"Jagged-1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serrate-jagged protein that functions as a ligand for NOTCH RECEPTORS. It may regulate CELL DIFFERENTIATION in HEMATOPOIESIS and PHYSIOLOGIC ANGIOGENESIS. Mutations in the Jagged-1 gene are associated with ALAGILLE SYNDROME 1.
- Jagged-1 Protein
- Jagged 1 Protein
- Alagille Syndrome Protein
- Jagged1 Protein
- Serrate1 Protein
- Jagged 1
- Serrate-1 Protein
- Serrate 1 Protein
- CD339 Antigen
- Antigen, CD339
Below are MeSH descriptors whose meaning is more general than "Jagged-1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Jagged-1 Protein".
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Below are the most recent publications written about "Jagged-1 Protein" by people in Profiles.
Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev. 2016 Feb; 139:65-73.
Vascular endothelial growth factor (VEGF) induced proliferation of human fetal derived ciliary epithelium stem cells is mediated by jagged-N cadherin pathway. Curr Neurovasc Res. 2013 May; 10(2):93-102.
Notch-1 and notch-4 receptors as prognostic markers in breast cancer. Int J Surg Pathol. 2011 Oct; 19(5):607-13.
Progression of intracranial glioma disrupts thymic homeostasis and induces T-cell apoptosis in vivo. Cancer Immunol Immunother. 2008 Dec; 57(12):1807-16.
Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation. J Virol. 2005 Jun; 79(12):7889-98.
Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. J Virol. 2004 Aug; 78(16):8687-700.
Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice. Curr Biol. 2002 Sep 17; 12(18):1605-10.
The p53 family member genes are involved in the Notch signal pathway. J Biol Chem. 2002 Jan 04; 277(1):719-24.
The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti. Hum Mol Genet. 2001 Mar 01; 10(5):507-12.
Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell. 1991 Nov 15; 67(4):687-99.