmic and Nuclear [D12.776.826]
- Receptors, Steroid [D12.776.826.750]
- Receptors, Glucocorticoid [D12.776.826.750.430]
- Transcription Factors [D12.776.930]
- Receptors, Cytoplasmic and Nuclear [D12.776.930.669]
- Receptors, Steroid [D12.776.930.669.750]
- Receptors, Glucocorticoid [D12.776.930.669.750.430]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Glucocorticoid".
This graph shows the total number of publications written about "Receptors, Glucocorticoid" by people in this website by year, and whether "Receptors, Glucocorticoid" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1984 | 0 | 1 | 1 | | 1985 | 1 | 0 | 1 | | 1988 | 1 | 0 | 1 | | 1992 | 0 | 1 | 1 | | 1993 | 1 | 0 | 1 | | 1996 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 2 | 1 | 3 | | 2002 | 2 | 1 | 3 | | 2003 | 1 | 1 | 2 | | 2004 | 2 | 0 | 2 | | 2006 | 2 | 2 | 4 | | 2007 | 1 | 0 | 1 | | 2008 | 2 | 3 | 5 | | 2009 | 2 | 3 | 5 | | 2010 | 1 | 0 | 1 | | 2011 | 3 | 2 | 5 | | 2012 | 3 | 0 | 3 | | 2013 | 3 | 0 | 3 | | 2014 | 3 | 1 | 4 | | 2015 | 4 | 1 | 5 | | 2016 | 2 | 0 | 2 | | 2017 | 4 | 1 | 5 | | 2018 | 1 | 1 | 2 | | 2019 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptors, Glucocorticoid" by people in Profiles.
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Tonsing-Carter E, Hernandez KM, Kim CR, Harkless RV, Oh A, Bowie KR, West-Szymanski DC, Betancourt-Ponce MA, Green BD, Lastra RR, Fleming GF, Chandarlapaty S, Conzen SD. Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association. Breast Cancer Res. 2019 07 24; 21(1):82.
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Snyder-Mackler N, Sanz J, Kohn JN, Voyles T, Pique-Regi R, Wilson ME, Barreiro LB, Tung J. Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1219-1228.
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West DC, Kocherginsky M, Tonsing-Carter EY, Dolcen DN, Hosfield DJ, Lastra RR, Sinnwell JP, Thompson KJ, Bowie KR, Harkless RV, Skor MN, Pierce CF, Styke SC, Kim CR, de Wet L, Greene GL, Boughey JC, Goetz MP, Kalari KR, Wang L, Fleming GF, Györffy B, Conzen SD. Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer. Clin Cancer Res. 2018 07 15; 24(14):3433-3446.
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Tangen IL, Veneris JT, Halle MK, Werner HM, Trovik J, Akslen LA, Salvesen HB, Conzen SD, Fleming GF, Krakstad C. Expression of glucocorticoid receptor is associated with aggressive primary endometrial cancer and increases from primary to metastatic lesions. Gynecol Oncol. 2017 12; 147(3):672-677.
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Quattrocelli M, Barefield DY, Warner JL, Vo AH, Hadhazy M, Earley JU, Demonbreun AR, McNally EM. Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy. J Clin Invest. 2017 Jun 01; 127(6):2418-2432.
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Conzen SD. Recent advances in understanding glucocorticoid receptor function in cancer. Clin Adv Hematol Oncol. 2017 May; 15(5):338-340.
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Veneris JT, Darcy KM, Mhawech-Fauceglia P, Tian C, Lengyel E, Lastra RR, Pejovic T, Conzen SD, Fleming GF. High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer. Gynecol Oncol. 2017 07; 146(1):153-160.
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Kach J, Long TM, Selman P, Tonsing-Carter EY, Bacalao MA, Lastra RR, de Wet L, Comiskey S, Gillard M, VanOpstall C, West DC, Chan WC, Griend DV, Conzen SD, Szmulewitz RZ. Selective Glucocorticoid Receptor Modulators (SGRMs) Delay Castrate-Resistant Prostate Cancer Growth. Mol Cancer Ther. 2017 08; 16(8):1680-1692.
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West DC, Pan D, Tonsing-Carter EY, Hernandez KM, Pierce CF, Styke SC, Bowie KR, Garcia TI, Kocherginsky M, Conzen SD. GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome. Mol Cancer Res. 2016 08; 14(8):707-19.
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Agyeman AS, Jun WJ, Proia DA, Kim CR, Skor MN, Kocherginsky M, Conzen SD. Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer. Horm Cancer. 2016 Apr; 7(2):114-26.
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