"Filamins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.
| Descriptor ID |
D064448
|
| MeSH Number(s) |
A11.284.430.214.190.750.050.414 D05.750.078.730.315 D12.776.210.249 D12.776.220.525.315
|
| Concept/Terms |
Filamin B- Filamin B
- beta-Filamin
- beta Filamin
- beta-Filamins
- Filamin 1-Like Protein
- 1-Like Protein, Filamin
- 1-Like Proteins, Filamin
- Filamin 1 Like Protein
- Filamin 1-Like Proteins
- Protein, Filamin 1-Like
- Proteins, Filamin 1-Like
Filamin A- Filamin A
- Filamin 1
- alpha-Filamin
- alpha Filamin
- alpha-Filamins
- 280 kDa Actin-Binding Protein
- 280 kDa Actin Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "Filamins".
Below are MeSH descriptors whose meaning is more specific than "Filamins".
This graph shows the total number of publications written about "Filamins" by people in this website by year, and whether "Filamins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 4 | 4 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2024 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Filamins" by people in Profiles.
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Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias. J Am Heart Assoc. 2024 May 21; 13(10):e030467.
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Filament rigidity and connectivity tune the deformation modes of active biopolymer networks. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):E10037-E10045.
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Liquid behavior of cross-linked actin bundles. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2131-2136.
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Phenotype and genotype in patients with Larsen syndrome: clinical homogeneity and allelic heterogeneity in seven patients. BMC Med Genet. 2016 Apr 06; 17:27.
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Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res. 2012 Oct 01; 96(1):109-19.
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Heart failure-associated changes in RNA splicing of sarcomere genes. Circ Cardiovasc Genet. 2010 Apr; 3(2):138-46.
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Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancement. Cell Signal. 2009 Dec; 21(12):1945-60.
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Chapter 19: Mechanical response of cytoskeletal networks. Methods Cell Biol. 2008; 89:487-519.
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Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19836-41.
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Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations. Brain. 2006 Jul; 129(Pt 7):1892-906.