Solute Carrier Family 22 Member 5
"Solute Carrier Family 22 Member 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A high-affinity, ATP-binding, co-transporter for CARNITINE that is highly expressed in kidney, skeletal muscle, heart, and placental tissues. It transports one sodium ion with one carnitine molecule. It has a lower affinity for other organic cations and transports them independently of sodium. Mutations in the SLC22A5 gene are associated with systemic carnitine deficiency.
| Descriptor ID |
D000074058
|
| MeSH Number(s) |
D12.776.157.530.450.250.812.750 D12.776.157.530.937.612.750 D12.776.543.585.450.250.812.750 D12.776.543.585.937.701.750
|
| Concept/Terms |
Solute Carrier Family 22 Member 5- Solute Carrier Family 22 Member 5
- High-Affinity Carnitine Transporter
- Carnitine Transporter, High-Affinity
- High Affinity Carnitine Transporter
- Transporter, High-Affinity Carnitine
- OCTN2 Protein
- Sodium-Dependent Carnitine Cotransporter
- Carnitine Cotransporter, Sodium-Dependent
- Sodium Dependent Carnitine Cotransporter
- Organic Cation-Carnitine Transporter 2
- Organic Cation Carnitine Transporter 2
- SLC22A5 Protein
|
Below are MeSH descriptors whose meaning is more general than "Solute Carrier Family 22 Member 5".
Below are MeSH descriptors whose meaning is more specific than "Solute Carrier Family 22 Member 5".
This graph shows the total number of publications written about "Solute Carrier Family 22 Member 5" by people in this website by year, and whether "Solute Carrier Family 22 Member 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Solute Carrier Family 22 Member 5" by people in Profiles.
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Cytokine regulation of OCTN2 expression and activity in small and large intestine. Inflamm Bowel Dis. 2011 Apr; 17(4):907-16.
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The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe. 2007 Jun 14; 1(4):299-308.
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An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet. 2003 Dec; 35(4):341-8.