ZAP-70 Protein-Tyrosine Kinase
"ZAP-70 Protein-Tyrosine Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein tyrosine kinase that is required for T-CELL development and T-CELL ANTIGEN RECEPTOR function.
| Descriptor ID |
D051746
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.900 D12.776.476.950
|
| Concept/Terms |
ZAP-70 Protein-Tyrosine Kinase- ZAP-70 Protein-Tyrosine Kinase
- Protein-Tyrosine Kinase, ZAP-70
- ZAP 70 Protein Tyrosine Kinase
- ZAP-70 Kinase
- Kinase, ZAP-70
- ZAP 70 Kinase
- zeta-Chain Associated Protein Kinase (ZAP-70)
- 70 kDa Zeta-Associated Protein
- 70 kDa Zeta Associated Protein
- ZAP-70 Protein
- ZAP 70 Protein
- Syk-Related Tyrosine Kinase
- Syk Related Tyrosine Kinase
- Tyrosine Kinase, Syk-Related
|
Below are MeSH descriptors whose meaning is more general than "ZAP-70 Protein-Tyrosine Kinase".
Below are MeSH descriptors whose meaning is more specific than "ZAP-70 Protein-Tyrosine Kinase".
This graph shows the total number of publications written about "ZAP-70 Protein-Tyrosine Kinase" by people in this website by year, and whether "ZAP-70 Protein-Tyrosine Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "ZAP-70 Protein-Tyrosine Kinase" by people in Profiles.
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Cbl-b deficiency prevents functional but not phenotypic T cell anergy. J Exp Med. 2021 07 05; 218(7).
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A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands. Sci Signal. 2021 02 02; 14(668).
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ZAP-70 in Signaling, Biology, and Disease. Annu Rev Immunol. 2018 04 26; 36:127-156.
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An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. Elife. 2016 10 04; 5.
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Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemia. Haematologica. 2016 Apr; 101(4):458-65.
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Cytogenetic prioritization with inclusion of molecular markers predicts outcome in previously untreated patients with chronic lymphocytic leukemia treated with fludarabine or fludarabine plus cyclophosphamide: a long-term follow-up study of the US intergroup phase III trial E2997. Leuk Lymphoma. 2015; 56(11):3031-7.
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Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCa subversion induces up-regulation of PKCßII expression in B lymphocytes. Haematologica. 2015 Apr; 100(4):499-510.
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Quantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia. J Clin Oncol. 2012 Jul 10; 30(20):2483-91.
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The impact of ex vivo clinical grade activation protocols on human T-cell phenotype and function for the generation of genetically modified cells for adoptive cell transfer therapy. J Immunother. 2010 Oct; 33(8):759-68.
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Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain. Cell Death Differ. 2010 Mar; 17(3):522-33.