 Connective Tissue Growth Factor
"Connective Tissue Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
| Descriptor ID |
D055513
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| MeSH Number(s) |
D12.644.276.200.100 D12.776.467.200.100 D12.776.860.300.200.100 D23.529.237.100
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| Concept/Terms |
Connective Tissue Growth Factor- Connective Tissue Growth Factor
- Hypertrophic Chondrocyte-Specific Protein 24
- Hypertrophic Chondrocyte Specific Protein 24
- IGF-Binding Protein-Related Protein-2
- IGF Binding Protein Related Protein 2
- IGFBP-rP2
- Insulin-Like Growth Factor Binding Protein 8
- Insulin Like Growth Factor Binding Protein 8
- CCN2 Protein
- IGFBP-8
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Below are MeSH descriptors whose meaning is more general than "Connective Tissue Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Connective Tissue Growth Factor".
This graph shows the total number of publications written about "Connective Tissue Growth Factor" by people in this website by year, and whether "Connective Tissue Growth Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Connective Tissue Growth Factor" by people in Profiles.
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Deb DK, Chen Y, Sun J, Wang Y, Li YC. ATP-citrate lyase is essential for high glucose-induced histone hyperacetylation and fibrogenic gene upregulation in mesangial cells. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F423-F429.
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Ren W, Sun X, Wang K, Feng H, Liu Y, Fei C, Wan S, Wang W, Luo J, Shi Q, Tang M, Zuo G, Weng Y, He T, Zhang Y. BMP9 inhibits the bone metastasis of breast cancer cells by downregulating CCN2 (connective tissue growth factor, CTGF) expression. Mol Biol Rep. 2014 Mar; 41(3):1373-83.
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Chen G, Chen X, Sukumar A, Gao B, Curley J, Schnaper HW, Ingram AJ, Krepinsky JC. TGFß receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells. J Cell Sci. 2013 Aug 15; 126(Pt 16):3697-712.
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Biernacka A, Dobaczewski M, Frangogiannis NG. TGF-ß signaling in fibrosis. Growth Factors. 2011 Oct; 29(5):196-202.
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Lee CH, Shah B, Moioli EK, Mao JJ. CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model. J Clin Invest. 2010 Sep; 120(9):3340-9.
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Zhang Y, Kong J, Deb DK, Chang A, Li YC. Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system. J Am Soc Nephrol. 2010 Jun; 21(6):966-73.
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Sisco M, Kryger ZB, O'Shaughnessy KD, Kim PS, Schultz GS, Ding XZ, Roy NK, Dean NM, Mustoe TA. Antisense inhibition of connective tissue growth factor (CTGF/CCN2) mRNA limits hypertrophic scarring without affecting wound healing in vivo. Wound Repair Regen. 2008 Sep-Oct; 16(5):661-73.
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Zhang Z, Sun L, Wang Y, Ning G, Minto AW, Kong J, Quigg RJ, Li YC. Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int. 2008 Jan; 73(2):163-71.
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Lee CH, Moioli EK, Mao JJ. Fibroblastic differentiation of human mesenchymal stem cells using connective tissue growth factor. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:775-8.
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Luo Q, Kang Q, Si W, Jiang W, Park JK, Peng Y, Li X, Luu HH, Luo J, Montag AG, Haydon RC, He TC. Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. J Biol Chem. 2004 Dec 31; 279(53):55958-68.
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