"raf Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of closely-related serine-threonine kinases that were originally identified as the cellular homologs of the retrovirus-derived V-RAF KINASES. They are MAP kinase kinase kinases that play important roles in SIGNAL TRANSDUCTION.
| Descriptor ID |
D048490
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.559.842 D12.644.360.400.842 D12.776.476.400.842 D12.776.624.664.700.204
|
| Concept/Terms |
raf Kinases- raf Kinases
- Kinases, raf
- raf Proto-Oncogene Proteins
- Proto-Oncogene Proteins, raf
- raf Proto Oncogene Proteins
- raf MAP Kinase Kinase Kinases
- raf Serine-Theonine Protein Kinases
- raf Serine Theonine Protein Kinases
- Proto-Oncogene Proteins raf
- Proteins raf, Proto-Oncogene
- Proto Oncogene Proteins raf
mil-raf Protein Kinases- mil-raf Protein Kinases
- Kinases, mil-raf Protein
- Protein Kinases, mil-raf
- mil raf Protein Kinases
- MIL-RAF Proteins
- MIL RAF Proteins
|
Below are MeSH descriptors whose meaning is more general than "raf Kinases".
Below are MeSH descriptors whose meaning is more specific than "raf Kinases".
This graph shows the total number of publications written about "raf Kinases" by people in this website by year, and whether "raf Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "raf Kinases" by people in Profiles.
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Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. J Natl Cancer Inst. 2017 11 01; 109(11).
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Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. PLoS One. 2010 May 05; 5(5):e10479.
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Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop. Mol Cell Biol. 2009 Jun; 29(11):3076-87.
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Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism. Mol Cell Biol. 2009 Mar; 29(5):1306-20.
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Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target. Expert Opin Ther Targets. 2008 Oct; 12(10):1275-87.
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Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB. Gastroenterology. 2008 Aug; 135(2):539-51.
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Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor. Cell Res. 2008 Apr; 18(4):452-7.
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Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk. Crit Rev Biochem Mol Biol. 2006 Nov-Dec; 41(6):339-85.
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Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Mol Cell. 2006 Aug; 23(4):561-74.
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Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein. Cell Res. 2005 Jan; 15(1):19-23.