Elongation Factor 2 Kinase
"Elongation Factor 2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A monomeric calcium-calmodulin-dependent protein kinase subtype that specifically phosphorylates PEPTIDE ELONGATION FACTOR 2. The enzyme lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE, however it is regulated by phosphorylation by PROTEIN KINASE A and through intramolecular autophosphorylation.
|Elongation Factor 2 Kinase
- Elongation Factor 2 Kinase
- Protein Kinase CPK3
- Kinase CPK3, Protein
- Calcium-Calmodulin-Dependent Protein Kinase Type 3
- Calcium Calmodulin Dependent Protein Kinase Type 3
- Eukaryotic Elongation Factor-2 Kinase
- Eukaryotic Elongation Factor 2 Kinase
- CAM Kinase III
- Cam PK III
- E-2 Kinase
- E 2 Kinase
- eEF-2-Specific Ca and Calmodulin-Dependent Protein Kinase III
- eEF 2 Specific Ca and Calmodulin Dependent Protein Kinase III
- Calmodulin-Dependent Protein Kinase III
- Calmodulin Dependent Protein Kinase III
- EF-2 Kinase
- EF 2 Kinase
- Kinase, EF-2
Below are MeSH descriptors whose meaning is more general than "Elongation Factor 2 Kinase".
Below are MeSH descriptors whose meaning is more specific than "Elongation Factor 2 Kinase".
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Below are the most recent publications written about "Elongation Factor 2 Kinase" by people in Profiles.
De Novo variants in EEF2 cause a neurodevelopmental disorder with benign external hydrocephalus. Hum Mol Genet. 2021 02 25; 29(24):3892-3899.
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell. 2013 May 23; 153(5):1064-79.
A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult. Hum Mol Genet. 2012 Dec 15; 21(26):5472-83.
Nerve growth factor-induced down-regulation of calmodulin-dependent protein kinase III in PC12 cells involves cyclic AMP-dependent protein kinase. J Neurochem. 1990 Mar; 54(3):1034-9.
Rapid activation of calmodulin-dependent protein kinase III in mitogen-stimulated human fibroblasts. Correlation with intracellular Ca2+ transients. J Biol Chem. 1987 Jul 15; 262(20):9785-92.