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Sudha Chakrapani

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InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, Chakrapani S. Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nat Commun. 2023 03 13; 14(1):1363. PMID: 36914669; PMCID: PMC10011588.
      Citations: 1     Fields:    Translation:Animals
    2. Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S. Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nat Commun. 2022 08 18; 13(1):4862. PMID: 35982060; PMCID: PMC9388682.
      Citations:    Fields:    
    3. Kumar A, Basak S, Chakrapani S. Recombinant expression and purification of pentameric ligand-gated ion channels for Cryo-EM structural studies. Methods Enzymol. 2021; 652:81-103. PMID: 34059291.
      Citations: 2     Fields:    Translation:Cells
    4. Gibbs E, Chakrapani S. Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3. Subcell Biochem. 2021; 96:373-408. PMID: 33252737.
      Citations: 7     Fields:    Translation:Humans
    5. Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, Filizola M, Chakrapani S. High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition. Elife. 2020 10 16; 9. PMID: 33063666; PMCID: PMC7655109.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    6. Kumar A, Basak S, Rao S, Gicheru Y, Mayer ML, Sansom MSP, Chakrapani S. Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs. Nat Commun. 2020 07 27; 11(1):3752. PMID: 32719334; PMCID: PMC7385131.
      Citations: 43     Fields:    Translation:AnimalsCells
    7. Basak S, Gicheru Y, Kapoor A, Mayer ML, Filizola M, Chakrapani S. Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor. Nat Commun. 2019 07 19; 10(1):3225. PMID: 31324772; PMCID: PMC6642186.
      Citations: 18     Fields:    Translation:AnimalsCells
    8. Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S. Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor. Nature. 2018 11; 563(7730):270-274. PMID: 30401837; PMCID: PMC6237196.
      Citations: 52     Fields:    Translation:AnimalsCells
    9. Gicheru Y, Chakrapani S. Direct visualization of ion-channel gating in a native environment. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10198-10200. PMID: 30257939; PMCID: PMC6187156.
      Citations: 2     Fields:    Translation:Cells
    10. Chatterjee S, Vyas R, Chalamalasetti SV, Sahu ID, Wan X, Lorigan GA, Chakrapani S, Clatot J, Deschênes I. The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation. J Gen Physiol. 2018 09 03; 150(9):1333-1347. PMID: 30082431; PMCID: PMC6122925.
      Citations: 12     Fields:    Translation:HumansCells
    11. Basak S, Gicheru Y, Samanta A, Molugu SK, Huang W, Fuente M, Hughes T, Taylor DJ, Nieman MT, Moiseenkova-Bell V, Chakrapani S. Cryo-EM structure of 5-HT3A receptor in its resting conformation. Nat Commun. 2018 02 06; 9(1):514. PMID: 29410406; PMCID: PMC5802770.
      Citations: 42     Fields:    Translation:AnimalsCells
    12. Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nat Struct Mol Biol. 2018 01; 25(1):53-60. PMID: 29323279; PMCID: PMC5951624.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    13. Basak S, Schmandt N, Gicheru Y, Chakrapani S. Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel. Elife. 2017 03 06; 6. PMID: 28262093; PMCID: PMC5378477.
      Citations: 38     Fields:    Translation:Cells
    14. Maiti B, Manna AK, McCleese C, Doane TL, Chakrapani S, Burda C, Dunietz BD. Photoinduced Homolytic Bond Cleavage of the Central Si-C Bond in Porphyrin Macrocycles Is a Charge Polarization Driven Process. J Phys Chem A. 2016 Oct 06; 120(39):7634-7640. PMID: 27654631.
      Citations: 2     Fields:    
    15. Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X. VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nat Commun. 2016 08 26; 7:12646. PMID: 27561680; PMCID: PMC5007466.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    16. Basak S, Chatterjee S, Chakrapani S. Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels. J Vis Exp. 2016 07 04; (113). PMID: 27403967; PMCID: PMC4961264.
      Citations: 3     Fields:    Translation:Cells
    17. Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S. A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation. J Gen Physiol. 2015 Oct; 146(4):323-40. PMID: 26415570; PMCID: PMC4586589.
      Citations: 8     Fields:    Translation:AnimalsCells
    18. Chakrapani S. EPR Studies of Gating Mechanisms in Ion Channels. Methods Enzymol. 2015; 557:279-306. PMID: 25950970; PMCID: PMC4503332.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    19. Huynh KW, Holdaway HA, Stewart PL, Cohen MR, Chakrapani S, Moiseenkova-Bell VY. Structural insight into the assembly of TRPV channels. Structure. 2014 Feb 04; 22(2):260-8. PMID: 24373766; PMCID: PMC5548120.
      Citations: 36     Fields:    Translation:AnimalsCells
    20. Velisetty P, Chalamalasetti SV, Chakrapani S. Structural basis for allosteric coupling at the membrane-protein interface in Gloeobacter violaceus ligand-gated ion channel (GLIC). J Biol Chem. 2014 Jan 31; 289(5):3013-25. PMID: 24338475; PMCID: PMC3908432.
      Citations: 21     Fields:    Translation:Cells
    21. Ostmeyer J, Chakrapani S, Pan AC, Perozo E, Roux B. Recovery from slow inactivation in K+ channels is controlled by water molecules. Nature. 2013 Sep 05; 501(7465):121-4. PMID: 23892782; PMCID: PMC3799803.
      Citations: 83     Fields:    Translation:Cells
    22. Velisetty P, Chalamalasetti SV, Chakrapani S. Conformational transitions underlying pore opening and desensitization in membrane-embedded Gloeobacter violaceus ligand-gated ion channel (GLIC). J Biol Chem. 2012 Oct 26; 287(44):36864-72. PMID: 22977232; PMCID: PMC3481289.
      Citations: 29     Fields:    Translation:Cells
    23. Velisetty P, Chakrapani S. Desensitization mechanism in prokaryotic ligand-gated ion channel. J Biol Chem. 2012 May 25; 287(22):18467-77. PMID: 22474322; PMCID: PMC3365738.
      Citations: 36     Fields:    Translation:Cells
    24. Cordero-Morales JF, Jogini V, Chakrapani S, Perozo E. A multipoint hydrogen-bond network underlying KcsA C-type inactivation. Biophys J. 2011 May 18; 100(10):2387-93. PMID: 21575572; PMCID: PMC3093550.
      Citations: 66     Fields:    Translation:AnimalsCells
    25. Chakrapani S, Cordero-Morales JF, Jogini V, Pan AC, Cortes DM, Perozo E, Roux B. On the structural basis of modal gating behavior in K(+) channels. Nat Struct Mol Biol. 2011 Jan; 18(1):67-74. PMID: 21186363; PMCID: PMC3059741.
      Citations: 49     Fields:    Translation:Cells
    26. Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, Cordero-Morales JF, Chakrapani S, Perozo E, Roux B. Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature. 2010 Jul 08; 466(7303):272-5. PMID: 20613845; PMCID: PMC3033755.
      Citations: 192     Fields:    Translation:HumansCells
    27. Chakrapani S, Sompornpisut P, Intharathep P, Perozo E, Roux B. The activated state of a sodium channel voltage sensor in a membrane environment. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5435-40. PMID: 20207950; PMCID: PMC2851821.
      Citations: 33     Fields:    Translation:Cells
    28. Chakrapani S, Cuello LG, Cortes DM, Perozo E. Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure. 2008 Mar; 16(3):398-409. PMID: 18334215; PMCID: PMC2703488.
      Citations: 66     Fields:    Translation:Cells
    29. Chakrapani S, Cordero-Morales JF, Perozo E. A quantitative description of KcsA gating II: single-channel currents. J Gen Physiol. 2007 Nov; 130(5):479-96. PMID: 17938231; PMCID: PMC2151667.
      Citations: 58     Fields:    Translation:Cells
    30. Chakrapani S, Cordero-Morales JF, Perozo E. A quantitative description of KcsA gating I: macroscopic currents. J Gen Physiol. 2007 Nov; 130(5):465-78. PMID: 17938230; PMCID: PMC2151670.
      Citations: 74     Fields:    Translation:Cells
    31. Chakrapani S, Perozo E. How to gate an ion channel: lessons from MthK. Nat Struct Mol Biol. 2007 Mar; 14(3):180-2. PMID: 17334406.
      Citations: 11     Fields:    Translation:Cells
    32. Chakrapani S, Auerbach A. A speed limit for conformational change of an allosteric membrane protein. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):87-92. PMID: 15618401; PMCID: PMC544059.
      Citations: 51     Fields:    Translation:Cells
    33. Chakrapani S, Bailey TD, Auerbach A. Gating dynamics of the acetylcholine receptor extracellular domain. J Gen Physiol. 2004 Apr; 123(4):341-56. PMID: 15051806; PMCID: PMC2217457.
      Citations: 86     Fields:    Translation:AnimalsCells
    34. Chakrapani S, Bailey TD, Auerbach A. The role of loop 5 in acetylcholine receptor channel gating. J Gen Physiol. 2003 Nov; 122(5):521-39. PMID: 14557402; PMCID: PMC2229574.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
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