 Apolipoprotein E2
"Apolipoprotein E2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D053329
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| MeSH Number(s) |
D10.532.091.500.249 D12.776.070.400.500.249 D12.776.521.120.500.249
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| Concept/Terms |
Apolipoprotein E2- Apolipoprotein E2
- APOE-epsilon2
- APOE epsilon2
- ApoE2
- APOE-epsilon 2
- APOE epsilon 2
- Apo E-2
- Apo E 2
- Apo E2
- Apolipoprotein E-epsilon2
- Apolipoprotein E epsilon2
- Apolipoprotein E-2
- Apolipoprotein E 2
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Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E2".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E2".
This graph shows the total number of publications written about "Apolipoprotein E2" by people in this website by year, and whether "Apolipoprotein E2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2011 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apolipoprotein E2" by people in Profiles.
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Gaynor JW, Kim DS, Arrington CB, Atz AM, Bellinger DC, Burt AA, Ghanayem NS, Jacobs JP, Lee TM, Lewis AB, Mahle WT, Marino BS, Miller SG, Newburger JW, Pizarro C, Ravishankar C, Santani AB, Wilder NS, Jarvik GP, Mital S, Russell MW. Validation of association of the apolipoprotein E e2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants. J Thorac Cardiovasc Surg. 2014 Dec; 148(6):2560-6.
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Huang ZH, Maeda N, Mazzone T. Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis. J Lipid Res. 2011 Sep; 52(9):1733-41.
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Lucic D, Huang ZH, Gu de S, Altenburg MK, Maeda N, Mazzone T. Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor. J Lipid Res. 2007 Feb; 48(2):366-72.
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Sinnott BP, Mazzone T. Tuberous xanthomas associated with olanzapine therapy and hypertriglyceridemia in the setting of a rare apolipoprotein E mutation. Endocr Pract. 2006 Mar-Apr; 12(2):183-7.
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LaDu MJ, Lukens JR, Reardon CA, Getz GS. Association of human, rat, and rabbit apolipoprotein E with beta-amyloid. J Neurosci Res. 1997 Jul 01; 49(1):9-18.
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Xu PT, Schmechel D, Rothrock-Christian T, Burkhart DS, Qiu HL, Popko B, Sullivan P, Maeda N, Saunders AM, Roses AD, Gilbert JR. Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiol Dis. 1996; 3(3):229-45.
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