NAV1.2 Voltage-Gated Sodium Channel
"NAV1.2 Voltage-Gated Sodium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A voltage-gated sodium channel subtype that mediates the sodium ion permeability of excitable membranes. Defects in the SCN2A gene which codes for the alpha subunit of this sodium channel are associated with benign familial infantile seizures type 3, and early infantile epileptic encephalopathy type 11.
| Descriptor ID |
D062551
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| MeSH Number(s) |
D12.776.157.530.400.875.750.200 D12.776.543.550.450.875.750.200 D12.776.543.585.400.875.750.200 D12.776.631.960.200
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| Concept/Terms |
NAV1.2 Voltage-Gated Sodium Channel- NAV1.2 Voltage-Gated Sodium Channel
- NAV1.2 Voltage Gated Sodium Channel
- Type 2 Voltage-Gated Sodium Channel
- Type 2 Voltage Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 2
- Voltage Gated Sodium Channel Type 2
Voltage-Gated Sodium Channel Type 2 Subunit alpha- Voltage-Gated Sodium Channel Type 2 Subunit alpha
- Voltage Gated Sodium Channel Type 2 Subunit alpha
- Voltage-Gated Sodium Channel Type 2 alpha Subunit
- Voltage Gated Sodium Channel Type 2 alpha Subunit
- Sodium Channel, Voltage-Gated, Type II, alpha 1 Subunit
- Sodium Channel Protein Type 2 Subunit alpha
- Sodium Channel, Voltage-Gated, Type II, alpha 1
- NAV1.2 alpha Subunit
- SCN2A Sodium Channel alpha Subunit
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Below are MeSH descriptors whose meaning is more general than "NAV1.2 Voltage-Gated Sodium Channel".
Below are MeSH descriptors whose meaning is more specific than "NAV1.2 Voltage-Gated Sodium Channel".
This graph shows the total number of publications written about "NAV1.2 Voltage-Gated Sodium Channel" by people in this website by year, and whether "NAV1.2 Voltage-Gated Sodium Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "NAV1.2 Voltage-Gated Sodium Channel" by people in Profiles.
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Missense mutations in the membrane domain of PRRT2 affect its interaction with Nav1.2 voltage-gated sodium channels. Neurobiol Dis. 2023 07; 183:106177.
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SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. Elife. 2016 12 28; 5.
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Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity. Biochemistry. 2003 Dec 16; 42(49):14515-21.
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Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit. Eur J Biochem. 2003 Dec; 270(23):4762-70.