 Germinal Center
"Germinal Center" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The activated center of a lymphoid follicle in secondary lymphoid tissue where B-LYMPHOCYTES are stimulated by antigens and helper T cells (T-LYMPHOCYTES, HELPER-INDUCER) are stimulated to generate memory cells.
| Descriptor ID |
D018858
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| MeSH Number(s) |
A10.549.250 A10.549.400.500 A15.382.520.604.250 A15.382.520.604.412.500
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| Concept/Terms |
Germinal Center- Germinal Center
- Center, Germinal
- Centers, Germinal
- Germinal Centers
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Below are MeSH descriptors whose meaning is more general than "Germinal Center".
Below are MeSH descriptors whose meaning is more specific than "Germinal Center".
This graph shows the total number of publications written about "Germinal Center" by people in this website by year, and whether "Germinal Center" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 2002 | 2 | 2 | 4 | | 2003 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 2 | 0 | 2 | | 2013 | 2 | 0 | 2 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 3 | 4 | | 2016 | 1 | 2 | 3 | | 2017 | 0 | 1 | 1 | | 2018 | 2 | 0 | 2 | | 2020 | 3 | 0 | 3 | | 2021 | 1 | 2 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Germinal Center" by people in Profiles.
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Cook SL, Sievert EP, Sciammas R. B Cell-Intrinsic IRF4 Haploinsufficiency Impairs Affinity Maturation. J Immunol. 2021 12 15; 207(12):2992-3003.
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Kennedy DE, Clark MR. Compartments and Connections Within the Germinal Center. Front Immunol. 2021; 12:659151.
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Wagar LE, Salahudeen A, Constantz CM, Wendel BS, Lyons MM, Mallajosyula V, Jatt LP, Adamska JZ, Blum LK, Gupta N, Jackson KJL, Yang F, Röltgen K, Roskin KM, Blaine KM, Meister KD, Ahmad IN, Cortese M, Dora EG, Tucker SN, Sperling AI, Jain A, Davies DH, Felgner PL, Hammer GB, Kim PS, Robinson WH, Boyd SD, Kuo CJ, Davis MM. Modeling human adaptive immune responses with tonsil organoids. Nat Med. 2021 01; 27(1):125-135.
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Ricker E, Chinenov Y, Pannellini T, Flores-Castro D, Ye C, Gupta S, Manni M, Liao JK, Pernis AB. Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis. J Clin Invest. 2020 07 01; 130(7):3654-3670.
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Khiew SH, Jain D, Chen J, Yang J, Yin D, Young JS, Dent A, Sciammas R, Alegre ML, Chong AS. Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells. J Clin Invest. 2020 07 01; 130(7):3453-3466.
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Kennedy DE, Okoreeh MK, Maienschein-Cline M, Ai J, Veselits M, McLean KC, Dhungana Y, Wang H, Peng J, Chi H, Mandal M, Clark MR. Novel specialized cell state and spatial compartments within the germinal center. Nat Immunol. 2020 06; 21(6):660-670.
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Guthmiller JJ, Wilson PC. It's Hard to Teach an Old B Cell New Tricks. Cell. 2020 01 09; 180(1):18-20.
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Chong AS. New insights into the development of B cell responses: Implications for solid organ transplantation. Hum Immunol. 2019 Jun; 80(6):378-384.
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Cho S, Lee HM, Yu IS, Choi YS, Huang HY, Hashemifar SS, Lin LL, Chen MC, Afanasiev ND, Khan AA, Lin SW, Rudensky AY, Crotty S, Lu LF. Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat Commun. 2018 07 16; 9(1):2757.
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Rincon-Restrepo M, Mayer A, Hauert S, Bonner DK, Phelps EA, Hubbell JA, Swartz MA, Hirosue S. Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses. Biomaterials. 2017 07; 132:48-58.
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