"Vinculin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytoskeletal protein associated with cell-cell and cell-matrix interactions. The amino acid sequence of human vinculin has been determined. The protein consists of 1066 amino acid residues and its gene has been assigned to chromosome 10.
| Descriptor ID |
D016596
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| MeSH Number(s) |
D12.776.220.990
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Vinculin".
Below are MeSH descriptors whose meaning is more specific than "Vinculin".
This graph shows the total number of publications written about "Vinculin" by people in this website by year, and whether "Vinculin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 1 | 1 | 2 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Vinculin" by people in Profiles.
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Dual role of vinculin in barrier-disruptive and barrier-enhancing endothelial cell responses. Cell Signal. 2016 Jun; 28(6):541-51.
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Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen. FASEB J. 2015 Nov; 29(11):4555-67.
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Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol. 2013 Jul 08; 202(1):163-77.
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Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions. Proc Natl Acad Sci U S A. 2010 Jul 27; 107(30):13324-9.
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Initiation of apoptosis by actin cytoskeletal derangement in human airway epithelial cells. Am J Respir Cell Mol Biol. 2001 Mar; 24(3):282-94.
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Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer. Biochem Biophys Res Commun. 2000 Oct 14; 277(1):93-9.
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The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase. J Biol Chem. 1997 Dec 26; 272(52):33373-6.
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Mechanical forces regulate focal adhesion and costamere assembly in cardiac myocytes. Am J Physiol. 1997 Aug; 273(2 Pt 2):H546-56.
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Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL. Oncogene. 1995 Sep 21; 11(6):1149-55.
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Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin. J Biol Chem. 1993 Apr 15; 268(11):8053-9.