 Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
"Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NAD-dependent enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein]. It has a preference for acyl groups with a carbon chain length between 4 to 16.
| Descriptor ID |
D050753
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| MeSH Number(s) |
D08.811.682.660.387
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| Concept/Terms |
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)- Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
- NADH-Dependent Enoyl-ACP Reductase
- Enoyl-ACP Reductase, NADH-Dependent
- NADH Dependent Enoyl ACP Reductase
- Reductase, NADH-Dependent Enoyl-ACP
- NADH-Enoyl ACP Reductase
- ACP Reductase, NADH-Enoyl
- NADH Enoyl ACP Reductase
- Reductase, NADH-Enoyl ACP
- Enoyl(Acyl-Carrier-Protein) Reductase (NADH)
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Below are MeSH descriptors whose meaning is more general than "Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)".
Below are MeSH descriptors whose meaning is more specific than "Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)".
This graph shows the total number of publications written about "Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)" by people in this website by year, and whether "Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2013 | 5 | 0 | 5 |
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Below are the most recent publications written about "Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)" by people in Profiles.
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Wilkinson C, McPhillie MJ, Zhou Y, Woods S, Afanador GA, Rawson S, Khaliq F, Prigge ST, Roberts CW, Rice DW, McLeod R, Fishwick CW, Muench SP. The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target. Bioorg Med Chem Lett. 2014 Feb 01; 24(3):911-6.
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Afanador GA, Muench SP, McPhillie M, Fomovska A, Schön A, Zhou Y, Cheng G, Stec J, Freundlich JS, Shieh HM, Anderson JW, Jacobus DP, Fidock DA, Kozikowski AP, Fishwick CW, Rice DW, Freire E, McLeod R, Prigge ST. Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry. 2013 Dec 23; 52(51):9155-66.
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Stec J, Fomovska A, Afanador GA, Muench SP, Zhou Y, Lai BS, El Bissati K, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Sommervile C, Woods S, Roberts CW, Rice D, Prigge ST, McLeod R, Kozikowski AP. Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii. ChemMedChem. 2013 Jul; 8(7):1138-60.
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Muench SP, Stec J, Zhou Y, Afanador GA, McPhillie MJ, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Prigge ST, Rice DW, McLeod R. Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides. Bioorg Med Chem Lett. 2013 Jun 15; 23(12):3551-5.
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Cheng G, Muench SP, Zhou Y, Afanador GA, Mui EJ, Fomovska A, Lai BS, Prigge ST, Woods S, Roberts CW, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Rice DW, McLeod R. Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2035-43.
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Tipparaju SK, Muench SP, Mui EJ, Ruzheinikov SN, Lu JZ, Hutson SL, Kirisits MJ, Prigge ST, Roberts CW, Henriquez FL, Kozikowski AP, Rice DW, McLeod RL. Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. J Med Chem. 2010 Sep 09; 53(17):6287-300.
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Muench SP, Prigge ST, McLeod R, Rafferty JB, Kirisits MJ, Roberts CW, Mui EJ, Rice DW. Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents. Acta Crystallogr D Biol Crystallogr. 2007 Mar; 63(Pt 3):328-38.
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Muench SP, Prigge ST, Zhu L, Kirisits MJ, Roberts CW, Wernimont S, McLeod R, Rice DW. Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 01; 62(Pt 6):604-6.
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Samuel BU, Hearn B, Mack D, Wender P, Rothbard J, Kirisits MJ, Mui E, Wernimont S, Roberts CW, Muench SP, Rice DW, Prigge ST, Law AB, McLeod R. Delivery of antimicrobials into parasites. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14281-6.
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Gornicki P. Apicoplast fatty acid biosynthesis as a target for medical intervention in apicomplexan parasites. Int J Parasitol. 2003 Aug; 33(9):885-96.
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