"Immediate-Early Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
| Descriptor ID |
D017874
|
| MeSH Number(s) |
D12.776.460 D12.776.964.925.968
|
| Concept/Terms |
Immediate-Early Proteins- Immediate-Early Proteins
- Immediate Early Proteins
- Proteins, Immediate-Early
- Proteins, Immediate Early
|
Below are MeSH descriptors whose meaning is more general than "Immediate-Early Proteins".
Below are MeSH descriptors whose meaning is more specific than "Immediate-Early Proteins".
This graph shows the total number of publications written about "Immediate-Early Proteins" by people in this website by year, and whether "Immediate-Early Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 3 | 0 | 3 |
| 1996 | 0 | 2 | 2 |
| 1997 | 2 | 2 | 4 |
| 1998 | 1 | 0 | 1 |
| 1999 | 2 | 1 | 3 |
| 2000 | 0 | 2 | 2 |
| 2001 | 7 | 2 | 9 |
| 2002 | 9 | 2 | 11 |
| 2003 | 5 | 4 | 9 |
| 2004 | 7 | 5 | 12 |
| 2005 | 5 | 2 | 7 |
| 2006 | 6 | 3 | 9 |
| 2007 | 2 | 2 | 4 |
| 2008 | 9 | 0 | 9 |
| 2009 | 4 | 2 | 6 |
| 2010 | 5 | 0 | 5 |
| 2011 | 2 | 1 | 3 |
| 2012 | 2 | 1 | 3 |
| 2013 | 2 | 3 | 5 |
| 2014 | 2 | 1 | 3 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immediate-Early Proteins" by people in Profiles.
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Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt. Microbiol Spectr. 2023 02 14; 11(1):e0314422.
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Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23. Proc Natl Acad Sci U S A. 2021 12 21; 118(51).
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Genomic characterization of diffuse large B-cell lymphoma transformation of nodular lymphocyte-predominant Hodgkin lymphoma. Leukemia. 2020 08; 34(8):2238-2242.
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miRNAs Targeting ICP4 and Delivered to Susceptible Cells in Exosomes Block HSV-1 Replication in a Dose-Dependent Manner. Mol Ther. 2018 04 04; 26(4):1032-1039.
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PML plays both inimical and beneficial roles in HSV-1 replication. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):E3022-8.
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Vocal matching and intensity of begging calls are associated with a forebrain song circuit in a generalist brood parasite. Dev Neurobiol. 2016 Jun; 76(6):615-25.
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Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer. Horm Cancer. 2014 Apr; 5(2):72-89.
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The stability of herpes simplex virus 1 ICP0 early after infection is defined by the RING finger and the UL13 protein kinase. J Virol. 2014 May; 88(10):5437-43.
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HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):E611-7.
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Serum- and glucocorticoid-induced protein kinase 1 (SGK1) is regulated by store-operated Ca2+ entry and mediates cytoprotection against necrotic cell death. J Biol Chem. 2013 Nov 08; 288(45):32708-32719.