Victoria E. Prince
Title | Professor |
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Institution | University of Chicago |
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Department | Organismal Biology and Anatomy |
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Address | Chicago IL 60637
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Email |  |
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vCard | Download vCard |
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Overview My research program at the University of Chicago focuses on vertebrate axial regionalization during development using the zebrafish as a model. My group takes a variety of molecular, cellular and genetic approaches to these studies, and we have made important contributions to a variety of research areas, including the understanding of Hox gene regulation of hindbrain patterning, evolution of duplicated genes and genomes in the vertebrates, and patterning of endoderm-derived tissues. Active areas of research in my lab include continuing studies of hindbrain patterning, with an emphasis on understanding neuronal and neural crest migration.
Biography Imperial College, London University, London | BS | 06/1986 | Biochemistry | University College, London University, London | PhD | 01/1991 | Molecular Biology | University of London, Guy's Hospital, London | Postdoc | 06/1994 | Developmental Neuro | Princeton University, Princeton, NJ | Postdoc | 07/1997 | Developmental Bio |
2015 - 2024 | Marshal of the University, The University of Chicago | 2016 - 2016 | Faculty Leadership Award in Program Innovation, University of Chicago | 2010 - 2011 | Academic Leadership Fellowship, CIC/University of Chicago | 2006 - 2006 | J &J Neubauer Faculty Development Fellowship in recognition of teaching excellence in the College, University of Chicago | 2005 - 2005 | The Christianna Smith Lecturer, Mount Holyoke College | 2005 - 2010 | Faculty of 1000 | 1995 - 1997 | Human Frontiers Science Program Fellowship, Princeton University | 1994 - 1995 | EMBO Long-Term Fellowship, Princeton University | 1992 - 1994 | Medical Research Council (UK) Training Fellowship |
ORNG Applications Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Alhashem Z, Feldner-Busztin D, Revell C, Alvarez-Garcillan Portillo M, Camargo-Sosa K, Richardson J, Rocha M, Gauert A, Corbeaux T, Milanetto M, Argenton F, Tiso N, Kelsh R, Prince VE, Bentley K, Linker C. Notch controls the cell cycle to define leader versus follower identities during collective cell migration. Elife. 2022 Apr 19; 11. PMID: 35438077.
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Rocha M, Kushkowski E, Schnirman R, Booth C, Singh N, Beadell A, Prince VE. Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body. Dev Biol. 2021 12; 480:25-38. PMID: 34389276.
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Dalgin G, Prince VE. Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b. Dev Biol. 2021 03; 471:1-9. PMID: 33290819.
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Rocha M, Beiriger A, Kushkowski EE, Miyashita T, Singh N, Venkataraman V, Prince VE. From head to tail: regionalization of the neural crest. Development. 2020 10 26; 147(20). PMID: 33106325.
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Beiriger A, Narayan S, Singh N, Prince V. Development and migration of the zebrafish rhombencephalic octavolateral efferent neurons. J Comp Neurol. 2021 05 01; 529(7):1293-1307. PMID: 32869305.
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Guo M, Li Y, Su Y, Lambert T, Nogare DD, Moyle MW, Duncan LH, Ikegami R, Santella A, Rey-Suarez I, Green D, Beiriger A, Chen J, Vishwasrao H, Ganesan S, Prince V, Waters JC, Annunziata CM, Hafner M, Mohler WA, Chitnis AB, Upadhyaya A, Usdin TB, Bao Z, Colón-Ramos D, La Riviere P, Liu H, Wu Y, Shroff H. Rapid image deconvolution and multiview fusion for optical microscopy. Nat Biotechnol. 2020 11; 38(11):1337-1346. PMID: 32601431.
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Rocha M, Singh N, Ahsan K, Beiriger A, Prince VE. Neural crest development: insights from the zebrafish. Dev Dyn. 2020 01; 249(1):88-111. PMID: 31591788.
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Ahsan K, Singh N, Rocha M, Huang C, Prince VE. Prickle1 is required for EMT and migration of zebrafish cranial neural crest. Dev Biol. 2019 04 01; 448(1):16-35. PMID: 30721665.
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Prince VE, Anderson RM, Dalgin G. Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies. Curr Top Dev Biol. 2017; 124:235-276. PMID: 28335861.
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Dalgin G, Prince VE. Differential levels of Neurod establish zebrafish endocrine pancreas cell fates. Dev Biol. 2015 Jun 01; 402(1):81-97. PMID: 25797153.
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Love CE, Prince VE. Rest represses maturation within migrating facial branchiomotor neurons. Dev Biol. 2015 May 15; 401(2):220-35. PMID: 25769695.
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Wanner SJ, Saeger I, Guthrie S, Prince VE. Facial motor neuron migration advances. Curr Opin Neurobiol. 2013 Dec; 23(6):943-50. PMID: 24090878.
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Wanner SJ, Prince VE. Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain. Development. 2013 Feb; 140(4):906-15. PMID: 23325758.
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Eames SC, Kinkel MD, Rajan S, Prince VE, Philipson LH. Transgenic zebrafish model of the C43G human insulin gene mutation. J Diabetes Investig. 2013 Mar 18; 4(2):157-67. PMID: 24843647.
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Kok FO, Taibi A, Wanner SJ, Xie X, Moravec CE, Love CE, Prince VE, Mumm JS, Sirotkin HI. Zebrafish rest regulates developmental gene expression but not neurogenesis. Development. 2012 Oct; 139(20):3838-48. PMID: 22951640.
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Love CE, Prince VE. Expression and retinoic acid regulation of the zebrafish nr2f orphan nuclear receptor genes. Dev Dyn. 2012 Oct; 241(10):1603-15. PMID: 22836912.
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Dalgin G, Prince VE. Mnx1: a gatekeeper of ß cell fate. Islets. 2012 Jul-Aug; 4(4):320-2. PMID: 22935732.
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Dalgin G, Ward AB, Hao le T, Beattie CE, Nechiporuk A, Prince VE. Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas. Development. 2011 Nov; 138(21):4597-608. PMID: 21989909.
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Mapp OM, Walsh GS, Moens CB, Tada M, Prince VE. Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity. Development. 2011 May; 138(10):2121-32. PMID: 21521740.
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Kinkel MD, Eames SC, Philipson LH, Prince VE. Intraperitoneal injection into adult zebrafish. J Vis Exp. 2010 Aug 30; (42). PMID: 20834219.
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Eames SC, Philipson LH, Prince VE, Kinkel MD. Blood sugar measurement in zebrafish reveals dynamics of glucose homeostasis. Zebrafish. 2010 Jun; 7(2):205-13. PMID: 20515318.
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Mapp OM, Wanner SJ, Rohrschneider MR, Prince VE. Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. Dev Dyn. 2010 Jun; 239(6):1596-608. PMID: 20503357.
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Prince VE, Kinkel MD. Recent advances in pancreas development: from embryonic pathways to programming renewable sources of beta cells. F1000 Biol Rep. 2010; 2:17. PMID: 20445833.
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Bingham SM, Sittaramane V, Mapp O, Patil S, Prince VE, Chandrasekhar A. Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain. Dev Neurobiol. 2010 Feb; 70(2):87-99. PMID: 19937772.
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Rajan S, Eames SC, Park SY, Labno C, Bell GI, Prince VE, Philipson LH. In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E403-10. PMID: 19952343.
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Elsen GE, Choi LY, Prince VE, Ho RK. The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration. Dev Biol. 2009 Nov 01; 335(1):78-92. PMID: 19732764.
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Aldinger KA, Elsen GE, Prince VE, Millen KJ. Model organisms inform the search for the genes and developmental pathology underlying malformations of the human hindbrain. Semin Pediatr Neurol. 2009 Sep; 16(3):155-63. PMID: 19778712.
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Kinkel MD, Sefton EM, Kikuchi Y, Mizoguchi T, Ward AB, Prince VE. Cyp26 enzymes function in endoderm to regulate pancreatic field size. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7864-9. PMID: 19416885.
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Kinkel MD, Prince VE. On the diabetic menu: zebrafish as a model for pancreas development and function. Bioessays. 2009 Feb; 31(2):139-52. PMID: 19204986.
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Skromne I, Prince VE. Current perspectives in zebrafish reverse genetics: moving forward. Dev Dyn. 2008 Apr; 237(4):861-82. PMID: 18330930.
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Kinkel MD, Eames SC, Alonzo MR, Prince VE. Cdx4 is required in the endoderm to localize the pancreas and limit beta-cell number. Development. 2008 Mar; 135(5):919-29. PMID: 18234725.
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Elsen GE, Choi LY, Millen KJ, Grinblat Y, Prince VE. Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis. Dev Biol. 2008 Feb 15; 314(2):376-92. PMID: 18191121.
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Hurley IA, Scemama JL, Prince VE. Consequences of hoxb1 duplication in teleost fish. Evol Dev. 2007 Nov-Dec; 9(6):540-54. PMID: 17976051.
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Rohrschneider MR, Elsen GE, Prince VE. Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b. Dev Biol. 2007 Sep 15; 309(2):358-72. PMID: 17651720.
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Ward AB, Warga RM, Prince VE. Origin of the zebrafish endocrine and exocrine pancreas. Dev Dyn. 2007 Jun; 236(6):1558-69. PMID: 17474119.
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Skromne I, Thorsen D, Hale M, Prince VE, Ho RK. Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord. Development. 2007 Jun; 134(11):2147-58. PMID: 17507415.
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Hurley IA, Mueller RL, Dunn KA, Schmidt EJ, Friedman M, Ho RK, Prince VE, Yang Z, Thomas MG, Coates MI. A new time-scale for ray-finned fish evolution. Proc Biol Sci. 2007 Feb 22; 274(1609):489-98. PMID: 17476768.
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Hadrys T, Punnamoottil B, Pieper M, Kikuta H, Pezeron G, Becker TS, Prince V, Baker R, Rinkwitz S. Conserved co-regulation and promoter sharing of hoxb3a and hoxb4a in zebrafish. Dev Biol. 2006 Sep 01; 297(1):26-43. PMID: 16860306.
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Stafford D, White RJ, Kinkel MD, Linville A, Schilling TF, Prince VE. Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells. Development. 2006 Mar; 133(5):949-56. PMID: 16452093.
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Hurley I, Hale ME, Prince VE. Duplication events and the evolution of segmental identity. Evol Dev. 2005 Nov-Dec; 7(6):556-67. PMID: 16336409.
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Hogan BM, Hunter MP, Oates AC, Crowhurst MO, Hall NE, Heath JK, Prince VE, Lieschke GJ. Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Dev Biol. 2004 Dec 15; 276(2):508-22. PMID: 15581882.
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Stafford D, Hornbruch A, Mueller PR, Prince VE. A conserved role for retinoid signaling in vertebrate pancreas development. Dev Genes Evol. 2004 Sep; 214(9):432-41. PMID: 15322880.
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Hale ME, Kheirbek MA, Schriefer JE, Prince VE. Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons. J Neurosci. 2004 Mar 24; 24(12):3070-6. PMID: 15044546.
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Hadrys T, Prince V, Hunter M, Baker R, Rinkwitz S. Comparative genomic analysis of vertebrate Hox3 and Hox4 genes. J Exp Zool B Mol Dev Evol. 2004 Mar 15; 302(2):147-64. PMID: 15054858.
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McClintock JM, Jozefowicz C, Assimacopoulos S, Grove EA, Louvi A, Prince VE. Conserved expression of Hoxa1 in neurons at the ventral forebrain/midbrain boundary of vertebrates. Dev Genes Evol. 2003 Aug; 213(8):399-406. PMID: 12748854.
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Jozefowicz C, McClintock J, Prince V. The fates of zebrafish Hox gene duplicates. J Struct Funct Genomics. 2003; 3(1-4):185-94. PMID: 12836697.
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Prince VE, Pickett FB. Splitting pairs: the diverging fates of duplicated genes. Nat Rev Genet. 2002 Nov; 3(11):827-37. PMID: 12415313.
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Scemama JL, Hunter M, McCallum J, Prince V, Stellwag E. Evolutionary divergence of vertebrate Hoxb2 expression patterns and transcriptional regulatory loci. J Exp Zool. 2002 Oct 15; 294(3):285-99. PMID: 12362434.
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Prince V. The Hox Paradox: More complex(es) than imagined. Dev Biol. 2002 Sep 01; 249(1):1-15. PMID: 12217314.
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Stafford D, Prince VE. Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Curr Biol. 2002 Jul 23; 12(14):1215-20. PMID: 12176331.
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Hunter MP, Prince VE. Zebrafish hox paralogue group 2 genes function redundantly as selector genes to pattern the second pharyngeal arch. Dev Biol. 2002 Jul 15; 247(2):367-89. PMID: 12086473.
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Moens CB, Prince VE. Constructing the hindbrain: insights from the zebrafish. Dev Dyn. 2002 May; 224(1):1-17. PMID: 11984869.
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McClintock JM, Kheirbek MA, Prince VE. Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention. Development. 2002 May; 129(10):2339-54. PMID: 11973267.
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Hauptmann G, Belting HG, Wolke U, Lunde K, Söll I, Abdelilah-Seyfried S, Prince V, Driever W. spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Development. 2002 Apr; 129(7):1645-55. PMID: 11923201.
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Prince VE, Holley SA, Bally-Cuif L, Prabhakaran B, Oates AC, Ho RK, Vogt TF. Zebrafish lunatic fringe demarcates segmental boundaries. Mech Dev. 2001 Jul; 105(1-2):175-80. PMID: 11429294.
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McClintock JM, Carlson R, Mann DM, Prince VE. Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes. Development. 2001 Jul; 128(13):2471-84. PMID: 11493564.
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Bruce AE, Oates AC, Prince VE, Ho RK. Additional hox clusters in the zebrafish: divergent expression patterns belie equivalent activities of duplicate hoxB5 genes. Evol Dev. 2001 May-Jun; 3(3):127-44. PMID: 11440248.
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Zerucha T, Prince VE. Cloning and developmental expression of a zebrafish meis2 homeobox gene. Mech Dev. 2001 Apr; 102(1-2):247-50. PMID: 11287203.
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Schilling TF, Prince V, Ingham PW. Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest. Dev Biol. 2001 Mar 01; 231(1):201-16. PMID: 11180963.
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Patel NH, Prince VE. Beyond the Hox complex. Genome Biol. 2000; 1(5):REVIEWS1027. PMID: 11178261.
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Roy MN, Prince VE, Ho RK. Heat shock produces periodic somitic disturbances in the zebrafish embryo. Mech Dev. 1999 Jul; 85(1-2):27-34. PMID: 10415344.
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Amores A, Force A, Yan YL, Joly L, Amemiya C, Fritz A, Ho RK, Langeland J, Prince V, Wang YL, Westerfield M, Ekker M, Postlethwait JH. Zebrafish hox clusters and vertebrate genome evolution. Science. 1998 Nov 27; 282(5394):1711-4. PMID: 9831563.
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Prince VE, Price AL, Ho RK. Hox gene expression reveals regionalization along the anteroposterior axis of the zebrafish notochord. Dev Genes Evol. 1998 Nov; 208(9):517-22. PMID: 9799433.
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Prince VE, Moens CB, Kimmel CB, Ho RK. Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino. Development. 1998 Feb; 125(3):393-406. PMID: 9425135.
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Prince VE, Joly L, Ekker M, Ho RK. Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk. Development. 1998 Feb; 125(3):407-20. PMID: 9425136.
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Gale E, Prince V, Lumsden A, Clarke J, Holder N, Maden M. Late effects of retinoic acid on neural crest and aspects of rhombomere. Development. 1996 Mar; 122(3):783-93. PMID: 8631256.
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Prince V, Lumsden A. Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest. Development. 1994 Apr; 120(4):911-23. PMID: 7600967.
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Guthrie S, Prince V, Lumsden A. Selective dispersal of avian rhombomere cells in orthotopic and heterotopic grafts. Development. 1993 Jun; 118(2):527-38. PMID: 8223277.
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Prince VE, Rigby PW. Derivatives of Moloney murine sarcoma virus capable of being transcribed in embryonal carcinoma stem cells have gained a functional Sp1 binding site. J Virol. 1991 Apr; 65(4):1803-11. PMID: 1848307.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1991 | 1 | 1993 | 1 | 1994 | 1 | 1996 | 1 | 1998 | 4 | 1999 | 1 | 2000 | 1 | 2001 | 5 | 2002 | 8 | 2003 | 2 | 2004 | 4 | 2005 | 1 | 2006 | 2 | 2007 | 6 | 2008 | 2 | 2009 | 5 | 2010 | 5 | 2011 | 2 | 2012 | 4 | 2013 | 2 | 2015 | 2 | 2016 | 1 | 2019 | 2 | 2020 | 4 | 2021 | 1 | 2022 | 1 |
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