"Integrin alpha5beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
| Descriptor ID |
D039081
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| MeSH Number(s) |
D12.776.395.550.625.379 D12.776.543.550.625.379 D12.776.543.750.705.408.530.750 D12.776.543.750.705.408.850.349 D12.776.543.750.705.675.460 D12.776.543.750.705.876.374
|
| Concept/Terms |
Integrin alpha5beta1- Integrin alpha5beta1
- alpha5beta1, Integrin
- Integrin alpha-5 beta-1
- Integrin alpha 5 beta 1
- alpha-5 beta-1, Integrin
- beta-1, Integrin alpha-5
- Platelet Glycoprotein Ic-IIa
- Glycoprotein Ic-IIa, Platelet
- Ic-IIa, Platelet Glycoprotein
- Platelet Glycoprotein Ic IIa
- VLA-5
- VLA-5 Receptors
- VLA 5 Receptors
- Fibronectin Receptor
- Receptor, Fibronectin
- Receptors, VLA-5
- Receptors, VLA 5
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha5beta1".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha5beta1".
This graph shows the total number of publications written about "Integrin alpha5beta1" by people in this website by year, and whether "Integrin alpha5beta1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin alpha5beta1" by people in Profiles.
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Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. J Cell Biol. 2017 11 06; 216(11):3799-3816.
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Selective regulation of cytoskeletal tension and cell-matrix adhesion by RhoA and Src. Integr Biol (Camb). 2014 Aug; 6(8):743-54.
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Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing. Sci Transl Med. 2011 Sep 14; 3(100):100ra89.
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A phase II, single-arm study of the anti-a5ß1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer. Gynecol Oncol. 2011 May 01; 121(2):273-9.
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Ligand-independent activation of c-Met by fibronectin and a(5)ß(1)-integrin regulates ovarian cancer invasion and metastasis. Oncogene. 2011 Mar 31; 30(13):1566-76.
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Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Biomaterials. 2009 Feb; 30(6):1089-97.
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Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. Cancer Res. 2008 Apr 01; 68(7):2329-39.
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c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res. 2007 Feb 15; 67(4):1670-9.