NAV1.1 Voltage-Gated Sodium Channel
"NAV1.1 Voltage-Gated Sodium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A voltage-gated sodium channel subtype that is predominantly expressed in the CENTRAL NERVOUS SYSTEM. Defects in the SCN1A gene which codes for the alpha subunit of this sodium channel are associated with DRAVET SYNDROME, generalized epilepsy with febrile seizures plus, type 2 (GEFS+2), and familial hemiplegic migraine type 3.
| Descriptor ID |
D062550
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| MeSH Number(s) |
D12.776.157.530.400.875.750.100 D12.776.543.550.450.875.750.100 D12.776.543.585.400.875.750.100 D12.776.631.960.100
|
| Concept/Terms |
NAV1.1 Voltage-Gated Sodium Channel- NAV1.1 Voltage-Gated Sodium Channel
- NAV1.1 Voltage Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 1
- Voltage Gated Sodium Channel Type 1
- Type 1 Voltage-Gated Sodium Channel
- Type 1 Voltage Gated Sodium Channel
Voltage-Gated Sodium Channel Type 1 Subunit alpha- Voltage-Gated Sodium Channel Type 1 Subunit alpha
- Voltage Gated Sodium Channel Type 1 Subunit alpha
- Sodium Channel, Voltage-Gated, Type I, alpha Protein
- SCN1A Sodium Channel alpha Subunit
- Voltage-Gated Sodium Channel Type 1 alpha Subunit
- Voltage Gated Sodium Channel Type 1 alpha Subunit
- NAV1.1 alpha Subunit
- alpha Subunit, NAV1.1
|
Below are MeSH descriptors whose meaning is more general than "NAV1.1 Voltage-Gated Sodium Channel".
Below are MeSH descriptors whose meaning is more specific than "NAV1.1 Voltage-Gated Sodium Channel".
This graph shows the total number of publications written about "NAV1.1 Voltage-Gated Sodium Channel" by people in this website by year, and whether "NAV1.1 Voltage-Gated Sodium Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 2 | 3 |
| 2023 | 0 | 1 | 1 |
| 2025 | 2 | 0 | 2 |
| 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "NAV1.1 Voltage-Gated Sodium Channel" by people in Profiles.
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Engineering a human-based translational activator for targeted protein expression restoration. Nucleic Acids Res. 2026 Feb 05; 54(4).
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Efficacy of Dravet Syndrome Treatments in a Subset of Individuals with 2q24.3 Deletion: A-5 Patient Case Series. J Child Neurol. 2026 10; 41(9):1331-1335.
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Interneuron-specific dual-AAV SCN1A gene replacement corrects epileptic phenotypes in mouse models of Dravet syndrome. Sci Transl Med. 2025 03 19; 17(790):eadn5603.
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Antisense oligonucleotides modulate aberrant inclusion of poison exons in SCN1A-related Dravet syndrome. JCI Insight. 2025 02 13; 10(7).
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Core Features Differentiate Dravet Syndrome from Febrile Seizures. J Pediatr. 2023 07; 258:113416.
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Aberrant Inclusion of a Poison Exon Causes Dravet Syndrome and Related SCN1A-Associated Genetic Epilepsies. Am J Hum Genet. 2018 12 06; 103(6):1022-1029.
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Dravet syndrome in South African infants: Tools for an early diagnosis. Seizure. 2018 Nov; 62:99-105.
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Severe peri-ictal respiratory dysfunction is common in Dravet syndrome. J Clin Invest. 2018 03 01; 128(3):1141-1153.
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Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype. Neurology. 2017 Sep 05; 89(10):1035-1042.
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A targeted resequencing gene panel for focal epilepsy. Neurology. 2016 Apr 26; 86(17):1605-12.