"Sirtuin 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sirtuin family member found primarily in the CYTOPLASM. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.
| Descriptor ID |
D056565
|
| MeSH Number(s) |
D08.811.277.087.520.200.650.200 D08.811.913.400.725.115.961.200 D12.776.476.900.200
|
| Concept/Terms |
Sirtuin 2- Sirtuin 2
- Silent Mating Type Information Regulation 2 Homolog 2
|
Below are MeSH descriptors whose meaning is more general than "Sirtuin 2".
Below are MeSH descriptors whose meaning is more specific than "Sirtuin 2".
This graph shows the total number of publications written about "Sirtuin 2" by people in this website by year, and whether "Sirtuin 2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 4 | 0 | 4 |
| 2017 | 2 | 0 | 2 |
| 2018 | 5 | 0 | 5 |
| 2019 | 4 | 0 | 4 |
| 2020 | 2 | 0 | 2 |
| 2021 | 3 | 0 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sirtuin 2" by people in Profiles.
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SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress. Elife. 2025 May 07; 13.
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Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis. Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18):e2319833121.
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5-((3-Amidobenzyl)oxy)nicotinamides as SIRT2 Inhibitors: A Study of Constrained Analogs. Molecules. 2023 Nov 18; 28(22).
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Golgi stress induces SIRT2 to counteract Shigella infection via defatty-acylation. Nat Commun. 2022 08 02; 13(1):4494.
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Emerging roles of Sirtuin 2 in cardiovascular diseases. FASEB J. 2021 10; 35(10):e21841.
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High-Throughput Screening Identifies Ascorbyl Palmitate as a SIRT2 Deacetylase and Defatty-Acylase Inhibitor. ChemMedChem. 2021 11 19; 16(22):3484-3494.
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Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1-3 Inhibitors. ACS Chem Biol. 2021 07 16; 16(7):1266-1275.
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Substrate-Dependent Modulation of SIRT2 by a Fluorescent Probe, 1-Aminoanthracene. Biochemistry. 2020 10 13; 59(40):3869-3878.
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NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun. 2020 02 26; 11(1):1067.
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SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration. ACS Chem Biol. 2019 09 20; 14(9):2014-2023.