 Dynorphins
"Dynorphins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.
| Descriptor ID |
D004399
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| MeSH Number(s) |
D12.644.400.575.180 D12.644.468.180 D12.776.641.650.575.180
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dynorphins".
Below are MeSH descriptors whose meaning is more specific than "Dynorphins".
This graph shows the total number of publications written about "Dynorphins" by people in this website by year, and whether "Dynorphins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 | | 1994 | 1 | 1 | 2 | | 1995 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dynorphins" by people in Profiles.
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Hawes SL, Salinas AG, Lovinger DM, Blackwell KT. Long-term plasticity of corticostriatal synapses is modulated by pathway-specific co-release of opioids through ?-opioid receptors. J Physiol. 2017 08 15; 595(16):5637-5652.
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Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron. 2014 May 07; 82(3):573-86.
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Ding Y, Restrepo J, Won L, Hwang DY, Kim KS, Kang UJ. Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson's disease. Neurobiol Dis. 2007 Jul; 27(1):11-23.
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Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Petroff E, Turner JR, Rahme LG, Chang E, Alverdy JC. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog. 2007 Mar; 3(3):e35.
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Jacobson DA, Cho J, Landa LR, Tamarina NA, Roe MW, Buxbaum JD, Philipson LH. Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression. Am J Physiol Endocrinol Metab. 2006 Sep; 291(3):E587-95.
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Zhang D, Zhang L, Tang Y, Zhang Q, Lou D, Sharp FR, Zhang J, Xu M. Repeated cocaine administration induces gene expression changes through the dopamine D1 receptors. Neuropsychopharmacology. 2005 Aug; 30(8):1443-54.
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Woltman SJ, Even WR, Weber SG. Chromatographic detection using tris(2,2'-bipyridyl)ruthenium(III) as a fluorogenic electron-transfer reagent. Anal Chem. 1999 Apr 15; 71(8):1504-12.
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Ma GH, Miller RJ, Kuznetsov A, Philipson LH. kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes. Mol Pharmacol. 1995 May; 47(5):1035-40.
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Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonegawa S. Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell. 1994 Nov 18; 79(4):729-42.
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DePaoli AM, Hurley KM, Yasada K, Reisine T, Bell G. Distribution of kappa opioid receptor mRNA in adult mouse brain: an in situ hybridization histochemistry study. Mol Cell Neurosci. 1994 Aug; 5(4):327-35.
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