Anthony Kossiakoff to Binding Sites
This is a "connection" page, showing publications Anthony Kossiakoff has written about Binding Sites.
Connection Strength
1.613
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Conformation-specific synthetic intrabodies modulate mTOR signaling with subcellular spatial resolution. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2424679122.
Score: 0.188
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Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface. J Biol Chem. 2005 Jul 08; 280(27):25524-32.
Score: 0.186
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Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM. Structure. 2019 12 03; 27(12):1862-1874.e7.
Score: 0.127
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Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin. J Mol Biol. 2015 Jul 31; 427(15):2532-2547.
Score: 0.094
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Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces. Curr Opin Struct Biol. 2008 Aug; 18(4):499-506.
Score: 0.058
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The 1.38 A crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway. Proteins. 2008 May 01; 71(2):525-33.
Score: 0.057
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The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry. Biochemistry. 2006 Jul 18; 45(28):8488-98.
Score: 0.051
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Crystal structure and site 1 binding energetics of human placental lactogen. J Mol Biol. 2006 May 05; 358(3):773-84.
Score: 0.049
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The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s). Biochemistry. 2005 Jan 11; 44(1):193-201.
Score: 0.046
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The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17078-83.
Score: 0.045
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Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4. Structure. 2024 11 07; 32(11):1936-1951.e5.
Score: 0.045
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The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors. Adv Protein Chem. 2004; 68:147-69.
Score: 0.043
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Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization. Protein Sci. 2003 Sep; 12(9):1960-70.
Score: 0.042
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Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder. Nat Commun. 2023 02 06; 14(1):635.
Score: 0.040
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Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):952-7.
Score: 0.040
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Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites. J Mol Biol. 2002 Feb 15; 316(2):277-89.
Score: 0.037
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High affinity RNase S-peptide variants obtained by phage display have a novel "hot-spot" of binding energy. Biochemistry. 2001 Nov 13; 40(45):13491-500.
Score: 0.037
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Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature. 2021 07; 595(7868):600-605.
Score: 0.036
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Structural basis of omega-3 fatty acid transport across the blood-brain barrier. Nature. 2021 07; 595(7866):315-319.
Score: 0.036
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Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor. Nat Struct Biol. 2000 Sep; 7(9):808-15.
Score: 0.034
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Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9095-E9104.
Score: 0.029
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Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature. 2018 06; 558(7711):553-558.
Score: 0.029
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Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci. 1997 Sep; 6(9):1806-24.
Score: 0.027
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The X-ray structure of a growth hormone-prolactin receptor complex. Nature. 1994 Dec 01; 372(6505):478-81.
Score: 0.023
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Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors. Protein Sci. 1994 Oct; 3(10):1697-705.
Score: 0.022
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Molecular recognition in biological systems: from activation to inhibition. Biochem Soc Trans. 1993 Aug; 21 ( Pt 3)(3):614-8.
Score: 0.021
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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science. 1992 Jan 17; 255(5042):306-12.
Score: 0.019
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Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution. Biochemistry. 1992 Jan 14; 31(1):270-9.
Score: 0.019
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Neutron structure of subtilisin BPN': effects of chemical environment on hydrogen-bonding geometries and the pattern of hydrogen-deuterium exchange in secondary structure elements. Biochemistry. 1991 Feb 05; 30(5):1211-21.
Score: 0.017
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A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol. 2011 Jan; 18(1):100-6.
Score: 0.017
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Characterization of engineered actin binding proteins that control filament assembly and structure. PLoS One. 2010 Nov 12; 5(11):e13960.
Score: 0.017
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Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J Mol Biol. 2007 Nov 02; 373(4):941-53.
Score: 0.014
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Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis. Protein Sci. 2005 Sep; 14(9):2405-13.
Score: 0.012
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Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis. J Mol Biol. 2005 Apr 01; 347(3):489-94.
Score: 0.012
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The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity. J Mol Biol. 2003 Sep 05; 332(1):195-204.
Score: 0.010
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Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones. Mol Biol Evol. 2002 Jul; 19(7):1083-92.
Score: 0.010
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Neutron diffraction identifies His 57 as the catalytic base in trypsin. Nature. 1980 Nov 27; 288(5789):414-6.
Score: 0.009
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Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis. Biochemistry. 2000 Apr 04; 39(13):3575-84.
Score: 0.008
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Structure of bovine trypsinogen at 1.9 A resolution. Biochemistry. 1977 Feb 22; 16(4):654-64.
Score: 0.007
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Mechanisms of zymogen activation. Annu Rev Biophys Bioeng. 1977; 6:177-93.
Score: 0.002