 Receptor, Serotonin, 5-HT1B
"Receptor, Serotonin, 5-HT1B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serotonin receptor subtype found at high levels in the BASAL GANGLIA and the frontal cortex. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D RECEPTOR. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigraine effect.
| Descriptor ID |
D044302
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| MeSH Number(s) |
D12.776.543.750.070.800.100.150 D12.776.543.750.100.800.100.150 D12.776.543.750.720.300.800.100.150 D12.776.543.750.720.670.100.500
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| Concept/Terms |
Receptor, Serotonin, 5-HT1B- Receptor, Serotonin, 5-HT1B
- 5-HT(1Dbeta) Receptor
- 5-HT1B Receptor
- 5 HT1B Receptor
- Receptor, 5-HT1B
- 5-HT1Dbeta Receptor
- 5 HT1Dbeta Receptor
- Receptor, 5-HT1Dbeta
- 5-Hydroxytryptamine 1B Receptor
- 1B Receptor, 5-Hydroxytryptamine
- 5 Hydroxytryptamine 1B Receptor
- Serotonin 1Dbeta Receptors
- 1Dbeta Receptors, Serotonin
- Receptors, Serotonin 1Dbeta
- Receptor, 5-Hydroxytryptamine 1B
- Receptor, 5 Hydroxytryptamine 1B
- Receptor, Serotonin Type 1Dbeta
- Serotonin 1B Receptor
- 1B Receptor, Serotonin
- Receptor, Serotonin 1B
- Serotonin 1D Beta Receptor
- Serotonin 1Dbeta Receptor
- 1Dbeta Receptor, Serotonin
- Receptor, Serotonin 1Dbeta
- 5-HT(1B) Receptor
- 5-Hydroxytryptamine 1B Receptors
- 1B Receptors, 5-Hydroxytryptamine
- 5 Hydroxytryptamine 1B Receptors
- Receptors, 5-Hydroxytryptamine 1B
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Below are MeSH descriptors whose meaning is more general than "Receptor, Serotonin, 5-HT1B".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Biogenic Amine [D12.776.543.750.070]
- Receptors, Serotonin [D12.776.543.750.070.800]
- Receptors, Serotonin, 5-HT1 [D12.776.543.750.070.800.100]
- Receptor, Serotonin, 5-HT1B [D12.776.543.750.070.800.100.150]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Serotonin [D12.776.543.750.100.800]
- Receptors, Serotonin, 5-HT1 [D12.776.543.750.100.800.100]
- Receptor, Serotonin, 5-HT1B [D12.776.543.750.100.800.100.150]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Biogenic Amine [D12.776.543.750.720.300]
- Receptors, Serotonin [D12.776.543.750.720.300.800]
- Receptors, Serotonin, 5-HT1 [D12.776.543.750.720.300.800.100]
- Receptor, Serotonin, 5-HT1B [D12.776.543.750.720.300.800.100.150]
- Receptors, Presynaptic [D12.776.543.750.720.670]
- Autoreceptors [D12.776.543.750.720.670.100]
- Receptor, Serotonin, 5-HT1B [D12.776.543.750.720.670.100.500]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Serotonin, 5-HT1B".
This graph shows the total number of publications written about "Receptor, Serotonin, 5-HT1B" by people in this website by year, and whether "Receptor, Serotonin, 5-HT1B" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptor, Serotonin, 5-HT1B" by people in Profiles.
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Bidwell LC, Gray JC, Weafer J, Palmer AA, de Wit H, MacKillop J. Genetic influences on ADHD symptom dimensions: Examination of a priori candidates, gene-based tests, genome-wide variation, and SNP heritability. Am J Med Genet B Neuropsychiatr Genet. 2017 Jun; 174(4):458-466.
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Woehrle NS, Klenotich SJ, Jamnia N, Ho EV, Dulawa SC. Effects of chronic fluoxetine treatment on serotonin 1B receptor-induced deficits in delayed alternation. Psychopharmacology (Berl). 2013 Jun; 227(3):545-51.
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Shanahan NA, Velez LP, Masten VL, Dulawa SC. Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice. Biol Psychiatry. 2011 Dec 01; 70(11):1039-48.
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Mathur BN, Capik NA, Alvarez VA, Lovinger DM. Serotonin induces long-term depression at corticostriatal synapses. J Neurosci. 2011 May 18; 31(20):7402-11.
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Shanahan NA, Holick Pierz KA, Masten VL, Waeber C, Ansorge M, Gingrich JA, Geyer MA, Hen R, Dulawa SC. Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice. Biol Psychiatry. 2009 Mar 01; 65(5):401-8.
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Dickel DE, Veenstra-VanderWeele J, Bivens NC, Wu X, Fischer DJ, Van Etten-Lee M, Himle JA, Leventhal BL, Cook EH, Hanna GL. Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder. Biol Psychiatry. 2007 Feb 01; 61(3):322-9.
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Duan J, Sanders AR, Molen JE, Martinolich L, Mowry BJ, Levinson DF, Crowe RR, Silverman JM, Gejman PV. Polymorphisms in the 5'-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression. Mol Psychiatry. 2003 Nov; 8(11):901-10.
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Sanders AR, Duan J, Gejman PV. DNA variation and psychopharmacology of the human serotonin receptor 1B (HTR1B) gene. Pharmacogenomics. 2002 Nov; 3(6):745-62.
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Sanders AR, Cao Q, Taylor J, Levin TE, Badner JA, Cravchik A, Comeron JM, Naruya S, Del Rosario A, Salvi DA, Walczyk KA, Mowry BJ, Levinson DF, Crowe RR, Silverman JM, Gejman PV. Genetic diversity of the human serotonin receptor 1B (HTR1B) gene. Genomics. 2001 Feb 15; 72(1):1-14.
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Dulawa SC, Gross C, Stark KL, Hen R, Geyer MA. Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition. Neuropsychopharmacology. 2000 Jun; 22(6):650-9.
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