Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
"Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NAD-dependent enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein]. It has a preference for acyl groups with a carbon chain length between 4 to 16.
| Descriptor ID |
D050753
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| MeSH Number(s) |
D08.811.682.660.387
|
| Concept/Terms |
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)- Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
- NADH-Dependent Enoyl-ACP Reductase
- Enoyl-ACP Reductase, NADH-Dependent
- NADH Dependent Enoyl ACP Reductase
- Reductase, NADH-Dependent Enoyl-ACP
- NADH-Enoyl ACP Reductase
- ACP Reductase, NADH-Enoyl
- NADH Enoyl ACP Reductase
- Reductase, NADH-Enoyl ACP
- Enoyl(Acyl-Carrier-Protein) Reductase (NADH)
|
Below are MeSH descriptors whose meaning is more general than "Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)".
Below are MeSH descriptors whose meaning is more specific than "Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)".
This graph shows the total number of publications written about "Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)" by people in this website by year, and whether "Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 5 | 0 | 5 |
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Below are the most recent publications written about "Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)" by people in Profiles.
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The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target. Bioorg Med Chem Lett. 2014 Feb 01; 24(3):911-6.
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Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry. 2013 Dec 23; 52(51):9155-66.
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Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii. ChemMedChem. 2013 Jul; 8(7):1138-60.
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Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides. Bioorg Med Chem Lett. 2013 Jun 15; 23(12):3551-5.
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Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2035-43.
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Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. J Med Chem. 2010 Sep 09; 53(17):6287-300.
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Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents. Acta Crystallogr D Biol Crystallogr. 2007 Mar; 63(Pt 3):328-38.
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Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 01; 62(Pt 6):604-6.
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Delivery of antimicrobials into parasites. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14281-6.
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Apicoplast fatty acid biosynthesis as a target for medical intervention in apicomplexan parasites. Int J Parasitol. 2003 Aug; 33(9):885-96.