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Ming Xu

TitleProfessor
InstitutionUniversity of Chicago
DepartmentAnesthesia and Critical Care
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    My long-term research interest is to understand mechanisms underlying drug addiction and to find possible treatment. We use behavioral, genetic, anatomical and molecular biological methods. One major research project is to identify mechanisms and neuronal circuits associated with reconsolidation and extinction of cocaine-induced reward memory. Another project is to develop a novel method of using skin stem cells to deliver therapeutic genes to combat the abuse of cocaine, ethanol, nicotine and their co-abuse.
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    Collapse Biography 
    Collapse education and training
    Peking University, Beijing, P.R. ChinaBS01/1982Chemistry
    University of Texas Southwestern Medical Center, Dallas, TXPh.D.03/1989Molecular Biology
    Massachusetts Institute of Technology, Boston, MApostdoc12/1995Neurobiology

    Collapse Research 
    Collapse research activities and funding
    R01DA047785     (WU, XIAOYANG ;XU, MING)Sep 30, 2019 - Jul 31, 2024
    NIH
    A cutaneous gene therapy for cocaine abuse and alcohol co-abuse
    Role: Principal Investigator
    R21AA027172     (XU, MING)Sep 5, 2018 - Aug 31, 2020
    NIH
    A Novel cutaneous gene therapy for combating alcohol use disorder
    Role: Principal Investigator
    R21DA036921     (XU, MING)Feb 1, 2015 - Aug 31, 2017
    NIH
    A novel tool for studying D3 receptors and cocaine reward
    Role: Principal Investigator
    R01DA025088     (XU, MING)Apr 15, 2009 - Mar 31, 2015
    NIH
    Extinction of cue-elicited cocaine seeking
    Role: Principal Investigator
    R01DA017323     (XU, MING)Sep 1, 2005 - Jan 31, 2012
    NIH
    Role of c-fos in cocaine actions
    Role: Principal Investigator
    R01DA014644     (XU, MING)Sep 30, 2001 - Feb 28, 2008
    NIH
    Molecular Determinants of Compulsive Cocaine-Taking
    Role: Principal Investigator
    R01DA013786     (XU, MING)Sep 28, 2000 - Apr 30, 2005
    NIH
    LONG TERM COCAINE INDUCED CHANGES VIA DOPAMINE RECEPTORS
    Role: Principal Investigator
    R29DA011005     (XU, MING)May 1, 1997 - Mar 31, 2002
    NIH
    C-FOS AND PSYCHOMOTOR STIMULANT ACTIONS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kong Q, Li Y, Yue J, Wu X, Xu M. Reducing alcohol and/or cocaine-induced reward and toxicity via an epidermal stem cell-based gene delivery platform. Mol Psychiatry. 2021 09; 26(9):5266-5276. PMID: 33619338; PMCID: PMC8380265.
      Citations: 3     Fields:    Translation:AnimalsCells
    2. Kim YJ, Kong Q, Yamamoto S, Kuramoto K, Huang M, Wang N, Hong JH, Xiao T, Levine B, Qiu X, Zhao Y, Miller RJ, Dong H, Meltzer HY, Xu M, He C. An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system. Sci Adv. 2021 02; 7(8). PMID: 33608268; PMCID: PMC7895433.
      Citations: 5     Fields:    Translation:Animals
    3. Wang CZ, Wan JY, Wan J, Wang S, Luo Y, Zeng J, Yao H, Zhang CF, Zhang QH, Sawadogo WR, Xu M, Du W, Qi LW, Li P, Yuan CS. Human intestinal microbiota derived metabolism signature from a North American native botanical Oplopanax horridus with UPLC/Q-TOF-MS analysis. Biomed Chromatogr. 2020 Oct; 34(10):e4911. PMID: 32496571.
      Citations: 2     Fields:    Translation:HumansAnimals
    4. Wang CZ, Zhang CF, Zhang QH, Hesse-Fong J, Lager M, Du W, Xu M, Yuan CS. Fecal metabolomic dataset of American ginseng-treated DSS mice: Correlation between ginseng enteric inflammation inhibition and its biological signatures. Data Brief. 2018 Dec; 21:1403-1408. PMID: 30456264; PMCID: PMC6234249.
      Citations: 3     
    5. Li Y, Kong Q, Yue J, Gou X, Xu M, Wu X. Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose. Nat Biomed Eng. 2019 Feb; 3(2):105-113. PMID: 30899600; PMCID: PMC6423967.
      Citations: 15     Fields:    
    6. . Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose. Nature Biomedical Engineering. 2018. View Publication.
    7. Wang CZ, Yao H, Zhang CF, Chen L, Wan JY, Huang WH, Zeng J, Zhang QH, Liu Z, Yuan J, Bi Y, Sava-Segal C, Du W, Xu M, Yuan CS. American ginseng microbial metabolites attenuate DSS-induced colitis and abdominal pain. Int Immunopharmacol. 2018 Nov; 64:246-251. PMID: 30212750.
      Citations: 15     Fields:    Translation:HumansAnimals
    8. Kesarwani M, Kincaid Z, Gomaa A, Huber E, Rohrabaugh S, Siddiqui Z, Bouso MF, Latif T, Xu M, Komurov K, Mulloy JC, Cancelas JA, Grimes HL, Azam M. Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia. Nat Med. 2017 Apr; 23(4):472-482. PMID: 28319094; PMCID: PMC5424814.
      Citations: 53     Fields:    Translation:HumansAnimals
    9. Xu M, Solís O, Garcia-Montes JR, González-Granillo A, Moratalla R. Dopamine D3 Receptor Modulates l-DOPA-Induced Dyskinesia by Targeting D1 Receptor-Mediated Striatal Signaling. Cereb Cortex. 2017 01 01; 27(1):435-446. PMID: 26483399; PMCID: PMC5939228.
      Citations: 48     Fields:    Translation:Animals
    10. Soto PL, Hiranita T, Xu M, Hursh SR, Grandy DK, Katz JL. Dopamine D2-Like Receptors and Behavioral Economics of Food Reinforcement. Neuropsychopharmacology. 2016 Mar; 41(4):971-8. PMID: 26205210; PMCID: PMC4748422.
      Citations: 12     Fields:    Translation:Animals
    11. Yan Y, Newman AH, Xu M. Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration. Neuroscience. 2014 Oct 10; 278:154-64. PMID: 25149631; PMCID: PMC4172503.
      Citations: 12     Fields:    Translation:Animals
    12. Laronda MM, Duncan FE, Hornick JE, Xu M, Pahnke JE, Whelan KA, Shea LD, Woodruff TK. Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue. J Assist Reprod Genet. 2014 Aug; 31(8):1013-28. PMID: 24845158; PMCID: PMC4130945.
      Citations: 55     Fields:    Translation:HumansCells
    13. Zhang A, Xu M, Mo YY. Role of the lncRNA-p53 regulatory network in cancer. J Mol Cell Biol. 2014 Jun; 6(3):181-91. PMID: 24721780; PMCID: PMC4034727.
      Citations: 90     Fields:    Translation:Humans
    14. Zhang X, Zhang W, Ma SF, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Nourai M, Wade MS, Prchal JT, Garcia JGN, Machado RF, Gordeuk VR. Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing. Blood Cells Mol Dis. 2014 Jan; 52(1):35-45. PMID: 23993337; PMCID: PMC3852195.
      Citations: 14     Fields:    Translation:HumansCells
    15. Yan Y, Kong H, Wu EJ, Newman AH, Xu M. Dopamine D3 receptors regulate reconsolidation of cocaine memory. Neuroscience. 2013 Jun 25; 241:32-40. PMID: 23506736; PMCID: PMC3646898.
      Citations: 8     Fields:    Translation:Animals
    16. Shao W, Zhang SZ, Tang M, Zhang XH, Zhou Z, Yin YQ, Zhou QB, Huang YY, Liu YJ, Wawrousek E, Chen T, Li SB, Xu M, Zhou JN, Hu G, Zhou JW. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via aB-crystallin. Nature. 2013 Feb 07; 494(7435):90-4. PMID: 23242137.
      Citations: 190     Fields:    Translation:AnimalsCells
    17. Cao G, Zhu J, Zhong Q, Shi C, Dang Y, Han W, Liu X, Xu M, Chen T. Distinct roles of methamphetamine in modulating spatial memory consolidation, retrieval, reconsolidation and the accompanying changes of ERK and CREB activation in hippocampus and prefrontal cortex. Neuropharmacology. 2013 Apr; 67:144-54. PMID: 23159329; PMCID: PMC3582331.
      Citations: 26     Fields:    Translation:AnimalsCells
    18. Jiao ZX, Xu M, Woodruff TK. Age-associated alteration of oocyte-specific gene expression in polar bodies: potential markers of oocyte competence. Fertil Steril. 2012 Aug; 98(2):480-6. PMID: 22633262; PMCID: PMC3409302.
      Citations: 12     Fields:    Translation:AnimalsCells
    19. Xu M, Pavone ME, Woodruff T. Fruitful progress to fertility: preserving oocytes from chemodestruction. Nat Med. 2011 Dec 06; 17(12):1562-3. PMID: 22146461.
      Citations: 7     Fields:    Translation:HumansCells
    20. Shikanov A, Zhang Z, Xu M, Smith RM, Rajan A, Woodruff TK, Shea LD. Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice. Tissue Eng Part A. 2011 Dec; 17(23-24):3095-104. PMID: 21740332; PMCID: PMC3226061.
      Citations: 59     Fields:    Translation:HumansAnimals
    21. Antenos M, Lei L, Xu M, Malipatil A, Kiesewetter S, Woodruff TK. Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin a- and ß-subunits as candidate substrates. PLoS One. 2011 Mar 08; 6(3):e17348. PMID: 21408162; PMCID: PMC3050889.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    22. Kong H, Xu M. Exploring mechanisms underlying extinction of cue-elicited cocaine seeking. Curr Neuropharmacol. 2011 Mar; 9(1):8-11. PMID: 21886552; PMCID: PMC3137207.
      Citations: 1     Fields:    
    23. Kong H, Kuang W, Li S, Xu M. Activation of dopamine D3 receptors inhibits reward-related learning induced by cocaine. Neuroscience. 2011 Mar 10; 176:152-61. PMID: 21168475; PMCID: PMC3040280.
      Citations: 15     Fields:    Translation:AnimalsCells
    24. Xu M, Fazleabas AT, Shikanov A, Jackson E, Barrett SL, Hirshfeld-Cytron J, Kiesewetter SE, Shea LD, Woodruff TK. In vitro oocyte maturation and preantral follicle culture from the luteal-phase baboon ovary produce mature oocytes. Biol Reprod. 2011 Apr; 84(4):689-97. PMID: 21123815; PMCID: PMC3062036.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    25. Chen L, Xu M. Dopamine D1 and D3 receptors are differentially involved in cue-elicited cocaine seeking. J Neurochem. 2010 Jul; 114(2):530-41. PMID: 20456009; PMCID: PMC2910121.
      Citations: 20     Fields:    Translation:AnimalsCells
    26. Ren Z, Sun WL, Jiao H, Zhang D, Kong H, Wang X, Xu M. Dopamine D1 and N-methyl-D-aspartate receptors and extracellular signal-regulated kinase mediate neuronal morphological changes induced by repeated cocaine administration. Neuroscience. 2010 Jun 16; 168(1):48-60. PMID: 20346392; PMCID: PMC2871972.
      Citations: 38     Fields:    Translation:AnimalsCells
    27. Fan X, Xu M, Hess EJ. D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD. Neurobiol Dis. 2010 Jan; 37(1):228-36. PMID: 19840852; PMCID: PMC2839459.
      Citations: 21     Fields:    Translation:AnimalsCells
    28. Zhou FW, Jin Y, Matta SG, Xu M, Zhou FM. An ultra-short dopamine pathway regulates basal ganglia output. J Neurosci. 2009 Aug 19; 29(33):10424-35. PMID: 19692618; PMCID: PMC3596265.
      Citations: 52     Fields:    Translation:AnimalsCells
    29. Shikanov A, Xu M, Woodruff TK, Shea LD. Interpenetrating fibrin-alginate matrices for in vitro ovarian follicle development. Biomaterials. 2009 Oct; 30(29):5476-85. PMID: 19616843; PMCID: PMC2906124.
      Citations: 99     Fields:    Translation:AnimalsCells
    30. Xu M, Barrett SL, West-Farrell E, Kondapalli LA, Kiesewetter SE, Shea LD, Woodruff TK. In vitro grown human ovarian follicles from cancer patients support oocyte growth. Hum Reprod. 2009 Oct; 24(10):2531-40. PMID: 19597190; PMCID: PMC2743446.
      Citations: 117     Fields:    Translation:HumansCells
    31. Xu M, Banc A, Woodruff TK, Shea LD. Secondary follicle growth and oocyte maturation by culture in alginate hydrogel following cryopreservation of the ovary or individual follicles. Biotechnol Bioeng. 2009 Jun 01; 103(2):378-86. PMID: 19191350; PMCID: PMC2778231.
      Citations: 61     Fields:    Translation:AnimalsCells
    32. Xu M, West-Farrell ER, Stouffer RL, Shea LD, Woodruff TK, Zelinski MB. Encapsulated three-dimensional culture supports development of nonhuman primate secondary follicles. Biol Reprod. 2009 Sep; 81(3):587-94. PMID: 19474063; PMCID: PMC2731985.
      Citations: 88     Fields:    Translation:AnimalsCells
    33. Campioni MR, Xu M, McGehee DS. Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurophysiol. 2009 Jun; 101(6):3192-8. PMID: 19357347; PMCID: PMC3817271.
      Citations: 62     Fields:    Translation:AnimalsCells
    34. Liu XY, Mao LM, Zhang GC, Papasian CJ, Fibuch EE, Lan HX, Zhou HF, Xu M, Wang JQ. Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII. Neuron. 2009 Feb 12; 61(3):425-38. PMID: 19217379; PMCID: PMC2650276.
      Citations: 70     Fields:    Translation:AnimalsCells
    35. Hu XT, Nasif FJ, Zhang J, Xu M. Fos regulates neuronal activity in the nucleus accumbens. Neurosci Lett. 2008 Dec 19; 448(1):157-60. PMID: 18938216; PMCID: PMC2605784.
      Citations: 3     Fields:    Translation:AnimalsCells
    36. Caine SB, Thomsen M, Gabriel KI, Berkowitz JS, Gold LH, Koob GF, Tonegawa S, Zhang J, Xu M. Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci. 2007 Nov 28; 27(48):13140-50. PMID: 18045908; PMCID: PMC2747091.
      Citations: 98     Fields:    Translation:Animals
    37. Jiao H, Zhang L, Gao F, Lou D, Zhang J, Xu M. Dopamine D(1) and D(3) receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation. J Neurochem. 2007 Oct; 103(2):840-8. PMID: 17897358.
      Citations: 31     Fields:    Translation:AnimalsCells
    38. Shi J, Zhao Y, Ishii T, Hu W, Sozer S, Zhang W, Bruno E, Lindgren V, Xu M, Hoffman R. Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis. Cancer Res. 2007 Jul 01; 67(13):6417-24. PMID: 17616702.
      Citations: 24     Fields:    Translation:HumansCells
    39. Ciurea SO, Merchant D, Mahmud N, Ishii T, Zhao Y, Hu W, Bruno E, Barosi G, Xu M, Hoffman R. Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis. Blood. 2007 Aug 01; 110(3):986-93. PMID: 17473062; PMCID: PMC1924766.
      Citations: 102     Fields:    Translation:HumansCellsCTClinical Trials
    40. Zhang J, Zhang L, Jiao H, Zhang Q, Zhang D, Lou D, Katz JL, Xu M. c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. J Neurosci. 2006 Dec 20; 26(51):13287-96. PMID: 17182779; PMCID: PMC6675013.
      Citations: 67     Fields:    Translation:Animals
    41. Cui C, Xu M, Atzori M. Voltage-dependent block of N-methyl-D-aspartate receptors by dopamine D1 receptor ligands. Mol Pharmacol. 2006 Nov; 70(5):1761-70. PMID: 16921022.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    42. Ishii T, Bruno E, Hoffman R, Xu M. Involvement of various hematopoietic-cell lineages by the JAK2V617F mutation in polycythemia vera. Blood. 2006 Nov 01; 108(9):3128-34. PMID: 16757685.
      Citations: 53     Fields:    Translation:HumansCells
    43. Araki H, Mahmud N, Milhem M, Nunez R, Xu M, Beam CA, Hoffman R. Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. Exp Hematol. 2006 Feb; 34(2):140-9. PMID: 16459182.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    44. Zhang D, Zhang L, Tang Y, Zhang Q, Lou D, Sharp FR, Zhang J, Xu M. Repeated cocaine administration induces gene expression changes through the dopamine D1 receptors. Neuropsychopharmacology. 2005 Aug; 30(8):1443-54. PMID: 15770241.
      Citations: 39     Fields:    Translation:Animals
    45. Xu M, Bruno E, Chao J, Huang S, Finazzi G, Fruchtman SM, Popat U, Prchal JT, Barosi G, Hoffman R, MPD Research Consortium. Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases. Blood. 2005 Jun 01; 105(11):4508-15. PMID: 15705794.
      Citations: 38     Fields:    Translation:HumansCells
    46. Xu M, Bruno E, Chao J, Ni H, Lindgren V, Nunez R, Mahmud N, Finazzi G, Fruchtman SM, Popat U, Liu E, Prchal JT, Rondelli D, Barosi G, Hoffman R. The constitutive mobilization of bone marrow-repopulating cells into the peripheral blood in idiopathic myelofibrosis. Blood. 2005 Feb 15; 105(4):1699-705. PMID: 15471948.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    47. Zhang L, Lou D, Jiao H, Zhang D, Wang X, Xia Y, Zhang J, Xu M. Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J Neurosci. 2004 Mar 31; 24(13):3344-54. PMID: 15056714; PMCID: PMC6730011.
      Citations: 107     Fields:    Translation:AnimalsCells
    48. Zhang J, Dong M, Li L, Fan Y, Pathre P, Dong J, Lou D, Wells JM, Van Kaer L, Wang X, Xu M, Olivares-Villagómez D. Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15782-7. PMID: 14663139; PMCID: PMC307645.
      Citations: 25     Fields:    Translation:AnimalsCells
    49. Zheng W, Xie W, Zhang J, Strong JA, Wang L, Yu L, Xu M, Lu L. Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord. J Biol Chem. 2003 Nov 28; 278(48):48321-9. PMID: 12970343.
      Citations: 11     Fields:    Translation:Animals
    50. Zhang J, McQuade JM, Vorhees CV, Xu M. Hippocampal expression of c-fos is not essential for spatial learning. Synapse. 2002 Nov; 46(2):91-9. PMID: 12211087.
      Citations: 10     Fields:    Translation:Animals
    51. Zhang D, Zhang L, Lou DW, Nakabeppu Y, Zhang J, Xu M, Zhang D, Zhang L, Lou DW, Nakabeppu Y, Zhang J, Xu M. The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression. J Neurochem. 2002 Sep; 82(6):1453-64. PMID: 12354293.
      Citations: 44     Fields:    Translation:Animals
    52. Zhang J, Zhang D, McQuade JS, Behbehani M, Tsien JZ, Xu M. c-fos regulates neuronal excitability and survival. Nat Genet. 2002 Apr; 30(4):416-20. PMID: 11925568.
      Citations: 109     Fields:    Translation:AnimalsCells
    53. Zhang J, Xu M, Zhang J, Xu M. Apoptotic DNA fragmentation and tissue homeostasis. Trends Cell Biol. 2002 Feb; 12(2):84-9. PMID: 11849972.
      Citations: 31     Fields:    Translation:HumansAnimals
    54. Boulares AH, Zoltoski AJ, Yakovlev A, Xu M, Smulson ME. Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. J Biol Chem. 2001 Oct 12; 276(41):38185-92. PMID: 11461900.
      Citations: 16     Fields:    Translation:AnimalsCells
    55. Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W. Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway. Blood. 2000 Jan 15; 95(2):633-8. PMID: 10627473.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    56. Xu M, Guo Y, Vorhees CV, Zhang J. Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. Brain Res. 2000 Jan 03; 852(1):198-207. PMID: 10661513.
      Citations: 49     Fields:    Translation:Animals
    57. Zhang J, Wang X, Bove KE, Xu M. DNA fragmentation factor 45-deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells. J Biol Chem. 1999 Dec 24; 274(52):37450-4. PMID: 10601318.
      Citations: 20     Fields:    Translation:AnimalsCells
    58. Dracheva S, Xu M, Kelley KA, Haroutunian V, Holstein GR, Haun S, Silverstein JH, Sealfon SC. Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice. Exp Neurol. 1999 May; 157(1):169-79. PMID: 10222120.
      Citations: 12     Fields:    Translation:Animals
    59. Zhang J, Liu X, Scherer DC, van Kaer L, Wang X, Xu M. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12480-5. PMID: 9770511; PMCID: PMC22856.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    60. Koeltzow TE, Xu M, Cooper DC, Hu XT, Tonegawa S, Wolf ME, White FJ. Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. J Neurosci. 1998 Mar 15; 18(6):2231-8. PMID: 9482807; PMCID: PMC6792939.
      Citations: 61     Fields:    Translation:AnimalsCells
    61. Xu M, Koeltzow TE, Santiago GT, Moratalla R, Cooper DC, Hu XT, White NM, Graybiel AM, White FJ, Tonegawa S. Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron. 1997 Oct; 19(4):837-48. PMID: 9354330.
      Citations: 82     Fields:    Translation:AnimalsCells
    62. Moratalla R, Xu M, Tonegawa S, Graybiel AM. Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14928-33. PMID: 8962158; PMCID: PMC26239.
      Citations: 48     Fields:    Translation:Animals
    63. Xu M, Hu XT, Cooper DC, Moratalla R, Graybiel AM, White FJ, Tonegawa S. Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell. 1994 Dec 16; 79(6):945-55. PMID: 8001143.
      Citations: 97     Fields:    Translation:AnimalsCells
    64. Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonegawa S. Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell. 1994 Nov 18; 79(4):729-42. PMID: 7954836.
      Citations: 122     Fields:    Translation:AnimalsCells
    65. Xu M, Hammer RE, Blasquez VC, Jones SL, Garrard WT. Immunoglobulin kappa gene expression after stable integration. II. Role of the intronic MAR and enhancer in transgenic mice. J Biol Chem. 1989 Dec 15; 264(35):21190-5. PMID: 2512291.
      Citations: 17     Fields:    Translation:AnimalsCells
    66. Blasquez VC, Xu M, Moses SC, Garrard WT. Immunoglobulin kappa gene expression after stable integration. I. Role of the intronic MAR and enhancer in plasmacytoma cells. J Biol Chem. 1989 Dec 15; 264(35):21183-9. PMID: 2512290.
      Citations: 24     Fields:    Translation:AnimalsCells
    67. Huang SY, Barnard MB, Xu M, Matsui S, Rose SM, Garrard WT. The active immunoglobulin kappa chain gene is packaged by non-ubiquitin-conjugated nucleosomes. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):3738-42. PMID: 3012532; PMCID: PMC323598.
      Citations: 11     Fields:    Translation:AnimalsCells
    68. Xu M, Barnard MB, Rose SM, Cockerill PN, Huang SY, Garrard WT. Transcription termination and chromatin structure of the active immunoglobulin kappa gene locus. J Biol Chem. 1986 Mar 15; 261(8):3838-45. PMID: 3081510.
      Citations: 25     Fields:    Translation:AnimalsCells
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