 Endophenotypes
"Endophenotypes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.
| Descriptor ID |
D058068
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| MeSH Number(s) |
G05.695.224
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Endophenotypes".
Below are MeSH descriptors whose meaning is more specific than "Endophenotypes".
This graph shows the total number of publications written about "Endophenotypes" by people in this website by year, and whether "Endophenotypes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2011 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 2 | 2 | | 2017 | 1 | 1 | 2 | | 2021 | 0 | 2 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Endophenotypes" by people in Profiles.
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Clementz BA, Parker DA, Trotti RL, McDowell JE, Keedy SK, Keshavan MS, Pearlson GD, Gershon ES, Ivleva EI, Huang LY, Hill SK, Sweeney JA, Thomas O, Hudgens-Haney M, Gibbons RD, Tamminga CA. Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium. Schizophr Bull. 2022 01 21; 48(1):56-68.
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Eskridge CLM, Hochberger WC, Kaseda ET, Lencer R, Reilly JL, Keedy SK, Keefe RSE, Pearlson GD, Keshavan MS, Tamminga CA, Sweeney JA, Hill SK. Deficits in generalized cognitive ability, visual sensorimotor function, and inhibitory control represent discrete domains of neurobehavioral deficit in psychotic disorders. Schizophr Res. 2021 10; 236:54-60.
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Gershon ES, Lee SH, Zhou X, Sweeney JA, Tamminga C, Pearlson GA, Clementz BA, Keshavan MS, Alliey-Rodriguez N, Hudgens-Haney M, Keedy SK, Glahn DC, Asif H, Lencer R, Hill SK. An opportunity for primary prevention research in psychotic disorders. Schizophr Res. 2022 May; 243:433-439.
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McShane PJ. A New Bronchiectasis Endophenotype: Immunoallertypes. Am J Respir Crit Care Med. 2019 Apr 01; 199(7):811-812.
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Gray JC, MacKillop J, Weafer J, Hernandez KM, Gao J, Palmer AA, de Wit H. Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation. Psychiatry Res. 2018 01; 259:398-404.
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Chen R, Davis LK, Guter S, Wei Q, Jacob S, Potter MH, Cox NJ, Cook EH, Sutcliffe JS, Li B. Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism. Mol Autism. 2017; 8:14.
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Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP. Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep. 2015 Dec 01; 38(12):1849-60.
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Maranville JC, Cox NJ. Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits. Pharmacogenomics J. 2016 08; 16(4):388-92.
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Odlaug BL, Chamberlain SR, Derbyshire KL, Leppink EW, Grant JE. Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania. J Psychiatr Res. 2014 Dec; 59:167-73.
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Akpudo H, Aleksic B, Alkelai A, Burton C, Carrillo-Roa T, Carillo Roa T, Chen DT, Cheng MC, Cocchi E, Davis LK, Giori IG, Hubbard LM, Merikangas A, Moily NS, Okewole A, Olfson E, Pappa I, Reitt M, Singh AB, Steinberg J, Strohmaier J, Ting TT, van Hulzen KJ, O'Shea A, DeLisi LE. Summaries of oral sessions at the XXI World Congress of Psychiatric Genetics, Boston, Massachusetts, 17-21 October 2013: state of the field. Psychiatr Genet. 2014 Aug; 24(4):125-50.
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