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Guido Franzoso

AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Capece D, D'Andrea D, Begalli F, Goracci L, Tornatore L, Alexander JL, Di Veroli A, Leow SC, Vaiyapuri TS, Ellis JK, Verzella D, Bennett J, Savino L, Ma Y, McKenzie JS, Doria ML, Mason SE, Chng KR, Keun HC, Frost G, Tergaonkar V, Broniowska K, Stunkel W, Takats Z, Kinross JM, Cruciani G, Franzoso G. Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma. J Clin Invest. 2021 Jun 01; 131(11). PMID: 33878036.
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    2. Saavedra-García P, Roman-Trufero M, Al-Sadah HA, Blighe K, López-Jiménez E, Christoforou M, Penfold L, Capece D, Xiong X, Miao Y, Parzych K, Caputo VS, Siskos AP, Encheva V, Liu Z, Thiel D, Kaiser MF, Piazza P, Chaidos A, Karadimitris A, Franzoso G, Snijders AP, Keun HC, Oyarzún DA, Barahona M, Auner HW. Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs. Proc Natl Acad Sci U S A. 2021 Apr 27; 118(17). PMID: 33883278.
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    3. Vecchiotti D, Verzella D, Capece D, Cornice J, Nolfi MDV, Di Francesco B, Franzoso G, Alesse E, Zazzeroni F. Immunohistochemical Analysis of Expression, Phosphorylation, and Nuclear Translocation of NF-?B Proteins in Human Tissues. Methods Mol Biol. 2021; 2366:27-42. PMID: 34236631.
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    4. Capece D, Verzella D, Begalli F, Bennett J, D'Andrea D, Vecchiotti D, Zazzeroni F, Franzoso G. Extracellular Flux Analysis to Investigate the Impact of NF-?B on Mitochondrial Respiration in Colorectal Carcinoma (CRC). Methods Mol Biol. 2021; 2366:293-303. PMID: 34236646.
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    5. Vecchiotti D, Verzella D, Capece D, Nolfi MDV, Di Francesco B, Cornice J, Franzoso G, Alesse E, Zazzeroni F. Biochemical Methods to Analyze the Subcellular Localization of NF-?B Proteins Using Cell Fractionation. Methods Mol Biol. 2021; 2366:19-25. PMID: 34236630.
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    6. Tornatore L, Capece D, Sandomenico A, Verzella D, Vecchiotti D, Zazzeroni F, Ruvo M, Franzoso G. The Screening of Combinatorial Peptide Libraries for Targeting Key Molecules or Protein-Protein Interactions in the NF-?B Pathway. Methods Mol Biol. 2021; 2366:343-356. PMID: 34236649.
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    7. Sandomenico A, Di Rienzo L, Calvanese L, Iaccarino E, D'Auria G, Falcigno L, Chambery A, Russo R, Franzoso G, Tornatore L, D'Abramo M, Ruvo M, Milanetti E, Raimondo D. Insights into the Interaction Mechanism of DTP3 with MKK7 by Using STD-NMR and Computational Approaches. Biomedicines. 2020 Dec 30; 9(1). PMID: 33396582.
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    8. Verzella D, Pescatore A, Capece D, Vecchiotti D, Ursini MV, Franzoso G, Alesse E, Zazzeroni F. Life, death, and autophagy in cancer: NF-?B turns up everywhere. Cell Death Dis. 2020 03 30; 11(3):210. PMID: 32231206.
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    9. Rajpoot S, Bennett J, Franzoso G, Verzella D, Begalli F, Capece D, D'Andrea D. Reprogramming immunosuppressive tumour-associated dendritic cells with GADD45ß inhibitors. Clin Med (Lond). 2020 03; 20(Suppl 2):s116. PMID: 32409418.
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    10. Capece D, Verzella D, Di Francesco B, Alesse E, Franzoso G, Zazzeroni F. NF-?B and mitochondria cross paths in cancer: mitochondrial metabolism and beyond. Semin Cell Dev Biol. 2020 02; 98:118-128. PMID: 31132468.
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    11. Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-Obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G. Preclinical toxicology and safety pharmacology of the first-in-class GADD45ß/MKK7 inhibitor and clinical candidate, DTP3. Toxicol Rep. 2019; 6:369-379. PMID: 31080744.
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    12. Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-Obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G. Clinical proof of concept for a safe and effective NF-?B-targeting strategy in multiple myeloma. Br J Haematol. 2019 05; 185(3):588-592. PMID: 30255568.
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    13. Rega C, Russo R, Focà A, Sandomenico A, Iaccarino E, Raimondo D, Milanetti E, Tornatore L, Franzoso G, Pedone PV, Ruvo M, Chambery A. Probing the interaction interface of the GADD45ß/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry. Int J Biol Macromol. 2018 Jul 15; 114:114-123. PMID: 29572137.
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    14. Capece D, D'Andrea D, Verzella D, Tornatore L, Begalli F, Bennett J, Zazzeroni F, Franzoso G. Turning an old GADDget into a troublemaker. Cell Death Differ. 2018 03; 25(4):642-644. PMID: 29511335.
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    15. Verzella D, Bennett J, Fischietti M, Thotakura AK, Recordati C, Pasqualini F, Capece D, Vecchiotti D, D'Andrea D, Di Francesco B, De Maglie M, Begalli F, Tornatore L, Papa S, Lawrence T, Forbes SJ, Sica A, Alesse E, Zazzeroni F, Franzoso G. GADD45ß Loss Ablates Innate Immunosuppression in Cancer. Cancer Res. 2018 03 01; 78(5):1275-1292. PMID: 29279355.
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    16. Bennett J, Capece D, Begalli F, Verzella D, D'Andrea D, Tornatore L, Franzoso G. NF-?B in the crosshairs: Rethinking an old riddle. Int J Biochem Cell Biol. 2018 02; 95:108-112. PMID: 29277662.
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    17. Begalli F, Bennett J, Capece D, Verzella D, D'Andrea D, Tornatore L, Franzoso G. Unlocking the NF-?B Conundrum: Embracing Complexity to Achieve Specificity. Biomedicines. 2017 Aug 22; 5(3). PMID: 28829404.
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    18. Koh CM, Khattar E, Leow SC, Liu CY, Muller J, Ang WX, Li Y, Franzoso G, Li S, Guccione E, Tergaonkar V. Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest. 2015 May; 125(5):2109-22. PMID: 25893605.
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    19. Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G. Cancer-Selective Targeting of the NF-?B Survival Pathway with GADD45ß/MKK7 Inhibitors. Cancer Cell. 2014 Dec 08; 26(6):938. PMID: 28898681.
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    20. Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G. Cancer-selective targeting of the NF-?B survival pathway with GADD45ß/MKK7 inhibitors. Cancer Cell. 2014 Oct 13; 26(4):495-508. PMID: 25314077.
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    21. Ling GS, Bennett J, Woollard KJ, Szajna M, Fossati-Jimack L, Taylor PR, Scott D, Franzoso G, Cook HT, Botto M. Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages. Nat Commun. 2014; 5:3039. PMID: 24423728.
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    22. Dall'Ara E, Karl C, Mazza G, Franzoso G, Vena P, Pretterklieber M, Pahr D, Zysset P. Tissue properties of the human vertebral body sub-structures evaluated by means of microindentation. J Mech Behav Biomed Mater. 2013 Sep; 25:23-32. PMID: 23726926.
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    23. Barbarulo A, Iansante V, Chaidos A, Naresh K, Rahemtulla A, Franzoso G, Karadimitris A, Haskard DO, Papa S, Bubici C. Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma. Oncogene. 2013 Sep 05; 32(36):4231-42. PMID: 23045269.
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    24. Tornatore L, Thotakura AK, Bennett J, Moretti M, Franzoso G. The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation. Trends Cell Biol. 2012 Nov; 22(11):557-66. PMID: 22995730.
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    25. Moretti M, Bennett J, Tornatore L, Thotakura AK, Franzoso G. Cancer: NF-?B regulates energy metabolism. Int J Biochem Cell Biol. 2012 Dec; 44(12):2238-43. PMID: 22903018.
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    26. Luo Y, Boyle DL, Hammaker D, Edgar M, Franzoso G, Firestein GS. Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45ß-deficient mice. Arthritis Rheum. 2011 Oct; 63(10):2949-55. PMID: 21702006.
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    27. Mauro C, Leow SC, Anso E, Rocha S, Thotakura AK, Tornatore L, Moretti M, De Smaele E, Beg AA, Tergaonkar V, Chandel NS, Franzoso G. NF-?B controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nat Cell Biol. 2011 Aug 28; 13(10):1272-9. PMID: 21968997.
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    28. Ma L, Mauro C, Cornish GH, Chai JG, Coe D, Fu H, Patton D, Okkenhaug K, Franzoso G, Dyson J, Nourshargh S, Marelli-Berg FM. Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19461-6. PMID: 20978210.
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    29. Yang H, Rivera Z, Jube S, Nasu M, Bertino P, Goparaju C, Franzoso G, Lotze MT, Krausz T, Pass HI, Bianchi ME, Carbone M. Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12611-6. PMID: 20616036.
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    30. Svensson CI, Inoue T, Hammaker D, Fukushima A, Papa S, Franzoso G, Schett G, Corr M, Boyle DL, Firestein GS. Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling. Arthritis Rheum. 2009 Nov; 60(11):3229-40. PMID: 19877043.
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    31. Papa S, Bubici C, Zazzeroni F, Franzoso G. Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways. Biol Chem. 2009 Oct; 390(10):965-76. PMID: 19642868.
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    32. Gilmore TD, Perkins ND, Franzoso G. Getting away from it all in Capri: the 2008 EMBO workshop on NF-kappaB. Cell Death Differ. 2009 Apr; 16(4):651-4. PMID: 19287453.
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    33. Tornatore L, Montil SM, Marasco D, Dathan N, Vitale RM, Benedetti E, Pedone C, Papa S, Franzoso G, Ruvo M. Gadd45beta dimerization does not affect MKK7 binding. Adv Exp Med Biol. 2009; 611:367-8. PMID: 19400229.
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    34. Mauro C, Zazzeroni F, Papa S, Bubici C, Franzoso G. The NF-kappaB transcription factor pathway as a therapeutic target in cancer: methods for detection of NF-kappaB activity. Methods Mol Biol. 2009; 512:169-207. PMID: 19347278.
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    35. Liu B, Suyeoka G, Papa S, Franzoso G, Neufeld AH. Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries. Neurobiol Dis. 2009 Jan; 33(1):104-10. PMID: 18977442.
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    36. Boccaccio A, Vena P, Gastaldi D, Franzoso G, Pietrabissa R, Pappalettere C. Finite element analysis of cancellous bone failure in the vertebral body of healthy and osteoporotic subjects. Proc Inst Mech Eng H. 2008 Oct; 222(7):1023-36. PMID: 19024151.
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    37. Tumanov AV, Koroleva EP, Christiansen PA, Khan MA, Ruddy MJ, Burnette B, Papa S, Franzoso G, Nedospasov SA, Fu YX, Anders RA. T cell-derived lymphotoxin regulates liver regeneration. Gastroenterology. 2009 Feb; 136(2):694-704.e4. PMID: 18952083.
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    38. Papa S, Zazzeroni F, Fu YX, Bubici C, Alvarez K, Dean K, Christiansen PA, Anders RA, Franzoso G. Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling. J Clin Invest. 2008 May; 118(5):1911-23. PMID: 18382767.
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    39. Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM. Gadd45 beta forms a homodimeric complex that binds tightly to MKK7. J Mol Biol. 2008 Apr 18; 378(1):97-111. PMID: 18343408.
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    40. Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G. Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2. J Biol Chem. 2007 Jun 29; 282(26):19029-41. PMID: 17485467.
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    41. Pham CG, Bubici C, Zazzeroni F, Knabb JR, Papa S, Kuntzen C, Franzoso G. Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs. Mol Cell Biol. 2007 Jun; 27(11):3920-35. PMID: 17403902.
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    42. Kuntzen C, Zazzeroni F, Pham CG, Papa S, Bubici C, Knabb JR, Franzoso G. A method for isolating prosurvival targets of NF-kappaB/Rel transcription factors. Methods Mol Biol. 2007; 399:99-124. PMID: 18309928.
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    43. Bubici C, Papa S, Dean K, Franzoso G. Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Oncogene. 2006 Oct 30; 25(51):6731-48. PMID: 17072325.
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    44. Centeno C, Repici M, Chatton JY, Riederer BM, Bonny C, Nicod P, Price M, Clarke PG, Papa S, Franzoso G, Borsello T. Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons. Cell Death Differ. 2007 Feb; 14(2):240-53. PMID: 16794604.
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    45. Yang H, Bocchetta M, Kroczynska B, Elmishad AG, Chen Y, Liu Z, Bubici C, Mossman BT, Pass HI, Testa JR, Franzoso G, Carbone M. TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10397-10402. PMID: 16798876.
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    46. Papa S, Bubici C, Zazzeroni F, Pham CG, Kuntzen C, Knabb JR, Dean K, Franzoso G. The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ. 2006 May; 13(5):712-29. PMID: 16456579.
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    47. Larsen CM, Døssing MG, Papa S, Franzoso G, Billestrup N, Mandrup-Poulsen T. Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells. Diabetologia. 2006 May; 49(5):980-9. PMID: 16528573.
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    48. Mittal A, Papa S, Franzoso G, Sen R. NF-kappaB-dependent regulation of the timing of activation-induced cell death of T lymphocytes. J Immunol. 2006 Feb 15; 176(4):2183-9. PMID: 16455974.
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    49. Bubici C, Papa S, Pham CG, Zazzeroni F, Franzoso G. The NF-kappaB-mediated control of ROS and JNK signaling. Histol Histopathol. 2006 01; 21(1):69-80. PMID: 16267788.
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    50. Pham CG, Papa S, Bubici C, Zazzeroni F, Franzoso G. In the Crosshairs: NF-?B Targets the JNK Signaling Cascade. Curr Med Chem Anti Inflamm Anti Allergy Agents. 2005 Dec 01; 4(6):569-576. PMID: 19829748.
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    51. Papa S, Bubici C, Pham CG, Zazzeroni F, Franzoso G. NF-kappaB meets ROS: an 'iron-ic' encounter. Cell Death Differ. 2005 Oct; 12(10):1259-62. PMID: 15947786.
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    52. Lo JC, Basak S, James ES, Quiambo RS, Kinsella MC, Alegre ML, Weih F, Franzoso G, Hoffmann A, Fu YX. Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues. Blood. 2006 Feb 01; 107(3):1048-55. PMID: 16195333.
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    53. Pham CG, Papa S, Bubici C, Zazzeroni F, Franzoso G. Oxygen JNKies: phosphatases overdose on ROS. Dev Cell. 2005 Apr; 8(4):452-4. PMID: 15809025.
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    54. Bubici C, Papa S, Pham CG, Zazzeroni F, Franzoso G. NF-kappaB and JNK: an intricate affair. . 2004 Dec; 3(12):1524-9. PMID: 15611622.
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    55. Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, Jayawardena S, De Smaele E, Cong R, Beaumont C, Torti FM, Torti SV, Franzoso G. Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell. 2004 Nov 12; 119(4):529-42. PMID: 15537542.
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    56. Papa S, Zazzeroni F, Pham CG, Bubici C, Franzoso G. Linking JNK signaling to NF-kappaB: a key to survival. J Cell Sci. 2004 Oct 15; 117(Pt 22):5197-208. PMID: 15483317.
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    57. Barnhart BC, Legembre P, Pietras E, Bubici C, Franzoso G, Peter ME. CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells. EMBO J. 2004 Aug 04; 23(15):3175-85. PMID: 15272306.
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    58. Papa S, Zazzeroni F, Bubici C, Jayawardena S, Alvarez K, Matsuda S, Nguyen DU, Pham CG, Nelsbach AH, Melis T, De Smaele E, Tang WJ, D'Adamio L, Franzoso G. Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. Nat Cell Biol. 2004 Feb; 6(2):146-53. PMID: 14743220.
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    59. Lo JC, Chin RK, Lee Y, Kang HS, Wang Y, Weinstock JV, Banks T, Ware CF, Franzoso G, Fu YX. Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J Clin Invest. 2003 Nov; 112(10):1495-505. PMID: 14617751.
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    60. Liu N, Raja SM, Zazzeroni F, Metkar SS, Shah R, Zhang M, Wang Y, Brömme D, Russin WA, Lee JC, Peter ME, Froelich CJ, Franzoso G, Ashton-Rickardt PG. NF-kappaB protects from the lysosomal pathway of cell death. EMBO J. 2003 Oct 01; 22(19):5313-22. PMID: 14517268.
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    61. Zazzeroni F, Papa S, Algeciras-Schimnich A, Alvarez K, Melis T, Bubici C, Majewski N, Hay N, De Smaele E, Peter ME, Franzoso G. Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. Blood. 2003 Nov 01; 102(9):3270-9. PMID: 12855571.
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    62. Medici MA, Sciortino MT, Perri D, Amici C, Avitabile E, Ciotti M, Balestrieri E, De Smaele E, Franzoso G, Mastino A. Protection by herpes simplex virus glycoprotein D against Fas-mediated apoptosis: role of nuclear factor kappaB. J Biol Chem. 2003 Sep 19; 278(38):36059-67. PMID: 12844494.
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    63. Franzoso G, Zazzeroni F, Papa S. JNK: a killer on a transcriptional leash. Cell Death Differ. 2003 Jan; 10(1):13-5. PMID: 12655290.
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    64. Jin R, De Smaele E, Zazzeroni F, Nguyen DU, Papa S, Jones J, Cox C, Gelinas C, Franzoso G. Regulation of the gadd45beta promoter by NF-kappaB. DNA Cell Biol. 2002 Jul; 21(7):491-503. PMID: 12162804.
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    65. Guiet C, Silvestri E, De Smaele E, Franzoso G, Vito P. c-FLIP efficiently rescues TRAF-2-/- cells from TNF-induced apoptosis. Cell Death Differ. 2002 Feb; 9(2):138-44. PMID: 11840164.
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    66. De Smaele E, Zazzeroni F, Papa S, Nguyen DU, Jin R, Jones J, Cong R, Franzoso G. Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. Nature. 2001 Nov 15; 414(6861):308-13. PMID: 11713530.
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    67. Leonardi A, Ellinger-Ziegelbauer H, Franzoso G, Brown K, Siebenlist U. Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2. J Biol Chem. 2000 Jan 07; 275(1):271-8. PMID: 10617615.
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    68. Boyce BF, Xing L, Franzoso G, Siebenlist U. Required and nonessential functions of nuclear factor-kappa B in bone cells. Bone. 1999 Jul; 25(1):137-9. PMID: 10423039.
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    69. St Louis DC, Woodcock JB, Franzoso G, Blair PJ, Carlson LM, Murillo M, Wells MR, Williams AJ, Smoot DS, Kaushal S, Grimes JL, Harlan DM, Chute JP, June CH, Siebenlist U, Lee KP, Fransozo G. Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model. J Immunol. 1999 Mar 15; 162(6):3237-48. PMID: 10092775.
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    70. Chariot A, Princen F, Gielen J, Merville MP, Franzoso G, Brown K, Siebenlist U, Bours V. IkappaB-alpha enhances transactivation by the HOXB7 homeodomain-containing protein. J Biol Chem. 1999 Feb 26; 274(9):5318-25. PMID: 10026139.
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    71. Franzoso G, Carlson L, Poljak L, Shores EW, Epstein S, Leonardi A, Grinberg A, Tran T, Scharton-Kersten T, Anver M, Love P, Brown K, Siebenlist U. Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J Exp Med. 1998 Jan 19; 187(2):147-59. PMID: 9432973.
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    72. Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, Leonardi A, Tran T, Boyce BF, Siebenlist U. Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev. 1997 Dec 15; 11(24):3482-96. PMID: 9407039.
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    73. Brown K, Franzoso G, Baldi L, Carlson L, Mills L, Lin YC, Gerstberger S, Siebenlist U. The signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains. Mol Cell Biol. 1997 Jun; 17(6):3021-7. PMID: 9154800.
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    74. Franzoso G, Carlson L, Scharton-Kersten T, Shores EW, Epstein S, Grinberg A, Tran T, Shacter E, Leonardi A, Anver M, Love P, Sher A, Siebenlist U. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Immunity. 1997 Apr; 6(4):479-90. PMID: 9133427.
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    75. Ruocco MR, Chen X, Ambrosino C, Dragonetti E, Liu W, Mallardo M, De Falco G, Palmieri C, Franzoso G, Quinto I, Venuta S, Scala G. Regulation of HIV-1 long terminal repeats by interaction of C/EBP(NF-IL6) and NF-kappaB/Rel transcription factors. J Biol Chem. 1996 Sep 13; 271(37):22479-86. PMID: 8798413.
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    76. Franzoso G, Carlson L, Brown K, Daucher MB, Bressler P, Siebenlist U. Activation of the serum response factor by p65/NF-kappaB. EMBO J. 1996 Jul 01; 15(13):3403-12. PMID: 8670842.
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    77. Baldi L, Brown K, Franzoso G, Siebenlist U. Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha. J Biol Chem. 1996 Jan 05; 271(1):376-9. PMID: 8550590.
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    78. Drew PD, Franzoso G, Carlson LM, Biddison WE, Siebenlist U, Ozato K. Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells. J Neuroimmunol. 1995 Dec 31; 63(2):157-62. PMID: 8550813.
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    79. Drew PD, Franzoso G, Becker KG, Bours V, Carlson LM, Siebenlist U, Ozato K. NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression. J Interferon Cytokine Res. 1995 Dec; 15(12):1037-45. PMID: 8746784.
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    80. Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation. Science. 1995 Mar 10; 267(5203):1485-8. PMID: 7878466.
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    81. Kanno T, Franzoso G, Siebenlist U. Human T-cell leukemia virus type I Tax-protein-mediated activation of NF-kappa B from p100 (NF-kappa B2)-inhibited cytoplasmic reservoirs. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12634-8. PMID: 7809091.
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    82. Kanno T, Brown K, Franzoso G, Siebenlist U. Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B. Mol Cell Biol. 1994 Oct; 14(10):6443-51. PMID: 7935369.
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    83. Franzoso G, Biswas P, Poli G, Carlson LM, Brown KD, Tomita-Yamaguchi M, Fauci AS, Siebenlist UK. A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells. J Exp Med. 1994 Oct 01; 180(4):1445-56. PMID: 7931077.
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    84. Franzoso G, Hu PC, Meloni GA, Barile MF. Immunoblot analyses of chimpanzee sera after infection and after immunization and challenge with Mycoplasma pneumoniae. Infect Immun. 1994 Mar; 62(3):1008-14. PMID: 8112834.
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    85. Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol. 1994; 10:405-55. PMID: 7888182.
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    86. Franzoso G, Bours V, Azarenko V, Park S, Tomita-Yamaguchi M, Kanno T, Brown K, Siebenlist U. The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites. EMBO J. 1993 Oct; 12(10):3893-901. PMID: 8404857.
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    87. Segars JH, Nagata T, Bours V, Medin JA, Franzoso G, Blanco JC, Drew PD, Becker KG, An J, Tang T, et al. Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers. Mol Cell Biol. 1993 Oct; 13(10):6157-69. PMID: 8413217.
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    88. Dimitrov DS, Franzoso G, Salman M, Blumenthal R, Tarshis M, Barile MF, Rottem S. Mycoplasma fermentans (incognitus strain) cells are able to fuse with T lymphocytes. Clin Infect Dis. 1993 Aug; 17 Suppl 1:S305-8. PMID: 8399933.
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    89. Franzoso G, Hu PC, Meloni GA, Barile MF. The immunodominant 90-kilodalton protein is localized on the terminal tip structure of Mycoplasma pneumoniae. Infect Immun. 1993 Apr; 61(4):1523-30. PMID: 8454358.
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    90. Brown K, Park S, Kanno T, Franzoso G, Siebenlist U. Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2532-6. PMID: 8460169.
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    91. Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell. 1993 Mar 12; 72(5):729-39. PMID: 8453667.
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    92. Franzoso G, Bours V, Park S, Tomita-Yamaguchi M, Kelly K, Siebenlist U. The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition. Nature. 1992 Sep 24; 359(6393):339-42. PMID: 1406939.
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    93. Franzoso G, Dimitrov DS, Blumenthal R, Barile MF, Rottem S. Fusion of Mycoplasma fermentans strain incognitus with T-lymphocytes. FEBS Lett. 1992 Jun 01; 303(2-3):251-4. PMID: 1607025.
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    94. Bours V, Franzoso G, Brown K, Park S, Azarenko V, Tomita-Yamaguchi M, Kelly K, Siebenlist U. Lymphocyte activation and the family of NF-kappa B transcription factor complexes. Curr Top Microbiol Immunol. 1992; 182:411-20. PMID: 1490379.
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    95. Franzoso G, Cusinato R, Tonin EA, Meloni GA. [Action of ++clarithromycin against mycoplasma and chlamydia]. G Ital Chemioter. 1991 Jan-Dec; 38(1-3):159-61. PMID: 1365578.
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