"Germinal Center" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The activated center of a lymphoid follicle in secondary lymphoid tissue where B-LYMPHOCYTES are stimulated by antigens and helper T cells (T-LYMPHOCYTES, HELPER-INDUCER) are stimulated to generate memory cells.
| Descriptor ID |
D018858
|
| MeSH Number(s) |
A10.549.400.500 A15.382.520.604.412.500
|
| Concept/Terms |
Germinal Center- Germinal Center
- Center, Germinal
- Centers, Germinal
- Germinal Centers
|
Below are MeSH descriptors whose meaning is more general than "Germinal Center".
Below are MeSH descriptors whose meaning is more specific than "Germinal Center".
This graph shows the total number of publications written about "Germinal Center" by people in this website by year, and whether "Germinal Center" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2002 | 2 | 2 | 4 |
| 2003 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 2 | 0 | 2 |
| 2013 | 2 | 0 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 4 | 5 |
| 2016 | 1 | 3 | 4 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 3 | 0 | 3 |
| 2021 | 1 | 2 | 3 |
| 2023 | 1 | 2 | 3 |
| 2024 | 1 | 0 | 1 |
| 2025 | 0 | 2 | 2 |
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Below are the most recent publications written about "Germinal Center" by people in Profiles.
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Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis. Cell Host Microbe. 2025 Apr 09; 33(4):498-511.e10.
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Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells. Nat Commun. 2025 Mar 04; 16(1):2151.
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Plasma Cell Differentiation, Antibody Quality, and Initial Germinal Center B Cell Population Depend on Glucose Influx Rate. J Immunol. 2024 01 01; 212(1):43-56.
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Molecular mechanisms insulating proliferation from genotoxic stress in B lymphocytes. Trends Immunol. 2023 09; 44(9):668-677.
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STAT3 signaling in B cells controls germinal center zone organization and recycling. Cell Rep. 2023 05 30; 42(5):112512.
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Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control. Nat Immunol. 2023 05; 24(5):855-868.
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B Cell-Intrinsic IRF4 Haploinsufficiency Impairs Affinity Maturation. J Immunol. 2021 12 15; 207(12):2992-3003.
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Compartments and Connections Within the Germinal Center. Front Immunol. 2021; 12:659151.
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Modeling human adaptive immune responses with tonsil organoids. Nat Med. 2021 01; 27(1):125-135.
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Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis. J Clin Invest. 2020 07 01; 130(7):3654-3670.