3-Oxo-5-alpha-Steroid 4-Dehydrogenase
"3-Oxo-5-alpha-Steroid 4-Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the reduction of TESTOSTERONE to 5-ALPHA DIHYDROTESTOSTERONE.
| Descriptor ID |
D013741
|
| MeSH Number(s) |
D08.811.682.660.465
|
| Concept/Terms |
3-Oxo-5-alpha-Steroid 4-Dehydrogenase- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
- 3 Oxo 5 alpha Steroid 4 Dehydrogenase
- 3-oxo-5alpha-Steroid 4-Dehydrogenase (NADP+)
- Steroid delta-4-5-alpha Reductase
- Reductase, Steroid delta-4-5-alpha
- Steroid delta 4 5 alpha Reductase
- delta-4-5-alpha Reductase, Steroid
- Testosterone 5-alpha-Reductase
- Testosterone 5 alpha Reductase
- Testosterone delta-4-5-alpha-Reductase
- Testosterone delta 4 5 alpha Reductase
- delta-4-5-alpha-Reductase, Testosterone
- 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase
- 3 Keto 5 alpha Steroid delta 4 Dehydrogenase
- delta-4-Dehydrogenase, 3-Keto-5-alpha-Steroid
- 4-Ene-3-Oxosteroid-5alpha-Reductase
- 4 Ene 3 Oxosteroid 5alpha Reductase
- 4-Ene-5-alpha-Reductase
- 4 Ene 5 alpha Reductase
- 5-alpha-Reductase, Testosterone
- 5 alpha Reductase, Testosterone
- delta(4)-3-Ketosteroid-5alpha-Reductase
- NADH-5-alpha-Reductase
- NADH 5 alpha Reductase
- NADPH delta(4)-3-Ketosteroid 5 alpha-Oxidoreductase
- Steroid 5-alpha-Reductase
- 5-alpha-Reductase, Steroid
- Steroid 5 alpha Reductase
- Steroid 5Alpha Reductase
- 5Alpha Reductase, Steroid
- Reductase, Steroid 5Alpha
- 3-oxo-5 alpha-Steroid 4-Dehydrogenase (NADP+)
- delta 4-3-keto Steroid 5 alpha-Oxidoreductase
- delta 4 3 keto Steroid 5 alpha Oxidoreductase
- delta4-3-ketosteroid 5alpha-Oxidoreductase
- 5alpha-Oxidoreductase, delta4-3-ketosteroid
- delta4 3 ketosteroid 5alpha Oxidoreductase
|
Below are MeSH descriptors whose meaning is more general than "3-Oxo-5-alpha-Steroid 4-Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "3-Oxo-5-alpha-Steroid 4-Dehydrogenase".
This graph shows the total number of publications written about "3-Oxo-5-alpha-Steroid 4-Dehydrogenase" by people in this website by year, and whether "3-Oxo-5-alpha-Steroid 4-Dehydrogenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2007 | 2 | 0 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "3-Oxo-5-alpha-Steroid 4-Dehydrogenase" by people in Profiles.
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NF-?B and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance. Prostate. 2016 08; 76(11):1004-18.
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SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell. 2010 Jul 23; 142(2):203-17.
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5alphaDH-DOC (5alpha-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate cancer. Cancer Sci. 2010 Aug; 101(8):1897-904.
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Editorial comment on: Pharmacological approaches to reducing the risk of prostate cancer. Eur Urol. 2009 May; 55(5):1073-4.
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Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci. 2008 Jan; 99(1):81-6.
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SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness. Prostate. 2007 Nov 01; 67(15):1654-63.
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Preputial sebocyte 5alpha-reductase isoform specificity. Endocrinology. 1997 Oct; 138(10):4416-20.
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Studies of androgen metabolism and action in cultured hair and skin cells. J Steroid Biochem. 1986 May; 24(5):1053-60.
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Changes in the metabolism of dihydrotestosterone in the hyperplastic human prostate. J Clin Endocrinol Metab. 1983 Jan; 56(1):139-46.