 Endophenotypes
"Endophenotypes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.
| Descriptor ID |
D058068
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| MeSH Number(s) |
G05.695.224
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Endophenotypes".
Below are MeSH descriptors whose meaning is more specific than "Endophenotypes".
This graph shows the total number of publications written about "Endophenotypes" by people in this website by year, and whether "Endophenotypes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 2 | 2 | | 2017 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Endophenotypes" by people in Profiles.
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McShane PJ. A New Bronchiectasis Endophenotype: Immunoallertypes. Am J Respir Crit Care Med. 2019 Apr 01; 199(7):811-812.
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Gray JC, MacKillop J, Weafer J, Hernandez KM, Gao J, Palmer AA, de Wit H. Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation. Psychiatry Res. 2018 01; 259:398-404.
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Chen R, Davis LK, Guter S, Wei Q, Jacob S, Potter MH, Cox NJ, Cook EH, Sutcliffe JS, Li B. Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism. Mol Autism. 2017; 8:14.
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Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP. Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep. 2015 Dec 01; 38(12):1849-60.
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Maranville JC, Cox NJ. Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits. Pharmacogenomics J. 2016 08; 16(4):388-92.
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Odlaug BL, Chamberlain SR, Derbyshire KL, Leppink EW, Grant JE. Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania. J Psychiatr Res. 2014 Dec; 59:167-73.
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Akpudo H, Aleksic B, Alkelai A, Burton C, Carrillo-Roa T, Carillo Roa T, Chen DT, Cheng MC, Cocchi E, Davis LK, Giori IG, Hubbard LM, Merikangas A, Moily NS, Okewole A, Olfson E, Pappa I, Reitt M, Singh AB, Steinberg J, Strohmaier J, Ting TT, van Hulzen KJ, O'Shea A, DeLisi LE. Summaries of oral sessions at the XXI World Congress of Psychiatric Genetics, Boston, Massachusetts, 17-21 October 2013: state of the field. Psychiatr Genet. 2014 Aug; 24(4):125-50.
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Reilly JL, Frankovich K, Hill S, Gershon ES, Keefe RS, Keshavan MS, Pearlson GD, Tamminga CA, Sweeney JA. Elevated antisaccade error rate as an intermediate phenotype for psychosis across diagnostic categories. Schizophr Bull. 2014 Sep; 40(5):1011-21.
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Greenwood TA, Badner JA, Byerley W, Keck PE, McElroy SL, Remick RA, Dessa Sadovnick A, Kelsoe JR. Heritability and linkage analysis of personality in bipolar disorder. J Affect Disord. 2013 Nov; 151(2):748-755.
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Savic D, Distler MG, Sokoloff G, Shanahan NA, Dulawa SC, Palmer AA, Nobrega MA. Modulation ofTcf7l2 expression alters behavior in mice. PLoS One. 2011; 6(10):e26897.
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