 Drug Discovery
"Drug Discovery" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process of finding chemicals for potential therapeutic use.
| Descriptor ID |
D055808
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| MeSH Number(s) |
E05.295 H01.158.703.007.675 H01.181.466.675
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Drug Discovery".
Below are MeSH descriptors whose meaning is more specific than "Drug Discovery".
This graph shows the total number of publications written about "Drug Discovery" by people in this website by year, and whether "Drug Discovery" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 2 | 3 | | 2009 | 2 | 4 | 6 | | 2010 | 4 | 2 | 6 | | 2011 | 5 | 2 | 7 | | 2012 | 5 | 0 | 5 | | 2013 | 3 | 2 | 5 | | 2014 | 3 | 3 | 6 | | 2015 | 3 | 12 | 15 | | 2016 | 6 | 1 | 7 | | 2017 | 3 | 3 | 6 | | 2018 | 3 | 3 | 6 | | 2019 | 2 | 2 | 4 | | 2020 | 2 | 0 | 2 | | 2021 | 2 | 2 | 4 |
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Below are the most recent publications written about "Drug Discovery" by people in Profiles.
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Yenerall P, Kollipara RK, Avila K, Peyton M, Eide CA, Bottomly D, McWeeney SK, Liu Y, Westover KD, Druker BJ, Minna JD, Kittler R. Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations. Cancer Res. 2021 09 15; 81(18):4685-4695.
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Yoshimaru T, Nakamura Y, Katagiri T. Functional genomics for breast cancer drug target discovery. J Hum Genet. 2021 Sep; 66(9):927-935.
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Morris A, McCorkindale W, Consortium TCM, Drayman N, Chodera JD, Tay S, London N, Lee AA. Discovery of SARS-CoV-2 main protease inhibitors using a synthesis-directed de novo design model. Chem Commun (Camb). 2021 Jun 15; 57(48):5909-5912.
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Butterfield NC, Curry KF, Steinberg J, Dewhurst H, Komla-Ebri D, Mannan NS, Adoum AT, Leitch VD, Logan JG, Waung JA, Ghirardello E, Southam L, Youlten SE, Wilkinson JM, McAninch EA, Vancollie VE, Kussy F, White JK, Lelliott CJ, Adams DJ, Jacques R, Bianco AC, Boyde A, Zeggini E, Croucher PI, Williams GR, Bassett JHD. Accelerating functional gene discovery in osteoarthritis. Nat Commun. 2021 01 20; 12(1):467.
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Dajnowicz S, Ghoreishi D, Modugula K, Damm W, Harder ED, Abel R, Wang L, Yu HS. Advancing Free-Energy Calculations of Metalloenzymes in Drug Discovery via Implementation of LFMM Potentials. J Chem Theory Comput. 2020 Nov 10; 16(11):6926-6937.
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Speltz TE, Moellering RE. Protein targeting with SAF(er) electrophiles. Nat Chem. 2020 10; 12(10):885-887.
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van der Velden DL, Hoes LR, van der Wijngaart H, van Berge Henegouwen JM, van Werkhoven E, Roepman P, Schilsky RL, de Leng WWJ, Huitema ADR, Nuijen B, Nederlof PM, van Herpen CML, de Groot DJA, Devriese LA, Hoeben A, de Jonge MJA, Chalabi M, Smit EF, de Langen AJ, Mehra N, Labots M, Kapiteijn E, Sleijfer S, Cuppen E, Verheul HMW, Gelderblom H, Voest EE. The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs. Nature. 2019 10; 574(7776):127-131.
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Yu HS, Gao C, Lupyan D, Wu Y, Kimura T, Wu C, Jacobson L, Harder E, Abel R, Wang L. Toward Atomistic Modeling of Irreversible Covalent Inhibitor Binding Kinetics. J Chem Inf Model. 2019 09 23; 59(9):3955-3967.
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Poser SW, Otto O, Arps-Forker C, Ge Y, Herbig M, Andree C, Gruetzmann K, Adasme MF, Stodolak S, Nikolakopoulou P, Park DM, Mcintyre A, Lesche M, Dahl A, Lennig P, Bornstein SR, Schroeck E, Klink B, Leker RR, Bickle M, Chrousos GP, Schroeder M, Cannistraci CV, Guck J, Androutsellis-Theotokis A. Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery. FASEB J. 2019 08; 33(8):9235-9249.
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Ding R, Zhang T, Wilson DJ, Xie J, Williams J, Xu Y, Ye Y, Chen L. Discovery of Irreversible p97 Inhibitors. J Med Chem. 2019 03 14; 62(5):2814-2829.
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