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Lin Shen

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Rheumatology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Autoimmune rheumatic diseases, which constitute a broad range of chronic illnesses, cause significant morbidity and mortality in the US and worldwide. T cell antigen receptor (TCR) recognition and signaling have long be recognized to play a critical role in the pathogenesis of autoimmune diseases. However, how altered TCR signaling strength affects immune tolerance and promotes autoimmunity remains incompletely understood. The major goal of Dr. Shen’s laboratory is to understand how abnormal TCR signaling resulting from mutations from human patients with immune dysregulated disorders may alter T cell antigen sensitivity and impair immune tolerance. Studying human monogenic diseases with known genetic defects and autoimmune phenotypes provides us with a unique opportunity for advancing our knowledge of disease pathogenesis of more common polygenic autoimmune diseases. These studies may also have implications in preventing cancer immunotherapy related adverse events and identification of new therapeutic targets for autoimmune diseases.

    Collapse Biography 
    Collapse education and training
    Peking Union Medical CollegeMD
    Johns Hopkins University School of MedicinePhD
    University of Pittsburgh Medical CenterResidency
    University of California, San FranciscoRheumatology Fellowship

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ashouri JF, Lo WL, Nguyen TTT, Shen L, Weiss A. ZAP70, too little, too much can lead to autoimmunity. Immunol Rev. 2022 05; 307(1):145-160. PMID: 34923645; PMCID: PMC8986586.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    2. Nguyen TTT, Wang ZE, Shen L, Schroeder A, Eckalbar W, Weiss A. Cbl-b deficiency prevents functional but not phenotypic T cell anergy. J Exp Med. 2021 07 05; 218(7). PMID: 33974042; PMCID: PMC8117209.
      Citations: 10     Fields:    Translation:AnimalsCells
    3. Shen L, Matloubian M, Kadlecek TA, Weiss A. A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands. Sci Signal. 2021 02 02; 14(668). PMID: 33531381; PMCID: PMC8009134.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    4. Au-Yeung BB, Shah NH, Shen L, Weiss A. ZAP-70 in Signaling, Biology, and Disease. Annu Rev Immunol. 2018 04 26; 36:127-156. PMID: 29237129.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    5. Jilek BL, Zarr M, Sampah ME, Rabi SA, Bullen CK, Lai J, Shen L, Siliciano RF. A quantitative basis for antiretroviral therapy for HIV-1 infection. Nat Med. 2012 Feb 19; 18(3):446-51. PMID: 22344296; PMCID: PMC3296892.
      Citations: 93     Fields:    Translation:HumansCells
    6. Shen L, Rabi SA, Sedaghat AR, Shan L, Lai J, Xing S, Siliciano RF. A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs. Sci Transl Med. 2011 Jul 13; 3(91):91ra63. PMID: 21753122; PMCID: PMC3488347.
      Citations: 32     Fields:    Translation:Cells
    7. Sampah ME, Shen L, Jilek BL, Siliciano RF. Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance. Proc Natl Acad Sci U S A. 2011 May 03; 108(18):7613-8. PMID: 21502494; PMCID: PMC3088572.
      Citations: 49     Fields:    Translation:HumansCells
    8. McMahon MA, Parsons TL, Shen L, Siliciano JD, Siliciano RF. Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses. J Virol. 2011 May; 85(9):4618-22. PMID: 21325417; PMCID: PMC3126274.
      Citations: 10     Fields:    Translation:HumansCells
    9. Bellows ML, Taylor MS, Cole PA, Shen L, Siliciano RF, Fung HK, Floudas CA. Discovery of entry inhibitors for HIV-1 via a new de novo protein design framework. Biophys J. 2010 Nov 17; 99(10):3445-53. PMID: 21081094; PMCID: PMC2980751.
      Citations: 24     Fields:    Translation:HumansCells
    10. Rabi SA, O'Connell KA, Nikolaeva D, Bailey JR, Jilek BL, Shen L, Page KR, Siliciano RF, Blankson JN. Unstimulated primary CD4+ T cells from HIV-1-positive elite suppressors are fully susceptible to HIV-1 entry and productive infection. J Virol. 2011 Jan; 85(2):979-86. PMID: 21068257; PMCID: PMC3020020.
      Citations: 26     Fields:    Translation:HumansCells
    11. Shen L, Siliciano RF. Achieving a quantitative understanding of antiretroviral drug efficacy. Clin Infect Dis. 2010 Nov 01; 51(9):1105-6; author reply 1106-7. PMID: 20925507; PMCID: PMC3963156.
      Citations: 3     Fields:    Translation:Humans
    12. McMahon MA, Shen L, Siliciano RF. New approaches for quantitating the inhibition of HIV-1 replication by antiviral drugs in vitro and in vivo. Curr Opin Infect Dis. 2009 Dec; 22(6):574-82. PMID: 19841584; PMCID: PMC3939826.
      Citations: 17     Fields:    Translation:HumansCells
    13. Shen L, Rabi SA, Siliciano RF. A novel method for determining the inhibitory potential of anti-HIV drugs. Trends Pharmacol Sci. 2009 Dec; 30(12):610-6. PMID: 19837466; PMCID: PMC3385974.
      Citations: 23     Fields:    Translation:HumansCells
    14. Yang HC, Shen L, Siliciano RF, Pomerantz JL. Isolation of a cellular factor that can reactivate latent HIV-1 without T cell activation. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6321-6. PMID: 19336585; PMCID: PMC2663775.
      Citations: 22     Fields:    Translation:HumansCells
    15. Zhou Y, Shen L, Yang HC, Siliciano RF. Preferential cytolysis of peripheral memory CD4+ T cells by in vitro X4-tropic human immunodeficiency virus type 1 infection before the completion of reverse transcription. J Virol. 2008 Sep; 82(18):9154-63. PMID: 18596085; PMCID: PMC2546913.
      Citations: 10     Fields:    Translation:HumansCells
    16. Shen L, Siliciano RF. Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection. J Allergy Clin Immunol. 2008 Jul; 122(1):22-8. PMID: 18602567; PMCID: PMC6812482.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    17. Shen L, Peterson S, Sedaghat AR, McMahon MA, Callender M, Zhang H, Zhou Y, Pitt E, Anderson KS, Acosta EP, Siliciano RF. Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs. Nat Med. 2008 Jul; 14(7):762-6. PMID: 18552857; PMCID: PMC2743464.
      Citations: 176     Fields:    Translation:Humans
    18. Sedaghat AR, Dinoso JB, Shen L, Wilke CO, Siliciano RF. Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4832-7. PMID: 18362342; PMCID: PMC2290747.
      Citations: 58     Fields:    Translation:HumansCells
    19. McMahon MA, Jilek BL, Brennan TP, Shen L, Zhou Y, Wind-Rotolo M, Xing S, Bhat S, Hale B, Hegarty R, Chong CR, Liu JO, Siliciano RF, Thio CL. The HBV drug entecavir - effects on HIV-1 replication and resistance. N Engl J Med. 2007 Jun 21; 356(25):2614-21. PMID: 17582071; PMCID: PMC3069686.
      Citations: 80     Fields:    Translation:HumansCells
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