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Victoria E. Prince

TitleProfessor
InstitutionUniversity of Chicago
DepartmentOrganismal Biology and Anatomy
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    My research program at the University of Chicago focuses on vertebrate axial regionalization during development using the zebrafish as a model. My group takes a variety of molecular, cellular and genetic approaches to these studies, and we have made important contributions to a variety of research areas, including the understanding of Hox gene regulation of hindbrain patterning, evolution of duplicated genes and genomes in the vertebrates, and patterning of endoderm-derived tissues. Active areas of research in my lab include continuing studies of hindbrain patterning, with an emphasis on understanding neuronal and neural crest migration.


    Collapse Biography 
    Collapse education and training
    Imperial College, London University, LondonBS06/1986Biochemistry
    University College, London University, LondonPhD01/1991Molecular Biology
    University of London, Guy's Hospital, LondonPostdoc06/1994Developmental Neuro
    Princeton University, Princeton, NJPostdoc07/1997Developmental Bio
    Collapse awards and honors
    2015 - 2024Marshal of the University, The University of Chicago
    2016 - 2016Faculty Leadership Award in Program Innovation, University of Chicago
    2010 - 2011Academic Leadership Fellowship, CIC/University of Chicago
    2006 - 2006J &J Neubauer Faculty Development Fellowship in recognition of teaching excellence in the College, University of Chicago
    2005 - 2005The Christianna Smith Lecturer, Mount Holyoke College
    2005 - 2010Faculty of 1000
    1995 - 1997Human Frontiers Science Program Fellowship, Princeton University
    1994 - 1995EMBO Long-Term Fellowship, Princeton University
    1992 - 1994Medical Research Council (UK) Training Fellowship

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Alhashem Z, Feldner-Busztin D, Revell C, Alvarez-Garcillan Portillo M, Camargo-Sosa K, Richardson J, Rocha M, Gauert A, Corbeaux T, Milanetto M, Argenton F, Tiso N, Kelsh R, Prince VE, Bentley K, Linker C. Notch controls the cell cycle to define leader versus follower identities during collective cell migration. Elife. 2022 Apr 19; 11. PMID: 35438077.
      View in: PubMed
    2. Rocha M, Kushkowski E, Schnirman R, Booth C, Singh N, Beadell A, Prince VE. Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body. Dev Biol. 2021 12; 480:25-38. PMID: 34389276.
      View in: PubMed
    3. Dalgin G, Prince VE. Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b. Dev Biol. 2021 03; 471:1-9. PMID: 33290819.
      View in: PubMed
    4. Rocha M, Beiriger A, Kushkowski EE, Miyashita T, Singh N, Venkataraman V, Prince VE. From head to tail: regionalization of the neural crest. Development. 2020 10 26; 147(20). PMID: 33106325.
      View in: PubMed
    5. Beiriger A, Narayan S, Singh N, Prince V. Development and migration of the zebrafish rhombencephalic octavolateral efferent neurons. J Comp Neurol. 2021 05 01; 529(7):1293-1307. PMID: 32869305.
      View in: PubMed
    6. Guo M, Li Y, Su Y, Lambert T, Nogare DD, Moyle MW, Duncan LH, Ikegami R, Santella A, Rey-Suarez I, Green D, Beiriger A, Chen J, Vishwasrao H, Ganesan S, Prince V, Waters JC, Annunziata CM, Hafner M, Mohler WA, Chitnis AB, Upadhyaya A, Usdin TB, Bao Z, Colón-Ramos D, La Riviere P, Liu H, Wu Y, Shroff H. Rapid image deconvolution and multiview fusion for optical microscopy. Nat Biotechnol. 2020 11; 38(11):1337-1346. PMID: 32601431.
      View in: PubMed
    7. Rocha M, Singh N, Ahsan K, Beiriger A, Prince VE. Neural crest development: insights from the zebrafish. Dev Dyn. 2020 01; 249(1):88-111. PMID: 31591788.
      View in: PubMed
    8. Ahsan K, Singh N, Rocha M, Huang C, Prince VE. Prickle1 is required for EMT and migration of zebrafish cranial neural crest. Dev Biol. 2019 04 01; 448(1):16-35. PMID: 30721665.
      View in: PubMed
    9. Prince VE, Anderson RM, Dalgin G. Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies. Curr Top Dev Biol. 2017; 124:235-276. PMID: 28335861.
      View in: PubMed
    10. Dalgin G, Prince VE. Differential levels of Neurod establish zebrafish endocrine pancreas cell fates. Dev Biol. 2015 Jun 01; 402(1):81-97. PMID: 25797153.
      View in: PubMed
    11. Love CE, Prince VE. Rest represses maturation within migrating facial branchiomotor neurons. Dev Biol. 2015 May 15; 401(2):220-35. PMID: 25769695.
      View in: PubMed
    12. Wanner SJ, Saeger I, Guthrie S, Prince VE. Facial motor neuron migration advances. Curr Opin Neurobiol. 2013 Dec; 23(6):943-50. PMID: 24090878.
      View in: PubMed
    13. Wanner SJ, Prince VE. Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain. Development. 2013 Feb; 140(4):906-15. PMID: 23325758.
      View in: PubMed
    14. Eames SC, Kinkel MD, Rajan S, Prince VE, Philipson LH. Transgenic zebrafish model of the C43G human insulin gene mutation. J Diabetes Investig. 2013 Mar 18; 4(2):157-67. PMID: 24843647.
      View in: PubMed
    15. Kok FO, Taibi A, Wanner SJ, Xie X, Moravec CE, Love CE, Prince VE, Mumm JS, Sirotkin HI. Zebrafish rest regulates developmental gene expression but not neurogenesis. Development. 2012 Oct; 139(20):3838-48. PMID: 22951640.
      View in: PubMed
    16. Love CE, Prince VE. Expression and retinoic acid regulation of the zebrafish nr2f orphan nuclear receptor genes. Dev Dyn. 2012 Oct; 241(10):1603-15. PMID: 22836912.
      View in: PubMed
    17. Dalgin G, Prince VE. Mnx1: a gatekeeper of ß cell fate. Islets. 2012 Jul-Aug; 4(4):320-2. PMID: 22935732.
      View in: PubMed
    18. Dalgin G, Ward AB, Hao le T, Beattie CE, Nechiporuk A, Prince VE. Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas. Development. 2011 Nov; 138(21):4597-608. PMID: 21989909.
      View in: PubMed
    19. Mapp OM, Walsh GS, Moens CB, Tada M, Prince VE. Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity. Development. 2011 May; 138(10):2121-32. PMID: 21521740.
      View in: PubMed
    20. Kinkel MD, Eames SC, Philipson LH, Prince VE. Intraperitoneal injection into adult zebrafish. J Vis Exp. 2010 Aug 30; (42). PMID: 20834219.
      View in: PubMed
    21. Eames SC, Philipson LH, Prince VE, Kinkel MD. Blood sugar measurement in zebrafish reveals dynamics of glucose homeostasis. Zebrafish. 2010 Jun; 7(2):205-13. PMID: 20515318.
      View in: PubMed
    22. Mapp OM, Wanner SJ, Rohrschneider MR, Prince VE. Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. Dev Dyn. 2010 Jun; 239(6):1596-608. PMID: 20503357.
      View in: PubMed
    23. Prince VE, Kinkel MD. Recent advances in pancreas development: from embryonic pathways to programming renewable sources of beta cells. F1000 Biol Rep. 2010; 2:17. PMID: 20445833.
      View in: PubMed
    24. Bingham SM, Sittaramane V, Mapp O, Patil S, Prince VE, Chandrasekhar A. Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain. Dev Neurobiol. 2010 Feb; 70(2):87-99. PMID: 19937772.
      View in: PubMed
    25. Rajan S, Eames SC, Park SY, Labno C, Bell GI, Prince VE, Philipson LH. In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E403-10. PMID: 19952343.
      View in: PubMed
    26. Elsen GE, Choi LY, Prince VE, Ho RK. The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration. Dev Biol. 2009 Nov 01; 335(1):78-92. PMID: 19732764.
      View in: PubMed
    27. Aldinger KA, Elsen GE, Prince VE, Millen KJ. Model organisms inform the search for the genes and developmental pathology underlying malformations of the human hindbrain. Semin Pediatr Neurol. 2009 Sep; 16(3):155-63. PMID: 19778712.
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    28. Kinkel MD, Sefton EM, Kikuchi Y, Mizoguchi T, Ward AB, Prince VE. Cyp26 enzymes function in endoderm to regulate pancreatic field size. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7864-9. PMID: 19416885.
      View in: PubMed
    29. Kinkel MD, Prince VE. On the diabetic menu: zebrafish as a model for pancreas development and function. Bioessays. 2009 Feb; 31(2):139-52. PMID: 19204986.
      View in: PubMed
    30. Skromne I, Prince VE. Current perspectives in zebrafish reverse genetics: moving forward. Dev Dyn. 2008 Apr; 237(4):861-82. PMID: 18330930.
      View in: PubMed
    31. Kinkel MD, Eames SC, Alonzo MR, Prince VE. Cdx4 is required in the endoderm to localize the pancreas and limit beta-cell number. Development. 2008 Mar; 135(5):919-29. PMID: 18234725.
      View in: PubMed
    32. Elsen GE, Choi LY, Millen KJ, Grinblat Y, Prince VE. Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis. Dev Biol. 2008 Feb 15; 314(2):376-92. PMID: 18191121.
      View in: PubMed
    33. Hurley IA, Scemama JL, Prince VE. Consequences of hoxb1 duplication in teleost fish. Evol Dev. 2007 Nov-Dec; 9(6):540-54. PMID: 17976051.
      View in: PubMed
    34. Rohrschneider MR, Elsen GE, Prince VE. Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b. Dev Biol. 2007 Sep 15; 309(2):358-72. PMID: 17651720.
      View in: PubMed
    35. Ward AB, Warga RM, Prince VE. Origin of the zebrafish endocrine and exocrine pancreas. Dev Dyn. 2007 Jun; 236(6):1558-69. PMID: 17474119.
      View in: PubMed
    36. Skromne I, Thorsen D, Hale M, Prince VE, Ho RK. Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord. Development. 2007 Jun; 134(11):2147-58. PMID: 17507415.
      View in: PubMed
    37. Hurley IA, Mueller RL, Dunn KA, Schmidt EJ, Friedman M, Ho RK, Prince VE, Yang Z, Thomas MG, Coates MI. A new time-scale for ray-finned fish evolution. Proc Biol Sci. 2007 Feb 22; 274(1609):489-98. PMID: 17476768.
      View in: PubMed
    38. Hadrys T, Punnamoottil B, Pieper M, Kikuta H, Pezeron G, Becker TS, Prince V, Baker R, Rinkwitz S. Conserved co-regulation and promoter sharing of hoxb3a and hoxb4a in zebrafish. Dev Biol. 2006 Sep 01; 297(1):26-43. PMID: 16860306.
      View in: PubMed
    39. Stafford D, White RJ, Kinkel MD, Linville A, Schilling TF, Prince VE. Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells. Development. 2006 Mar; 133(5):949-56. PMID: 16452093.
      View in: PubMed
    40. Hurley I, Hale ME, Prince VE. Duplication events and the evolution of segmental identity. Evol Dev. 2005 Nov-Dec; 7(6):556-67. PMID: 16336409.
      View in: PubMed
    41. Hogan BM, Hunter MP, Oates AC, Crowhurst MO, Hall NE, Heath JK, Prince VE, Lieschke GJ. Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Dev Biol. 2004 Dec 15; 276(2):508-22. PMID: 15581882.
      View in: PubMed
    42. Stafford D, Hornbruch A, Mueller PR, Prince VE. A conserved role for retinoid signaling in vertebrate pancreas development. Dev Genes Evol. 2004 Sep; 214(9):432-41. PMID: 15322880.
      View in: PubMed
    43. Hale ME, Kheirbek MA, Schriefer JE, Prince VE. Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons. J Neurosci. 2004 Mar 24; 24(12):3070-6. PMID: 15044546.
      View in: PubMed
    44. Hadrys T, Prince V, Hunter M, Baker R, Rinkwitz S. Comparative genomic analysis of vertebrate Hox3 and Hox4 genes. J Exp Zool B Mol Dev Evol. 2004 Mar 15; 302(2):147-64. PMID: 15054858.
      View in: PubMed
    45. McClintock JM, Jozefowicz C, Assimacopoulos S, Grove EA, Louvi A, Prince VE. Conserved expression of Hoxa1 in neurons at the ventral forebrain/midbrain boundary of vertebrates. Dev Genes Evol. 2003 Aug; 213(8):399-406. PMID: 12748854.
      View in: PubMed
    46. Jozefowicz C, McClintock J, Prince V. The fates of zebrafish Hox gene duplicates. J Struct Funct Genomics. 2003; 3(1-4):185-94. PMID: 12836697.
      View in: PubMed
    47. Prince VE, Pickett FB. Splitting pairs: the diverging fates of duplicated genes. Nat Rev Genet. 2002 Nov; 3(11):827-37. PMID: 12415313.
      View in: PubMed
    48. Scemama JL, Hunter M, McCallum J, Prince V, Stellwag E. Evolutionary divergence of vertebrate Hoxb2 expression patterns and transcriptional regulatory loci. J Exp Zool. 2002 Oct 15; 294(3):285-99. PMID: 12362434.
      View in: PubMed
    49. Prince V. The Hox Paradox: More complex(es) than imagined. Dev Biol. 2002 Sep 01; 249(1):1-15. PMID: 12217314.
      View in: PubMed
    50. Stafford D, Prince VE. Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Curr Biol. 2002 Jul 23; 12(14):1215-20. PMID: 12176331.
      View in: PubMed
    51. Hunter MP, Prince VE. Zebrafish hox paralogue group 2 genes function redundantly as selector genes to pattern the second pharyngeal arch. Dev Biol. 2002 Jul 15; 247(2):367-89. PMID: 12086473.
      View in: PubMed
    52. Moens CB, Prince VE. Constructing the hindbrain: insights from the zebrafish. Dev Dyn. 2002 May; 224(1):1-17. PMID: 11984869.
      View in: PubMed
    53. McClintock JM, Kheirbek MA, Prince VE. Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention. Development. 2002 May; 129(10):2339-54. PMID: 11973267.
      View in: PubMed
    54. Hauptmann G, Belting HG, Wolke U, Lunde K, Söll I, Abdelilah-Seyfried S, Prince V, Driever W. spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Development. 2002 Apr; 129(7):1645-55. PMID: 11923201.
      View in: PubMed
    55. Prince VE, Holley SA, Bally-Cuif L, Prabhakaran B, Oates AC, Ho RK, Vogt TF. Zebrafish lunatic fringe demarcates segmental boundaries. Mech Dev. 2001 Jul; 105(1-2):175-80. PMID: 11429294.
      View in: PubMed
    56. McClintock JM, Carlson R, Mann DM, Prince VE. Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes. Development. 2001 Jul; 128(13):2471-84. PMID: 11493564.
      View in: PubMed
    57. Bruce AE, Oates AC, Prince VE, Ho RK. Additional hox clusters in the zebrafish: divergent expression patterns belie equivalent activities of duplicate hoxB5 genes. Evol Dev. 2001 May-Jun; 3(3):127-44. PMID: 11440248.
      View in: PubMed
    58. Zerucha T, Prince VE. Cloning and developmental expression of a zebrafish meis2 homeobox gene. Mech Dev. 2001 Apr; 102(1-2):247-50. PMID: 11287203.
      View in: PubMed
    59. Schilling TF, Prince V, Ingham PW. Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest. Dev Biol. 2001 Mar 01; 231(1):201-16. PMID: 11180963.
      View in: PubMed
    60. Patel NH, Prince VE. Beyond the Hox complex. Genome Biol. 2000; 1(5):REVIEWS1027. PMID: 11178261.
      View in: PubMed
    61. Roy MN, Prince VE, Ho RK. Heat shock produces periodic somitic disturbances in the zebrafish embryo. Mech Dev. 1999 Jul; 85(1-2):27-34. PMID: 10415344.
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    62. Amores A, Force A, Yan YL, Joly L, Amemiya C, Fritz A, Ho RK, Langeland J, Prince V, Wang YL, Westerfield M, Ekker M, Postlethwait JH. Zebrafish hox clusters and vertebrate genome evolution. Science. 1998 Nov 27; 282(5394):1711-4. PMID: 9831563.
      View in: PubMed
    63. Prince VE, Price AL, Ho RK. Hox gene expression reveals regionalization along the anteroposterior axis of the zebrafish notochord. Dev Genes Evol. 1998 Nov; 208(9):517-22. PMID: 9799433.
      View in: PubMed
    64. Prince VE, Moens CB, Kimmel CB, Ho RK. Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino. Development. 1998 Feb; 125(3):393-406. PMID: 9425135.
      View in: PubMed
    65. Prince VE, Joly L, Ekker M, Ho RK. Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk. Development. 1998 Feb; 125(3):407-20. PMID: 9425136.
      View in: PubMed
    66. Gale E, Prince V, Lumsden A, Clarke J, Holder N, Maden M. Late effects of retinoic acid on neural crest and aspects of rhombomere. Development. 1996 Mar; 122(3):783-93. PMID: 8631256.
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    67. Prince V, Lumsden A. Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest. Development. 1994 Apr; 120(4):911-23. PMID: 7600967.
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    68. Guthrie S, Prince V, Lumsden A. Selective dispersal of avian rhombomere cells in orthotopic and heterotopic grafts. Development. 1993 Jun; 118(2):527-38. PMID: 8223277.
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    69. Prince VE, Rigby PW. Derivatives of Moloney murine sarcoma virus capable of being transcribed in embryonal carcinoma stem cells have gained a functional Sp1 binding site. J Virol. 1991 Apr; 65(4):1803-11. PMID: 1848307.
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