 Integrin alphaVbeta3
"Integrin alphaVbeta3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
| Descriptor ID |
D039302
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| MeSH Number(s) |
D12.776.395.550.625.439 D12.776.543.550.625.439 D12.776.543.750.705.408.460.870.500 D12.776.543.750.705.675.541
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| Concept/Terms |
Integrin alphaVbeta3- Integrin alphaVbeta3
- alphaVbeta3, Integrin
- Integrin alpha-v beta-3
- Integrin alpha v beta 3
- alpha-v beta-3, Integrin
- beta-3, Integrin alpha-v
- alpha-v beta-3 Integrin Receptors
- alpha v beta 3 Integrin Receptors
- Receptors, alpha-v beta-3 Integrin
- Receptors, alpha v beta 3 Integrin
- Vitronectin Receptor
- Receptor, Vitronectin
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Below are MeSH descriptors whose meaning is more general than "Integrin alphaVbeta3".
Below are MeSH descriptors whose meaning is more specific than "Integrin alphaVbeta3".
This graph shows the total number of publications written about "Integrin alphaVbeta3" by people in this website by year, and whether "Integrin alphaVbeta3" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 2 | 3 | 5 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alphaVbeta3" by people in Profiles.
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Barua A, Yellapa A, Bahr JM, Machado SA, Bitterman P, Basu S, Sharma S, Abramowicz JS. Enhancement of ovarian tumor detection with avß3 integrin-targeted ultrasound molecular imaging agent in laying hens: a preclinical model of spontaneous ovarian cancer. Int J Gynecol Cancer. 2014 Jan; 24(1):19-28.
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Traub S, Morgner J, Martino MM, Höning S, Swartz MA, Wickström SA, Hubbell JA, Eming SA. The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165. Biomaterials. 2013 Aug; 34(24):5958-68.
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Moyano JV, Greciano PG, Buschmann MM, Koch M, Matlin KS. Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. Mol Biol Cell. 2010 Nov 01; 21(21):3654-68.
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Kaur S, Kenny HA, Jagadeeswaran S, Zillhardt MR, Montag AG, Kistner E, Yamada SD, Mitra AK, Lengyel E. {beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer. Am J Pathol. 2009 Nov; 175(5):2184-96.
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Hall H, Hubbell JA. Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2. Microvasc Res. 2004 Nov; 68(3):169-78.
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Brown CK, Khodarev NN, Yu J, Moo-Young T, Labay E, Darga TE, Posner MC, Weichselbaum RR, Mauceri HJ. Glioblastoma cells block radiation-induced programmed cell death of endothelial cells. FEBS Lett. 2004 May 07; 565(1-3):167-70.
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Shao R, Bao S, Bai X, Blanchette C, Anderson RM, Dang T, Gishizky ML, Marks JR, Wang XF. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol. 2004 May; 24(9):3992-4003.
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Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang XF. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell. 2004 Apr; 5(4):329-39.
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Hall H, Djonov V, Ehrbar M, Hoechli M, Hubbell JA. Heterophilic interactions between cell adhesion molecule L1 and alphavbeta3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo. Angiogenesis. 2004; 7(3):213-23.
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Richards J, Miller M, Abend J, Koide A, Koide S, Dewhurst S. Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin. J Mol Biol. 2003 Mar 07; 326(5):1475-88.
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