Copper-transporting ATPases
"Copper-transporting ATPases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.
| Descriptor ID |
D000073840
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| MeSH Number(s) |
D08.811.277.040.025.314.500 D12.776.157.530.450.250.656 D12.776.157.530.813.500 D12.776.543.585.450.250.656 D12.776.543.585.813.500
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| Concept/Terms |
Copper-transporting ATPases- Copper-transporting ATPases
- ATPases, Copper-transporting
- Copper transporting ATPases
- Cu(+)-transporting ATPases
- Copper-transporting Adenosine Triphosphatases
- Adenosine Triphosphatases, Copper-transporting
- Copper transporting Adenosine Triphosphatases
- Triphosphatases, Copper-transporting Adenosine
- Copper-transporting ATPase
- ATPase, Copper-transporting
- Copper transporting ATPase
- Cu-transporting ATPases
- ATPases, Cu-transporting
- Cu transporting ATPases
Wilson Disease Protein- Wilson Disease Protein
- ATP7B Cu-binding P type ATPase
- ATP7B Cu binding P type ATPase
- Copper-transporting ATPase 2
- Copper transporting ATPase 2
- ATPase, Cu++ transporting, beta Polypeptide (Wilson Disease)
- Wilson Disease Cu-binding P Type ATPase
- Wilson Disease Cu binding P Type ATPase
Copper-transporting ATPase 1- Copper-transporting ATPase 1
- ATPase 1, Copper-transporting
- Copper transporting ATPase 1
- Copper Pump 1
- Menkes Disease-associated Protein
- Menkes Disease associated Protein
- ATP7A Protein
- ATPase Copper Transporting alpha
Pineal Night-specific ATPase- Pineal Night-specific ATPase
- ATPase, Pineal Night-specific
- Night-specific ATPase, Pineal
- Pineal Night specific ATPase
- PINA Enzyme
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Below are MeSH descriptors whose meaning is more general than "Copper-transporting ATPases".
Below are MeSH descriptors whose meaning is more specific than "Copper-transporting ATPases".
This graph shows the total number of publications written about "Copper-transporting ATPases" by people in this website by year, and whether "Copper-transporting ATPases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1997 | 0 | 3 | 3 |
| 1999 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Copper-transporting ATPases" by people in Profiles.
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Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis. Mol Cancer Ther. 2019 05; 18(5):873-885.
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Prenatal diagnostic conundrum involving a novel ATP7A duplication. Clin Genet. 2013 Jul; 84(1):97-8.
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Role of copper transporters in resistance to platinating agents. Cancer Chemother Pharmacol. 2009 Jun; 64(1):133-42.
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Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice. Am J Pathol. 2006 Feb; 168(2):423-34.
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Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p. J Biol Chem. 1999 Oct 01; 274(40):28497-504.
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Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation. Hum Mol Genet. 1999 Sep; 8(9):1665-71.
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The role of copper in neurodegenerative disease. Neurobiol Dis. 1999 Aug; 6(4):221-30.
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Heterologous expression of the metal-binding domains of human copper-transporting ATPases (P1-ATPases). Ann N Y Acad Sci. 1997 Nov 03; 834:155-7.
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Two forms of Wilson disease protein produced by alternative splicing are localized in distinct cellular compartments. Biochem J. 1997 Sep 15; 326 ( Pt 3):897-902.
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Identification and analysis of mutations in the Wilson disease gene (ATP7B): population frequencies, genotype-phenotype correlation, and functional analyses. Am J Hum Genet. 1997 Aug; 61(2):317-28.