"alpha-Mannosidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
| Descriptor ID |
D043323
|
| MeSH Number(s) |
D08.811.277.450.625.500
|
| Concept/Terms |
alpha-Mannosidase- alpha-Mannosidase
- alpha Mannosidase
- alpha-D-Mannoside Mannohydrolase
- Mannohydrolase, alpha-D-Mannoside
- alpha D Mannoside Mannohydrolase
- Neutral alpha-Mannosidase
- Neutral alpha Mannosidase
- alpha-Mannosidase, Neutral
- alpha-D-Mannosidase
- alpha D Mannosidase
Lysosomal alpha-Mannosidase- Lysosomal alpha-Mannosidase
- Lysosomal alpha Mannosidase
- alpha-Mannosidase, Lysosomal
- LAMAN
- alpha Mannosidase B
- Mannosidase B, alpha
|
Below are MeSH descriptors whose meaning is more general than "alpha-Mannosidase".
Below are MeSH descriptors whose meaning is more specific than "alpha-Mannosidase".
This graph shows the total number of publications written about "alpha-Mannosidase" by people in this website by year, and whether "alpha-Mannosidase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
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Below are the most recent publications written about "alpha-Mannosidase" by people in Profiles.
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Patient with bilateral periventricular nodular heterotopia and polymicrogyria with apparently balanced reciprocal translocation t(1;6)(p12;p12.2) that interrupts the mannosidase alpha, class 1A, and glutathione S-transferase A2 genes. J Med Genet. 2003 Dec; 40(12):e128.