"Aldo-Keto Reductases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.
| Descriptor ID |
D000074408
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| MeSH Number(s) |
D08.811.682.047.150.700.156 D08.811.682.047.820.284
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| Concept/Terms |
Aldo-Keto Reductases- Aldo-Keto Reductases
- Aldo Keto Reductases
- Reductases, Aldo-Keto
- Aldo-Keto Reductase Superfamily
- Aldo Keto Reductase Superfamily
- Aldo-Keto Reductase Family
- Aldo Keto Reductase Family
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Below are MeSH descriptors whose meaning is more general than "Aldo-Keto Reductases".
Below are MeSH descriptors whose meaning is more specific than "Aldo-Keto Reductases".
This graph shows the total number of publications written about "Aldo-Keto Reductases" by people in this website by year, and whether "Aldo-Keto Reductases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aldo-Keto Reductases" by people in Profiles.
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Identification of candidate predictive markers of anticancer drug sensitivity using a panel of human cancer cell lines. Cancer Sci. 2003 Dec; 94(12):1074-82.
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Redox cycling of polycyclic aromatic hydrocarbon o-quinones: metal ion-catalyzed oxidation of catechols bypasses inhibition by superoxide dismutase. Chem Biol Interact. 1998 Oct 02; 115(3):201-13.
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Studies on three reductases which have polycyclic aromatic hydrocarbon quinones as substrates. Arch Biochem Biophys. 1993 Jun; 303(2):394-401.
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Polycyclic aromatic hydrocarbon quinone-mediated oxidation reduction cycling catalyzed by a human placental NADPH-linked carbonyl reductase. Arch Biochem Biophys. 1991 Dec; 291(2):334-8.