"Aurora Kinase A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION.
| Descriptor ID |
D064096
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.103.500 D12.776.167.049.500
|
| Concept/Terms |
Aurora Kinase A- Aurora Kinase A
- Aurora A Kinase
- Aurora A Kinases
- Aurora Kinases A
- STK15 Kinase
- AURORA2 Protein
- AuroraA Kinase
- Breast-Tumor-Amplified Kinase
- Breast Tumor Amplified Kinase
- BTAK Protein
- Serine-Threonine Protein Kinase 15
- Serine Threonine Protein Kinase 15
- AURKA
- Aurora-A Kinase
|
Below are MeSH descriptors whose meaning is more general than "Aurora Kinase A".
Below are MeSH descriptors whose meaning is more specific than "Aurora Kinase A".
This graph shows the total number of publications written about "Aurora Kinase A" by people in this website by year, and whether "Aurora Kinase A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aurora Kinase A" by people in Profiles.
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Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation. Elife. 2022 12 19; 11.
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MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer. Nat Commun. 2020 01 17; 11(1):338.
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Allosteric modulation of a human protein kinase with monobodies. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):13937-13942.
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Aurora Kinase A Inhibition Provides Clinical Benefit, Normalizes Megakaryocytes, and Reduces Bone Marrow Fibrosis in Patients with Myelofibrosis: A Phase I Trial. Clin Cancer Res. 2019 Aug 15; 25(16):4898-4906.
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A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers. Clin Cancer Res. 2019 01 01; 25(1):43-51.
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Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition. Nat Med. 2015 Dec; 21(12):1473-80.
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Targeting aurora kinase A inhibits hypoxia-mediated neuroblastoma cell tumorigenesis. Anticancer Res. 2014 May; 34(5):2269-74.
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Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma. J Pediatr Surg. 2014 Jan; 49(1):159-65.
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AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study. Cancer Epidemiol Biomarkers Prev. 2007 Jul; 16(7):1416-21.
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BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem. 2004 May 07; 279(19):19643-8.