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Sudha Chakrapani

AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kumar A, Basak S, Chakrapani S. Recombinant expression and purification of pentameric ligand-gated ion channels for Cryo-EM structural studies. Methods Enzymol. 2021; 652:81-103. PMID: 34059291.
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    2. Gibbs E, Chakrapani S. Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3. Subcell Biochem. 2021; 96:373-408. PMID: 33252737.
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    3. Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, Filizola M, Chakrapani S. High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition. Elife. 2020 10 16; 9. PMID: 33063666.
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    4. Kumar A, Basak S, Rao S, Gicheru Y, Mayer ML, Sansom MSP, Chakrapani S. Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs. Nat Commun. 2020 07 27; 11(1):3752. PMID: 32719334.
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    5. Basak S, Gicheru Y, Kapoor A, Mayer ML, Filizola M, Chakrapani S. Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor. Nat Commun. 2019 07 19; 10(1):3225. PMID: 31324772.
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    6. Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S. Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor. Nature. 2018 11; 563(7730):270-274. PMID: 30401837.
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    7. Gicheru Y, Chakrapani S. Direct visualization of ion-channel gating in a native environment. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10198-10200. PMID: 30257939.
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    8. Chatterjee S, Vyas R, Chalamalasetti SV, Sahu ID, Clatot J, Wan X, Lorigan GA, Deschênes I, Chakrapani S. The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation. J Gen Physiol. 2018 09 03; 150(9):1333-1347. PMID: 30082431.
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    9. Basak S, Gicheru Y, Samanta A, Molugu SK, Huang W, Fuente M, Hughes T, Taylor DJ, Nieman MT, Moiseenkova-Bell V, Chakrapani S. Cryo-EM structure of 5-HT3A receptor in its resting conformation. Nat Commun. 2018 02 06; 9(1):514. PMID: 29410406.
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    10. Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nat Struct Mol Biol. 2018 01; 25(1):53-60. PMID: 29323279.
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    11. Basak S, Schmandt N, Gicheru Y, Chakrapani S. Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel. Elife. 2017 03 06; 6. PMID: 28262093.
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    12. Maiti B, Manna AK, McCleese C, Doane TL, Chakrapani S, Burda C, Dunietz BD. Photoinduced Homolytic Bond Cleavage of the Central Si-C Bond in Porphyrin Macrocycles Is a Charge Polarization Driven Process. J Phys Chem A. 2016 Oct 06; 120(39):7634-7640. PMID: 27654631.
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    13. Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X. VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nat Commun. 2016 08 26; 7:12646. PMID: 27561680.
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    14. Basak S, Chatterjee S, Chakrapani S. Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels. J Vis Exp. 2016 07 04; (113). PMID: 27403967.
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    15. Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S. A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation. J Gen Physiol. 2015 Oct; 146(4):323-40. PMID: 26415570.
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    16. Chakrapani S. EPR Studies of Gating Mechanisms in Ion Channels. Methods Enzymol. 2015; 557:279-306. PMID: 25950970.
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    17. Huynh KW, Cohen MR, Chakrapani S, Holdaway HA, Stewart PL, Moiseenkova-Bell VY. Structural insight into the assembly of TRPV channels. Structure. 2014 Feb 04; 22(2):260-8. PMID: 24373766.
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    18. Velisetty P, Chalamalasetti SV, Chakrapani S. Structural basis for allosteric coupling at the membrane-protein interface in Gloeobacter violaceus ligand-gated ion channel (GLIC). J Biol Chem. 2014 Jan 31; 289(5):3013-25. PMID: 24338475.
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    19. Ostmeyer J, Chakrapani S, Pan AC, Perozo E, Roux B. Recovery from slow inactivation in K+ channels is controlled by water molecules. Nature. 2013 Sep 05; 501(7465):121-4. PMID: 23892782.
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    20. Velisetty P, Chalamalasetti SV, Chakrapani S. Conformational transitions underlying pore opening and desensitization in membrane-embedded Gloeobacter violaceus ligand-gated ion channel (GLIC). J Biol Chem. 2012 Oct 26; 287(44):36864-72. PMID: 22977232.
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    21. Velisetty P, Chakrapani S. Desensitization mechanism in prokaryotic ligand-gated ion channel. J Biol Chem. 2012 May 25; 287(22):18467-77. PMID: 22474322.
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    22. Cordero-Morales JF, Jogini V, Chakrapani S, Perozo E. A multipoint hydrogen-bond network underlying KcsA C-type inactivation. Biophys J. 2011 May 18; 100(10):2387-93. PMID: 21575572.
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    23. Chakrapani S, Cordero-Morales JF, Jogini V, Pan AC, Cortes DM, Roux B, Perozo E. On the structural basis of modal gating behavior in K(+) channels. Nat Struct Mol Biol. 2011 Jan; 18(1):67-74. PMID: 21186363.
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    24. Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, Cordero-Morales JF, Chakrapani S, Roux B, Perozo E. Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature. 2010 Jul 08; 466(7303):272-5. PMID: 20613845.
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    25. Chakrapani S, Sompornpisut P, Intharathep P, Roux B, Perozo E. The activated state of a sodium channel voltage sensor in a membrane environment. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5435-40. PMID: 20207950.
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    26. Chakrapani S, Cuello LG, Cortes DM, Perozo E. Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure. 2008 Mar; 16(3):398-409. PMID: 18334215.
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    27. Chakrapani S, Cordero-Morales JF, Perozo E. A quantitative description of KcsA gating II: single-channel currents. J Gen Physiol. 2007 Nov; 130(5):479-96. PMID: 17938231.
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    28. Chakrapani S, Cordero-Morales JF, Perozo E. A quantitative description of KcsA gating I: macroscopic currents. J Gen Physiol. 2007 Nov; 130(5):465-78. PMID: 17938230.
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    29. Chakrapani S, Perozo E. How to gate an ion channel: lessons from MthK. Nat Struct Mol Biol. 2007 Mar; 14(3):180-2. PMID: 17334406.
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    30. Chakrapani S, Auerbach A. A speed limit for conformational change of an allosteric membrane protein. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):87-92. PMID: 15618401.
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    31. Chakrapani S, Bailey TD, Auerbach A. Gating dynamics of the acetylcholine receptor extracellular domain. J Gen Physiol. 2004 Apr; 123(4):341-56. PMID: 15051806.
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    32. Chakrapani S, Bailey TD, Auerbach A. The role of loop 5 in acetylcholine receptor channel gating. J Gen Physiol. 2003 Nov; 122(5):521-39. PMID: 14557402.
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