"Mice, SCID" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
| Descriptor ID |
D016513
|
| MeSH Number(s) |
B01.050.150.900.649.313.992.635.505.500.550.780
|
| Concept/Terms |
Mice, SCID- Mice, SCID
- Severe Combined Immunodeficient Mice
- SCID Mice
- Immunodeficient Mice, Severe Combined
- Mouse, SCID
- SCID Mouse
Mouse, SCID-hu- Mouse, SCID-hu
- Mouse, SCID hu
- SCID-hu Mouse
- SCID-hu Mice
- Mice, SCID-hu
- SCID hu Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, SCID".
Below are MeSH descriptors whose meaning is more specific than "Mice, SCID".
This graph shows the total number of publications written about "Mice, SCID" by people in this website by year, and whether "Mice, SCID" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 3 | 4 |
| 1995 | 0 | 7 | 7 |
| 1996 | 1 | 4 | 5 |
| 1997 | 3 | 3 | 6 |
| 1998 | 2 | 5 | 7 |
| 1999 | 0 | 4 | 4 |
| 2000 | 1 | 1 | 2 |
| 2001 | 0 | 6 | 6 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 7 | 7 |
| 2005 | 0 | 7 | 7 |
| 2006 | 0 | 8 | 8 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 5 | 5 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 12 | 12 |
| 2011 | 0 | 8 | 8 |
| 2012 | 0 | 11 | 11 |
| 2013 | 0 | 8 | 8 |
| 2014 | 0 | 10 | 10 |
| 2015 | 0 | 13 | 13 |
| 2016 | 0 | 14 | 14 |
| 2017 | 0 | 6 | 6 |
| 2018 | 0 | 14 | 14 |
| 2019 | 0 | 14 | 14 |
| 2020 | 0 | 5 | 5 |
| 2021 | 0 | 3 | 3 |
| 2022 | 0 | 3 | 3 |
| 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Mice, SCID" by people in Profiles.
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Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis. Science. 2024 Jun 21; 384(6702):eadh5548.
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Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD. Blood. 2024 01 11; 143(2):166-177.
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Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML. In Vivo. 2022 Jul-Aug; 36(4):1615-1627.
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Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models. Biomed Pharmacother. 2022 Mar; 147:112662.
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Positive and negative selection shape the human naive B cell repertoire. J Clin Invest. 2022 01 18; 132(2).
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Phase 1 study of anti-CD47 monoclonal antibody CC-90002 in patients with relapsed/refractory acute myeloid leukemia and high-risk myelodysplastic syndromes. Ann Hematol. 2022 Mar; 101(3):557-569.
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HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease. Mol Cell. 2021 12 16; 81(24):5052-5065.e6.
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Stimulation of an anti-tumor immune response with "chromatin-damaging" therapy. Cancer Immunol Immunother. 2021 Jul; 70(7):2073-2086.
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Synthesis, Tumor Specificity, and Photosensitizing Efficacy of Erlotinib-Conjugated Chlorins and Bacteriochlorins: Identification of a Highly Effective Candidate for Photodynamic Therapy of Cancer. J Med Chem. 2021 01 14; 64(1):741-767.
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Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy. Mol Cancer Ther. 2020 10; 19(10):2175-2185.