"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D001057
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| MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 4 | 1 | 5 |
| 1997 | 4 | 1 | 5 |
| 1998 | 3 | 2 | 5 |
| 1999 | 2 | 1 | 3 |
| 2000 | 4 | 2 | 6 |
| 2001 | 2 | 2 | 4 |
| 2002 | 2 | 1 | 3 |
| 2003 | 2 | 1 | 3 |
| 2004 | 2 | 2 | 4 |
| 2005 | 1 | 2 | 3 |
| 2006 | 2 | 0 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 2 | 3 |
| 2009 | 1 | 1 | 2 |
| 2010 | 3 | 1 | 4 |
| 2011 | 1 | 1 | 2 |
| 2012 | 3 | 1 | 4 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 4 | 5 |
| 2015 | 2 | 2 | 4 |
| 2016 | 3 | 1 | 4 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 5 | 6 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 2 | 2 | 4 |
| 2023 | 1 | 4 | 5 |
| 2024 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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SuperAging is not the inverse of common-variant Alzheimer's risk: evidence across genetic ancestries. Alzheimers Res Ther. 2026 Jul 23; 18(1).
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A prometabolite strategy inhibits cardiometabolic disease in an ApoE-/- murine model of atherosclerosis. JCI Insight. 2025 08 08; 10(15).
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The Amyloid Cascade Hypothesis: A Conclusion in Search of Support. Am J Pathol. 2025 11; 195(11):1988-1997.
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Association of APOE e4 Status With Long-term Declines in Odor Sensitivity, Odor Identification, and Cognition in Older US Adults. Neurology. 2023 09 26; 101(13):e1341-e1350.
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Profiling baseline performance on the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort near the midpoint of data collection. Alzheimers Dement. 2023 11; 19 Suppl 9:S8-S18.
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Interaction analysis of ancestry-enriched variants with APOE-?4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging. Sci Rep. 2023 03 29; 13(1):5114.
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ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science. 2023 01 13; 379(6628):eadd1236.
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Refining Risk for Alzheimer's Disease Among Heterozygous APOE?4 Carriers. J Alzheimers Dis. 2023; 94(2):483-489.
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Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease. Nat Commun. 2022 10 13; 13(1):6036.
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A metabolomic signature of the APOE2 allele. Geroscience. 2023 02; 45(1):415-426.