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Satish Chitneni

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentRadiology-Basic Sciences
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    Our research focuses primarily on developing molecularly targeted radiotracers for noninvasive imaging of various diseases and disease-related biomarkers using positron emission tomography (PET) and for targeted radiopharmaceutical therapy of cancers. For this, we employ a variety of molecular scaffolds, including small molecules, peptides, and antibodies, and radiolabel them with appropriate radionuclides, such as fluorine-18, radioiodines, or zirconium-89 for imaging. Once successfully validated, the resulting imaging agents can have wide-ranging applications in the diagnosis and treatment of specific diseases and aid in new drug development. The work involves a multidisciplinary approach and collaborations with several other experts, including chemists, biologists, physicists, and physicians, to successfully advance the most promising radiopharmaceutical products for human use.

    Collapse Biography 
    Collapse education and training
    Katholieke Universiteit Leuven (KU Leuven), BelgiumPhDRadiopharmaceutical Sciences
    Nuclear Pharmacist (ANP)

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Broder BA, Bhuiyan M, Freifelder R, Rotsch DA, Chitneni SK, Makinen MW, Chen CT. Efficient Synthesis and HPLC-Based Characterization for Developing Vanadium-48-Labeled Vanadyl Acetylacetonate as a Novel Cancer Radiotracer for PET Imaging. Molecules. 2024 Feb 09; 29(4). PMID: 38398551; PMCID: PMC10892645.
      Citations:    Fields:    Translation:Animals
    2. Meier JP, Zhang HJ, Freifelder R, Bhuiyan M, Selman P, Mendez M, Kankanamalage PHA, Brossard T, Pusateri A, Tsai HM, Leoni L, Penano S, Ghosh K, Broder BA, Markiewicz E, Renne A, Stadler W, Weichselbaum R, Nolen J, Kao CM, Chitneni SK, Rotsch DA, Szmulewitz RZ, Chen CT. Accelerator-Based Production of Scandium Radioisotopes for Applications in Prostate Cancer: Toward Building a Pipeline for Rapid Development of Novel Theranostics. Molecules. 2023 Aug 13; 28(16). PMID: 37630292; PMCID: PMC10458970.
      Citations: 3     Fields:    Translation:HumansAnimals
    3. Zhou Z, Zalutsky MR, Chitneni SK. Stapled peptides as scaffolds for developing radiotracers for intracellular targets: Preliminary evaluation of a radioiodinated MDM2-binding stapled peptide in the SJSA-1 osteosarcoma model. Bioorg Med Chem Lett. 2022 06 15; 66:128725. PMID: 35436588; PMCID: PMC9940446.
      Citations: 1     Fields:    Translation:HumansAnimals
    4. Zhou Z, Zalutsky MR, Chitneni SK. Fluorine-18 Labeling of the MDM2 Inhibitor RG7388 for PET Imaging: Chemistry and Preliminary Evaluation. Mol Pharm. 2021 10 04; 18(10):3871-3881. PMID: 34523337; PMCID: PMC8775362.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    5. Chitneni SK, Zhou Z, Watts BE, Zalutsky MR. Feasibility of Developing Radiotracers for MDM2: Synthesis and Preliminary Evaluation of an 18F-Labeled Analogue of the MDM2 Inhibitor SP-141. Pharmaceuticals (Basel). 2021 Apr 13; 14(4). PMID: 33924734; PMCID: PMC8070256.
      Citations: 2     
    6. Du K, Chitneni SK, Suzuki A, Wang Y, Henao R, Hyun J, Premont RT, Naggie S, Moylan CA, Bashir MR, Abdelmalek MF, Diehl AM. Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression. Cell Mol Gastroenterol Hepatol. 2020; 10(1):1-21. PMID: 31881361; PMCID: PMC7215180.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    7. Chitneni SK, Koumarianou E, Vaidyanathan G, Zalutsky MR. Observations on the Effects of Residualization and Dehalogenation on the Utility of N-Succinimidyl Ester Acylation Agents for Radioiodination of the Internalizing Antibody Trastuzumab. Molecules. 2019 Oct 30; 24(21). PMID: 31671554; PMCID: PMC6864793.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    8. Chitneni SK, Yan H, Zalutsky MR. Synthesis and Evaluation of a 18F-Labeled Triazinediamine Analogue for Imaging Mutant IDH1 Expression in Gliomas by PET. ACS Med Chem Lett. 2018 Jul 12; 9(7):606-611. PMID: 30034587; PMCID: PMC6047021.
      Citations: 13     
    9. Gedeon PC, Schaller TH, Chitneni SK, Choi BD, Kuan CT, Suryadevara CM, Snyder DJ, Schmittling RJ, Szafranski SE, Cui X, Healy PN, Herndon JE, McLendon RE, Keir ST, Archer GE, Reap EA, Sanchez-Perez L, Bigner DD, Sampson JH. A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma. Clin Cancer Res. 2018 08 01; 24(15):3611-3631. PMID: 29703821; PMCID: PMC6103776.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    10. Zhou Z, Chitneni SK, Devoogdt N, Zalutsky MR, Vaidyanathan G. Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation. Bioorg Med Chem. 2018 05 01; 26(8):1939-1949. PMID: 29534937; PMCID: PMC5891353.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    11. Chitneni SK, Reitman ZJ, Spicehandler R, Gooden DM, Yan H, Zalutsky MR. Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors. Bioorg Med Chem Lett. 2018 02 15; 28(4):694-699. PMID: 29366652; PMCID: PMC5817038.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    12. Chitneni SK, Reitman ZJ, Gooden DM, Yan H, Zalutsky MR. Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs. Eur J Med Chem. 2016 Aug 25; 119:218-30. PMID: 27163884; PMCID: PMC4893934.
      Citations: 12     Fields:    Translation:Animals
    13. Chitneni SK. IDH1 Mutations in Glioma: Considerations for Radiotracer Development. SM Radiol J. 2016; 2(1). PMID: 27158682; PMCID: PMC4857886.
      Citations: 1     
    14. Chitneni SK, Bida GT, Zalutsky MR, Dewhirst MW. Reply: Pharmacokinetic and Pharmacodynamic Modifiers of EF5 Uptake and Binding. J Nucl Med. 2015 Apr; 56(4):653-4. PMID: 25745087.
      Citations:    Fields:    Translation:HumansAnimals
    15. Safi R, Nelson ER, Chitneni SK, Franz KJ, George DJ, Zalutsky MR, McDonnell DP. Copper signaling axis as a target for prostate cancer therapeutics. Cancer Res. 2014 Oct 15; 74(20):5819-31. PMID: 25320179; PMCID: PMC4203427.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    16. Pruszynski M, Koumarianou E, Vaidyanathan G, Chitneni S, Zalutsky MR. D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination. Nucl Med Biol. 2015 Jan; 42(1):19-27. PMID: 25240914; PMCID: PMC4268387.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    17. Chitneni SK, Bida GT, Zalutsky MR, Dewhirst MW. Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models. J Nucl Med. 2014 Jul; 55(7):1192-7. PMID: 24854792; PMCID: PMC4241176.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    18. Akurathi V, Dubois L, Celen S, Lieuwes NG, Chitneni SK, Cleynhens BJ, Innocenti A, Supuran CT, Verbruggen AM, Lambin P, Bormans GM. Development and biological evaluation of ??mTc-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers. Eur J Med Chem. 2014 Jan; 71:374-84. PMID: 24378650.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    19. Chitneni SK, Bida GT, Yuan H, Palmer GM, Hay MP, Melcher T, Wilson WR, Zalutsky MR, Dewhirst MW. 18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model. J Nucl Med. 2013 Aug; 54(8):1339-46. PMID: 23740105; PMCID: PMC3770943.
      Citations: 17     Fields:    Translation:HumansAnimals
    20. Deroose CM, Chitneni SK, Gijsbers R, Vermaelen P, Ibrahimi A, Balzarini J, Baekelandt V, Verbruggen A, Nuyts J, Debyser Z, Bormans GM, Mortelmans L. Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET. Nucl Med Biol. 2012 Nov; 39(8):1266-74. PMID: 22981986.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    21. Chitneni SK, Bida GT, Dewhirst MW, Zalutsky MR. A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5). Nucl Med Biol. 2012 Oct; 39(7):1012-8. PMID: 22727821; PMCID: PMC3478693.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    22. Chitneni SK, Palmer GM, Zalutsky MR, Dewhirst MW. Molecular imaging of hypoxia. J Nucl Med. 2011 Feb; 52(2):165-8. PMID: 21233176; PMCID: PMC3500596.
      Citations: 35     Fields:    Translation:Humans
    23. Celen S, Koole M, De Angelis M, Sannen I, Chitneni SK, Alcazar J, Dedeurwaerdere S, Moechars D, Schmidt M, Verbruggen A, Langlois X, Van Laere K, Andrés JI, Bormans G. Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain. J Nucl Med. 2010 Oct; 51(10):1584-91. PMID: 20847170.
      Citations: 21     Fields:    Translation:Animals
    24. Akurathi V, Dubois L, Lieuwes NG, Chitneni SK, Cleynhens BJ, Vullo D, Supuran CT, Verbruggen AM, Lambin P, Bormans GM. Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia. Nucl Med Biol. 2010 Jul; 37(5):557-64. PMID: 20610160.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    25. Chitneni SK, Balzarini J, Celen S, Dyubankova N, Verbruggen AM, Bormans GM. . Synthesis and biological evaluation of carbon-11 labeled acyclic and furo[2,3-d]pyrimidine-derivatives of bicyclic nucleoside analogues (BCNAs) for structure-brain uptake relationship study of BCNA tracers. J. Label Compd. Radiopharm. 2008; 51(3):159-166.
    26. Celen S, Deroose C, de Groot T, Chitneni SK, Gijsbers R, Debyser Z, Mortelmans L, Verbruggen A, Bormans G. Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography. Bioconjug Chem. 2008 Feb; 19(2):441-9. PMID: 18179161.
      Citations: 11     Fields:    Translation:HumansCells
    27. Chitneni SK, Deroose CM, Balzarini J, Gijsbers R, Celen S, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression. J Med Chem. 2007 Dec 27; 50(26):6627-37. PMID: 18047266.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    28. Chitneni SK, Garreau L, Cleynhens B, Evens N, Bex M, Vermaelen P, Chalon S, Busson R, Guilloteau D, Van Laere K, Verbruggen A, Bormans G. Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [(18)F]FECT. Nucl Med Biol. 2008 Jan; 35(1):75-82. PMID: 18158946.
      Citations: 5     Fields:    Translation:Animals
    29. Chitneni SK, Serdons K, Evens N, Fonge H, Celen S, Deroose CM, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction. J Chromatogr A. 2008 May 02; 1189(1-2):323-31. PMID: 18045609.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    30. Fonge H, Chitneni SK, Lixin J, Vunckx K, Prinsen K, Nuyts J, Mortelmans L, Bormans G, Ni Y, Verbruggen A. Necrosis avidity of (99m)Tc(CO)3-labeled pamoic acid derivatives: synthesis and preliminary biological evaluation in animal models of necrosis. Bioconjug Chem. 2007 Nov-Dec; 18(6):1924-34. PMID: 17929883.
      Citations: 6     Fields:    Translation:AnimalsCells
    31. Chitneni SK, De Ruymaeker T, Balzarini J, Verbruggen AM, Bormans GM. Synthesis and biological evaluation of a lipophilic, fluorine-18-labeled 5-ethynyl-2'-deoxyuridine derivative. J. Label. Compd. Radiopharm. 2007; 50(7):649-655.
    32. Toelen J, Deroose CM, Gijsbers R, Reumers V, Sbragia LN, Vets S, Chitneni SK, Bormans G, Mortelmans L, Deprest JA, Debyser Z. Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model. Am J Obstet Gynecol. 2007 Apr; 196(4):352.e1-6. PMID: 17403419.
      Citations: 9     Fields:    Translation:AnimalsCells
    33. Chitneni SK, Deroose CM, Fonge H, Gijsbers R, Dyubankova N, Balzarini J, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging. Bioorg Med Chem Lett. 2007 Jun 15; 17(12):3458-62. PMID: 17446073.
      Citations:    Fields:    Translation:HumansCells
    34. Chitneni SK, Deroose CM, Balzarini J, Gijsbers R, Celen SJ, de Groot TJ, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. J Med Chem. 2007 Mar 08; 50(5):1041-9. PMID: 17298046.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    35. Kumar Chitneni S, Govaerts C, Adams E, Van Schepdael A, Hoogmartens J. Identification of impurities in erythromycin by liquid chromatography-mass spectrometric detection. J Chromatogr A. 2004 Nov 12; 1056(1-2):111-20. PMID: 15595540.
      Citations: 2     Fields:    
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