"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Descriptor ID |
D017209
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MeSH Number(s) |
G04.146.160
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Concept/Terms |
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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1994 | 4 | 3 | 7 |
1995 | 5 | 1 | 6 |
1996 | 13 | 4 | 17 |
1997 | 22 | 8 | 30 |
1998 | 26 | 15 | 41 |
1999 | 23 | 10 | 33 |
2000 | 25 | 23 | 48 |
2001 | 37 | 22 | 59 |
2002 | 34 | 29 | 63 |
2003 | 45 | 31 | 76 |
2004 | 38 | 48 | 86 |
2005 | 25 | 25 | 50 |
2006 | 22 | 44 | 66 |
2007 | 22 | 33 | 55 |
2008 | 18 | 32 | 50 |
2009 | 13 | 38 | 51 |
2010 | 12 | 45 | 57 |
2011 | 13 | 33 | 46 |
2012 | 18 | 38 | 56 |
2013 | 14 | 41 | 55 |
2014 | 14 | 44 | 58 |
2015 | 12 | 31 | 43 |
2016 | 8 | 39 | 47 |
2017 | 4 | 23 | 27 |
2018 | 12 | 28 | 40 |
2019 | 4 | 13 | 17 |
2020 | 3 | 17 | 20 |
2021 | 1 | 24 | 25 |
2022 | 2 | 4 | 6 |
2023 | 0 | 8 | 8 |
2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Apoptosis" by people in Profiles.
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The potent paracrine effect of umbilical cord mesenchymal stem cells mediates mitochondrial quality control to restore chemotherapy-induced damage in ovarian granulosa cells. Biomed Pharmacother. 2024 Mar; 172:116263.
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Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy. ACS Nano. 2024 Feb 13; 18(6):5152-5166.
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Effect of antibiotic monensin on cell proliferation and IGF1R signaling pathway in human colorectal cancer cells. Ann Med. 2023 12; 55(1):954-964.
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A novel triptolide analog downregulates NF-?B and induces mitochondrial apoptosis pathways in human pancreatic cancer. Elife. 2023 Oct 25; 12.
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Apoptosis in mesenchymal stromal cells activates an immunosuppressive secretome predicting clinical response in Crohn's disease. Mol Ther. 2023 Dec 06; 31(12):3531-3544.
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Targeted Polymersome Delivery of a Stapled Peptide for Drugging the Tumor Protein p53:BCL-2-Family Axis in Diffuse Large B-Cell Lymphoma. ACS Nano. 2023 Dec 12; 17(23):23374-23390.
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Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia. Clin Cancer Res. 2023 08 15; 29(16):3151-3161.
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Method for estimation of apoptotic cell fraction of cytotherapy using in vivo fluorine-19 magnetic resonance: pilot study in a patient with head and neck carcinoma receiving tumor-infiltrating lymphocytes labeled with perfluorocarbon nanoemulsion. J Immunother Cancer. 2023 06; 11(6).
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Innate Conformational Dynamics Drive Binding Specificity in Anti-Apoptotic Proteins Mcl-1 and Bcl-2. Biochemistry. 2023 06 06; 62(11):1619-1630.
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Histotripsy induces apoptosis and reduces hypoxia in a neuroblastoma xenograft model. Int J Hyperthermia. 2023; 40(1):2222941.