"Septins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of GTP-binding proteins that were initially identified in YEASTS where they were shown to initiate the process of septation and bud formation. Septins form into hetero-oligomeric complexes that are comprised of several distinct septin subunits. These complexes can act as cytoskeletal elements that play important roles in CYTOKINESIS, cytoskeletal reorganization, BIOLOGICAL TRANSPORT, and membrane dynamics.
| Descriptor ID |
D058112
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| MeSH Number(s) |
D08.811.277.040.330.300.700 D12.776.157.325.757 D12.776.220.932
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Septins".
Below are MeSH descriptors whose meaning is more specific than "Septins".
This graph shows the total number of publications written about "Septins" by people in this website by year, and whether "Septins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "Septins" by people in Profiles.
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Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nat Commun. 2023 07 25; 14(1):4101.
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Septins regulate border cell surface geometry, shape, and motility downstream of Rho in Drosophila. Dev Cell. 2023 08 07; 58(15):1399-1413.e5.
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Dissection of molecular assembly dynamics by tracking orientation and position of single molecules in live cells. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6352-E6361.
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Cytoskeletal dynamics: a view from the membrane. J Cell Biol. 2015 May 11; 209(3):329-37.
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Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Med. 2011 Dec 14; 9:133.
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Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity. J Cell Sci. 2010 Apr 01; 123(Pt 7):1099-107.
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Mammalian septins nomenclature. Mol Biol Cell. 2002 Dec; 13(12):4111-3.
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MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25). Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6428-33.