 MAP Kinase Kinase Kinase 5
"MAP Kinase Kinase Kinase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 150-kDa MAP kinase kinase kinase that may play a role in the induction of APOPTOSIS. It has specificity for MAP KINASE KINASE 3; MAP KINASE KINASE 4; and MAP KINASE KINASE 6.
| Descriptor ID |
D048848
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| MeSH Number(s) |
D08.811.913.696.620.682.700.559.500 D12.644.360.400.500 D12.776.476.400.500
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| Concept/Terms |
MAP Kinase Kinase Kinase 5- MAP Kinase Kinase Kinase 5
- ASK1 Protein Kinase
- Protein Kinase, ASK1
- Mitogen-Activated Kinase Kinase Kinase Kinase 5
- Mitogen Activated Kinase Kinase Kinase Kinase 5
- MAPK Kinase Kinase 5
- MAPKKK5
- Apoptosis Signal-Regulating Kinase 1
- Apoptosis Signal Regulating Kinase 1
- MAP3K5 Protein Kinase
- Protein Kinase, MAP3K5
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Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinase 5".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinase 5".
This graph shows the total number of publications written about "MAP Kinase Kinase Kinase 5" by people in this website by year, and whether "MAP Kinase Kinase Kinase 5" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "MAP Kinase Kinase Kinase 5" by people in Profiles.
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Younossi ZM, Stepanova M, Lawitz E, Charlton M, Loomba R, Myers RP, Subramanian M, McHutchison JG, Goodman Z. Improvement of hepatic fibrosis and patient-reported outcomes in non-alcoholic steatohepatitis treated with selonsertib. Liver Int. 2018 10; 38(10):1849-1859.
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Loomba R, Lawitz E, Mantry PS, Jayakumar S, Caldwell SH, Arnold H, Diehl AM, Djedjos CS, Han L, Myers RP, Subramanian GM, McHutchison JG, Goodman ZD, Afdhal NH, Charlton MR. The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial. Hepatology. 2018 02; 67(2):549-559.
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Jin L, Li D, Lee JS, Elf S, Alesi GN, Fan J, Kang HB, Wang D, Fu H, Taunton J, Boggon TJ, Tucker M, Gu TL, Chen ZG, Shin DM, Khuri FR, Kang S. p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Mol Cell Biol. 2013 Jul; 33(13):2574-85.
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Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR. Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. J Biol Chem. 2009 Jan 23; 284(4):2176-86.
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Satoh M, Matter CM, Ogita H, Takeshita K, Wang CY, Dorn GW, Liao JK. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Circulation. 2007 Jun 26; 115(25):3197-204.
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Chiang E, Dang O, Anderson K, Matsuzawa A, Ichijo H, David M. Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J Immunol. 2006 May 15; 176(10):5720-4.
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Satoh M, Ogita H, Takeshita K, Mukai Y, Kwiatkowski DJ, Liao JK. Requirement of Rac1 in the development of cardiac hypertrophy. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7432-7.
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