"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Descriptor ID |
D018345
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MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
|
Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 2 | 2 |
1995 | 0 | 5 | 5 |
1996 | 1 | 6 | 7 |
1997 | 0 | 13 | 13 |
1998 | 0 | 20 | 20 |
1999 | 0 | 20 | 20 |
2000 | 0 | 30 | 30 |
2001 | 0 | 31 | 31 |
2002 | 0 | 52 | 52 |
2003 | 0 | 50 | 50 |
2004 | 0 | 55 | 55 |
2005 | 0 | 44 | 44 |
2006 | 0 | 59 | 59 |
2007 | 0 | 59 | 59 |
2008 | 0 | 52 | 52 |
2009 | 0 | 81 | 81 |
2010 | 0 | 83 | 83 |
2011 | 0 | 73 | 73 |
2012 | 0 | 79 | 79 |
2013 | 0 | 69 | 69 |
2014 | 0 | 90 | 90 |
2015 | 0 | 83 | 83 |
2016 | 0 | 59 | 59 |
2017 | 0 | 70 | 70 |
2018 | 0 | 47 | 47 |
2019 | 0 | 56 | 56 |
2020 | 0 | 56 | 56 |
2021 | 0 | 41 | 41 |
2022 | 0 | 5 | 5 |
2023 | 0 | 7 | 7 |
2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
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Assessment of blood-brain barrier leakage and brain oxygenation in Connexin-32 knockout mice with systemic neuroinflammation using pulse electron paramagnetic resonance imaging techniques. Magn Reson Med. 2024 Jun; 91(6):2519-2531.
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The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix. JCI Insight. 2024 Jan 04; 9(3).
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Deletion of Endogenous Neuregulin-4 Limits Adaptive Immunity During Interleukin-10 Receptor-Neutralizing Colitis. Inflamm Bowel Dis. 2023 11 02; 29(11):1778-1792.
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Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice. Transplantation. 2023 11 01; 107(11):2353-2363.
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A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes. Nat Metab. 2023 05; 5(5):861-879.
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Iodotyrosines Are Biomarkers for Preclinical Stages of Iodine-Deficient Hypothyroidism in Dehal1-Knockout Mice. Thyroid. 2023 06; 33(6):752-761.
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Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing. Neuron. 2023 05 17; 111(10):1637-1650.e5.
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TMEM161B modulates radial glial scaffolding in neocortical development. Proc Natl Acad Sci U S A. 2023 01 24; 120(4):e2209983120.
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Palmitoylation couples insulin hypersecretion with ß cell failure in diabetes. Cell Metab. 2023 02 07; 35(2):332-344.e7.
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Ca2+ binding to synapsin I regulates resting Ca2+ and recovery from synaptic depression in nerve terminals. Cell Mol Life Sci. 2022 Nov 21; 79(12):600.