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Bakhtiar Yamini

InstitutionUniversity of Chicago
DepartmentNeurological Surgery
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    University of Chicago MedicineResidencyNeurological Surgery
    University of Chicago MedicineInternshipGeneral Surgery
    University of Michigan Medical SchoolMD

    Collapse Research 
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    U01NS069997     (YAMINI, BAKHTIAR)Jul 1, 2010 - Jun 30, 2016
    Neural Stem Cell Based Virotherapy for Malignant Glioma
    Role: Principal Investigator

    R01CA136937     (YAMINI, BAKHTIAR)Dec 1, 2008 - Jun 30, 2021
    NF-kB1-p50 in the Response to DNA Alkylation Damage
    Role: Principal Investigator

    R44CA135906     (SPRETZ, RUBEN)Sep 12, 2008 - Aug 31, 2015
    Nanoparticles and Nanocapsules for Glioma Targeting
    Role: Co-Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Driscoll RK, Lyne SB, Voce DJ, Maraka S, Gondi V, Chmura SJ, Dixit KS, Kumthekar PU, Karrison TG, Pytel P, Collins JM, Stupp R, Merrell RT, Lukas RV, Yamini B. A multi-institutional phase I study of acetazolamide with temozolomide in adults with newly diagnosed MGMT-methylated malignant glioma. Neurooncol Adv. 2024 Jan-Dec; 6(1):vdae014. PMID: 38420615; PMCID: PMC10901541.
    2. Johnson M, Bell A, Lauing KL, Ladomersky E, Zhai L, Penco-Campillo M, Shah Y, Mauer E, Xiu J, Nicolaides T, Drumm M, McCortney K, Elemento O, Kim M, Bommi P, Low JT, Memon R, Wu J, Zhao J, Mi X, Glantz MJ, Sengupta S, Castro B, Yamini B, Horbinski C, Baker DJ, Walunas TL, Schiltz GE, Lukas RV, Wainwright DA. Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence. Clin Cancer Res. 2023 12 01; 29(23):4973-4989. PMID: 37725593; PMCID: PMC10690140.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. Hosseini SS, Yamini B, Ichkitidze L, Asadi M, Fernandez J, Gholampour S. Enhanced Ionic Polymer-Metal Composites with Nanocomposite Electrodes for Restoring Eyelid Movement of Patients with Ptosis. Nanomaterials (Basel). 2023 Jan 24; 13(3). PMID: 36770434; PMCID: PMC9920823.
      Citations: 2     
    4. Bollu LR, Bommi PV, Monsen PJ, Zhai L, Lauing KL, Bell A, Kim M, Ladomersky E, Yang X, Platanias LC, Matei DE, Bonini MG, Munshi HG, Hashizume R, Wu JD, Zhang B, James CD, Chen P, Kocherginsky M, Horbinski C, Cameron MD, Grigorescu AA, Yamini B, Lukas RV, Schiltz GE, Wainwright DA. Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma. J Med Chem. 2022 12 08; 65(23):15642-15662. PMID: 36410047; PMCID: PMC9743093.
      Citations: 4     Fields:    Translation:HumansAnimals
    5. Gholampour S, Frim D, Yamini B. Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting. Commun Biol. 2022 Nov 08; 5(1):1198. PMID: 36344582; PMCID: PMC9640582.
      Citations: 9     Translation:Humans
    6. Gholampour S, Balasundaram H, Thiyagarajan P, Droessler J. A mathematical framework for the dynamic interaction of pulsatile blood, brain, and cerebrospinal fluid. Comput Methods Programs Biomed. 2023 Apr; 231:107209. PMID: 36796166.
      Citations: 7     Fields:    Translation:Humans
    7. Papazian E, Adams D, Du M, Wang E, Caballero N, Das P, Horowitz P, Pinto J, Portugal L, Yamini B, Roxbury CR. Practice patterns and provider satisfaction in a virtual rhinology and skull base surgery clinic. Int Forum Allergy Rhinol. 2023 05; 13(5):946-949. PMID: 36174968.
      Citations:    Fields:    Translation:Humans
    8. Gholampour S, Yamini B, Droessler J, Frim D. A New Definition for Intracranial Compliance to Evaluate Adult Hydrocephalus After Shunting. Front Bioeng Biotechnol. 2022; 10:900644. PMID: 35979170; PMCID: PMC9377221.
      Citations: 11     
    9. Gholampour S, Patel J, Yamini B, Frim D. Cerebrospinal fluid hydrocephalus shunting: cisterna magna, ventricular frontal, ventricular occipital. Neurosurg Rev. 2022 Aug; 45(4):2615-2638. PMID: 35513737.
      Citations: 5     Fields:    Translation:Humans
    10. Bernal GM, Wu L, Voce DJ, Weichselbaum RR, Yamini B. p52 signaling promotes cellular senescence. Cell Biosci. 2022 Apr 04; 12(1):43. PMID: 35379326; PMCID: PMC8981737.
      Citations: 1     
    11. Du M, Papazian E, Adams D, Caballero N, Portugal L, Das P, Horowitz P, Yamini B, Pinto JM, Roxbury CR. Patient satisfaction with telemedicine is noninferior to in-office visits: Lessons from a tertiary rhinology and endoscopic skull base surgery practice. Int Forum Allergy Rhinol. 2022 05; 12(5):802-804. PMID: 34596970.
      Citations: 3     Fields:    Translation:Humans
    12. Kim M, Ladomersky E, Mozny A, Kocherginsky M, O'Shea K, Reinstein ZZ, Zhai L, Bell A, Lauing KL, Bollu L, Rabin E, Dixit K, Kumthekar P, Platanias LC, Hou L, Zheng Y, Wu J, Zhang B, Hrachova M, Merrill SA, Mrugala MM, Prabhu VC, Horbinski C, James CD, Yamini B, Ostrom QT, Johnson MO, Reardon DA, Lukas RV, Wainwright DA. Glioblastoma as an age-related neurological disorder in adults. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab125. PMID: 34647022; PMCID: PMC8500689.
      Citations: 27     
    13. Mansour A, Loggini A, El Ammar F, Alvarado-Dyer R, Polster S, Stadnik A, Das P, Warnke PC, Yamini B, Lazaridis C, Kramer C, Mould WA, Hildreth M, Sharrock M, Hanley DF, Goldenberg FD, Awad IA. Post-Trial Enhanced Deployment and Technical Performance with the MISTIE Procedure per Lessons Learned. J Stroke Cerebrovasc Dis. 2021 Sep; 30(9):105996. PMID: 34303090; PMCID: PMC8384714.
      Citations:    Fields:    Translation:Humans
    14. Yamini B, Lyne SB. An Alternative Pipeline for Glioblastoma Therapeutics: A Systematic Review of Drug Repurposing in Glioblastoma. Cancers (Basel). 2021 Apr 18; 13(8). PMID: 33919596; PMCID: PMC8073966.
      Citations: 15     
    15. Voce DJ, Bernal GM, Cahill KE, Wu L, Mansour N, Crawley CD, Campbell PS, Arina A, Weichselbaum RR, Yamini B. CDK1 is up-regulated by temozolomide in an NF-?B dependent manner in glioblastoma. Sci Rep. 2021 03 11; 11(1):5665. PMID: 33707466; PMCID: PMC7952566.
      Citations: 7     Fields:    Translation:HumansCells
    16. Wu L, Crawley CD, Garofalo A, Nichols JW, Campbell PA, Khramtsova GF, Olopade OI, Weichselbaum RR, Yamini B. p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability. Nat Commun. 2020 10 06; 11(1):5007. PMID: 33024116; PMCID: PMC7538584.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    17. Szymura SJ, Bernal GM, Wu L, Zhang Z, Crawley CD, Voce DJ, Campbell PA, Ranoa DE, Weichselbaum RR, Yamini B. DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-?B and sensitize to alkylating chemotherapy. BMC Biol. 2020 03 24; 18(1):32. PMID: 32209106; PMCID: PMC7093963.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    18. Chiocca EA, Yu JS, Lukas RV, Solomon IH, Ligon KL, Nakashima H, Triggs DA, Reardon DA, Wen P, Stopa BM, Naik A, Rudnick J, Hu JL, Kumthekar P, Yamini B, Buck JY, Demars N, Barrett JA, Gelb AB, Zhou J, Lebel F, Cooper LJN. Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. 2019 08 14; 11(505). PMID: 31413142; PMCID: PMC7286430.
      Citations: 112     Fields:    Translation:HumansCTClinical Trials
    19. Voce DJ, Bernal GM, Wu L, Crawley CD, Zhang W, Mansour NM, Cahill KE, Szymura SJ, Uppal A, Raleigh DR, Spretz R, Nunez L, Larsen G, Khodarev NN, Weichselbaum RR, Yamini B. Temozolomide Treatment Induces lncRNA MALAT1 in an NF-?B and p53 Codependent Manner in Glioblastoma. Cancer Res. 2019 05 15; 79(10):2536-2548. PMID: 30940658; PMCID: PMC6522287.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    20. Polster SP, Fidai S, Pytel P, Yamini B, Lyne SB. Primary Sellar Paraganglioma: Case Report with Literature Review and Immunohistochemistry Resource. World Neurosurg. 2019 05; 125:32-36. PMID: 30703592.
      Citations: 5     Fields:    Translation:Humans
    21. Hussain F, Horbinski CM, Chmura SJ, Yamini B, Lukas RV. Response to BRAF/MEK Inhibition After Progression With BRAF Inhibition in a Patient With Anaplastic Pleomorphic Xanthoastrocytoma. Neurologist. 2018 Sep; 23(5):163-166. PMID: 30169370.
      Citations: 6     Fields:    Translation:Humans
    22. Yamini B. NF-?B, Mesenchymal Differentiation and Glioblastoma. Cells. 2018 Aug 31; 7(9). PMID: 30200302; PMCID: PMC6162779.
      Citations: 29     Fields:    
    23. Wu L, Bernal GM, Cahill KE, Pytel P, Fitzpatrick CA, Mashek H, Weichselbaum RR, Yamini B. BCL3 expression promotes resistance to alkylating chemotherapy in gliomas. Sci Transl Med. 2018 07 04; 10(448). PMID: 29973405; PMCID: PMC6613219.
      Citations: 32     Fields:    Translation:HumansCells
    24. Young JS, Bernal G, Polster SP, Nunez L, Larsen GF, Mansour N, Podell M, Yamini B. Convection-Enhanced Delivery of Polymeric Nanoparticles Encapsulating Chemotherapy in Canines with Spontaneous Supratentorial Tumors. World Neurosurg. 2018 Sep; 117:e698-e704. PMID: 29960096; PMCID: PMC6113082.
      Citations: 24     Fields:    Translation:AnimalsCTClinical Trials
    25. Hobbs JG, Van Slambrouck C, Miller JL, Yamini B. Intracranial hemorrhage as initial manifestation of plasma cell myeloma: A case report. J Clin Neurosci. 2018 Apr; 50:133-135. PMID: 29428262.
      Citations: 1     Fields:    Translation:Humans
    26. Young JS, Chmura SJ, Wainwright DA, Yamini B, Peters KB, Lukas RV. Management of glioblastoma in elderly patients. J Neurol Sci. 2017 Sep 15; 380:250-255. PMID: 28870580; PMCID: PMC7328157.
      Citations: 26     Fields:    Translation:Humans
    27. Cahill KE, Morshed RA, Yamini B. Nuclear factor-?B in glioblastoma: insights into regulators and targeted therapy. Neuro Oncol. 2016 Mar; 18(3):329-39. PMID: 26534766; PMCID: PMC4767244.
      Citations: 78     Fields:    Translation:HumansAnimals
    28. Mansour NM, Bernal GM, Wu L, Crawley CD, Cahill KE, Voce DJ, Balyasnikova IV, Zhang W, Spretz R, Nunez L, Larsen GF, Weichselbaum RR, Yamini B. Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide. Cancer Res. 2015 May 15; 75(10):2039-48. PMID: 25808868; PMCID: PMC4433625.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    29. Yamini B. Nfkb1/p50 and mammalian aging. Oncotarget. 2015 Feb 28; 6(6):3471-2. PMID: 25704886; PMCID: PMC4414126.
      Citations: 1     Fields:    Translation:HumansAnimals
    30. Schmitt AM, Yamini B. Nfkb1 suppresses DNA alkylation-induced tumor formation. Mol Cell Oncol. 2015 Jan-Mar; 2(1):e968073. PMID: 27308399; PMCID: PMC4905238.
      Citations: 1     
    31. Crawley CD, Kang S, Bernal GM, Wahlstrom JS, Voce DJ, Cahill KE, Garofalo A, Raleigh DR, Weichselbaum RR, Yamini B. S-phase-dependent p50/NF-?B1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability. Cell Cycle. 2015; 14(4):566-76. PMID: 25590437; PMCID: PMC4614791.
      Citations: 11     Fields:    Translation:HumansCells
    32. Bernal GM, Wahlstrom JS, Crawley CD, Cahill KE, Pytel P, Liang H, Kang S, Weichselbaum RR, Yamini B. Loss of Nfkb1 leads to early onset aging. Aging (Albany NY). 2014 Nov; 6(11):931-43. PMID: 25553648; PMCID: PMC4276787.
      Citations: 46     Fields:    Translation:AnimalsCells
    33. Voce DJ, Schmitt AM, Uppal A, McNerney ME, Bernal GM, Cahill KE, Wahlstrom JS, Nassiri A, Yu X, Crawley CD, White KP, Onel K, Weichselbaum RR, Yamini B. Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor. Oncogene. 2015 May 21; 34(21):2807-13. PMID: 25043302; PMCID: PMC4302074.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    34. Bernal GM, LaRiviere MJ, Mansour N, Pytel P, Cahill KE, Voce DJ, Kang S, Spretz R, Welp U, Noriega SE, Nunez L, Larsen GF, Weichselbaum RR, Yamini B. Convection-enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma. Nanomedicine. 2014 Jan; 10(1):149-57. PMID: 23891990; PMCID: PMC3871979.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    35. Crawley CD, Raleigh DR, Kang S, Voce DJ, Schmitt AM, Weichselbaum RR, Yamini B. DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-?B p50 and a single nucleotide in the ?B-site. Nucleic Acids Res. 2013 Jan; 41(2):764-74. PMID: 23180782; PMCID: PMC3553961.
      Citations: 16     Fields:    Translation:AnimalsCells
    36. Dey M, Daniel S, Wong RH, Smith SM, Yamini B. Marginal zone lymphoma of the thoracic dura causing spinal cord compression. J Clin Neurosci. 2013 Jan; 20(1):171-3. PMID: 22989787.
      Citations: 3     Fields:    Translation:Humans
    37. Schmitt AM, Crawley CD, Kang S, Raleigh DR, Yu X, Wahlstrom JS, Voce DJ, Darga TE, Weichselbaum RR, Yamini B. p50 (NF-?B1) is an effector protein in the cytotoxic response to DNA methylation damage. Mol Cell. 2011 Dec 09; 44(5):785-96. PMID: 22152481; PMCID: PMC3240852.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    38. Rosen DS, Smith S, Gurbuxani S, Yamini B. Extranodal hairy cell leukemia presenting in the lumbar spine. J Neurosurg Spine. 2008 Oct; 9(4):374-6. PMID: 18939925.
      Citations: 6     Fields:    Translation:Humans
    39. Rosen DS, Shafizadeh S, Baroody FM, Yamini B. Epidural abscess treated with a medial supraorbital craniotomy through an incision in the eyebrow. Case report. J Neurosurg Pediatr. 2008 Feb; 1(2):145-7. PMID: 18352786.
      Citations: 2     Fields:    Translation:Humans
    40. Ferguson SD, Foster K, Yamini B. Convection-enhanced delivery for treatment of brain tumors. Expert Rev Anticancer Ther. 2007 Dec; 7(12 Suppl):S79-85. PMID: 18076322.
      Citations: 12     Fields:    Translation:HumansAnimals
    41. Yamini B, Yu X, Pytel P, Galanopoulos N, Rawlani V, Veerapong J, Bickenbach K, Weichselbaum RR. Adenovirally delivered tumor necrosis factor-alpha improves the antiglioma efficacy of concomitant radiation and temozolomide therapy. Clin Cancer Res. 2007 Oct 15; 13(20):6217-23. PMID: 17947489.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    42. Yamini B, Yu X, Dolan ME, Wu MH, Darga TE, Kufe DW, Weichselbaum RR. Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding. Cancer Res. 2007 Jul 15; 67(14):6889-98. PMID: 17638900.
      Citations: 20     Fields:    Translation:HumansCells
    43. Sikorski CW, Iteld L, McKinnon M, Yamini B, Frim DM. Correction of sagittal craniosynostosis using a novel parietal bone fixation technique: results over a 10-year period. Pediatr Neurosurg. 2007; 43(1):19-24. PMID: 17190983.
      Citations: 2     Fields:    Translation:Humans
    44. Sikorski CW, Pytel P, Rubin CM, Yamini B. Intradural spinal Wilm's tumor metastasis: case report. Neurosurgery. 2006 Oct; 59(4):E942-3; discussion E943. PMID: 17038931.
      Citations: 3     Fields:    Translation:Humans
    45. Yamini B, Narayanan M. Craniopharyngiomas: an update. Expert Rev Anticancer Ther. 2006 Sep; 6 Suppl 9:S85-92. PMID: 17004862.
      Citations: 8     Fields:    Translation:Humans
    46. Mezhir JJ, Smith KD, Posner MC, Senzer N, Yamini B, Kufe DW, Weichselbaum RR. Ionizing radiation: a genetic switch for cancer therapy. Cancer Gene Ther. 2006 Jan 01; 13(1):1-6. PMID: 16082378.
      Citations: 10     Fields:    Translation:HumansCells
    47. Yamini B, Sikorski CW. Surgery for low-grade gliomas: current evidence and controversies. Expert Rev Neurother. 2005 Nov; 5(6 Suppl):S13-9. PMID: 16274266.
      Citations:    Fields:    Translation:Humans
    48. Mezhir JJ, Schmidt H, Yamini B, Senzer NN, Posner MC, Kufe DW, Weichselbaum RR. Chemo-inducible gene therapy. Anticancer Drugs. 2005 Nov; 16(10):1053-8. PMID: 16222146.
      Citations: 2     Fields:    Translation:HumansCells
    49. Lee MC, Yamini B, Frim DM. Pseudotumor cerebri patients with shunts from the cisterna magna: clinical course and telemetric intracranial pressure data. Neurosurgery. 2004 Nov; 55(5):1094-9. PMID: 15509316.
      Citations: 5     Fields:    Translation:Humans
    50. Yamini B, Yu X, Gillespie GY, Kufe DW, Weichselbaum RR. Transcriptional targeting of adenovirally delivered tumor necrosis factor alpha by temozolomide in experimental glioblastoma. Cancer Res. 2004 Sep 15; 64(18):6381-4. PMID: 15374943.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    51. Yamini B, Refai D, Rubin CM, Frim DM. Initial endoscopic management of pineal region tumors and associated hydrocephalus: clinical series and literature review. J Neurosurg. 2004 May; 100(5 Suppl Pediatrics):437-41. PMID: 15287451.
      Citations: 35     Fields:    Translation:Humans
    52. Sikorski CW, Yamini B, Frim DM. Endoscopic cyst fenestration outcomes in children one year of age or less. Pediatr Neurosurg. 2004 Mar-Apr; 40(2):59-63. PMID: 15292634.
      Citations: 3     Fields:    Translation:Humans
    53. Le H, Yamini B, Frim DM. Lumboperitoneal shunting as a treatment for slit ventricle syndrome. Pediatr Neurosurg. 2002 Apr; 36(4):178-82. PMID: 12006752.
      Citations: 16     Fields:    Translation:Humans
    54. Zhang ZD, Yamini B, Komuro T, Ono S, Johns L, Marton LS, Weir B, Macdonald RL, Zhang ZD, Yamini B, Komuro T, Ono S, Johns L, Marton LS, Weir B, Macdonald RL. Vasospasm in monkeys resolves because of loss of and encasement of subarachnoid blood clot. Stroke. 2001 Aug; 32(8):1868-74. PMID: 11486119.
      Citations: 9     Fields:    Translation:Animals
    55. Yamini B, Loch Macdonald R, Rosenblum J, Yamini B, Loch Macdonald R, Rosenblum J. Treatment of deep cerebral venous thrombosis by local infusion of tissue plasminogen activator. Surg Neurol. 2001 Jun; 55(6):340-6. PMID: 11483188.
      Citations: 10     Fields:    Translation:Humans
    56. Macdonald RL, Ono S, Johns L, Marton LS, Weir B, Zhang ZD, Yamini B, Komuro T, Ahmed I, Stoodley M. Molecular weight interactions in experimental vasospasm. Acta Neurochir Suppl. 2001; 77:115-7. PMID: 11563267.
      Citations:    Fields:    Translation:Animals
    57. Zhang ZD, Yamini B, Komuro T, Ono S, Johns L, Marton LS, Weir B, Macdonald RL. Delayed clot removal and experimental vasospasm. Acta Neurochir Suppl. 2001; 77:33-5. PMID: 11563304.
      Citations: 1     Fields:    Translation:Animals
    58. Ono S, Zhang ZD, Marton LS, Yamini B, Windmeyer E, Johns L, Kowalczuk A, Lin G, Macdonald RL. Heme oxygenase-1 and ferritin are increased in cerebral arteries after subarachnoid hemorrhage in monkeys. J Cereb Blood Flow Metab. 2000 Jul; 20(7):1066-76. PMID: 10908040.
      Citations: 7     Fields:    Translation:Animals
    59. Yamini B, Goumnerova LC, Frim DM. Endoscopic approach to noncommunicating fluid spaces in the shunted patient. Pediatr Neurosurg. 1999 Nov; 31(5):237-41. PMID: 10681677.
      Citations:    Fields:    Translation:Humans
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