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Wei Wei

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    How are neural circuits assembled to perform specific computations? An excellent model system to address this question is the retina, where a diverse set of neural circuits are wired with remarkable precision and intricacy to extract salient features such as color, contrast and motion from the visual scene. Each retinal circuit utilizes distinct neuronal types and conveys the processed visual information to higher brain by a specific type of retinal ganglion cells.

    My lab is interested in the synaptic basis of neural computation in the retina. Our current research is focused on understanding the developmental and adult patterns of synaptic connections underlying the retinal circuits, and determining how the specific wiring patterns impact visual processing. We leverage the increasing repertoire of genetic tools that label specific retinal neuron types to target the synapses of interest, and characterize the maturation and function of these synapses using a combination of techniques including multiphoton microscopy, visual stimulation, electrophysiology and molecular biology. These studies will provide insight into the neural mechanisms of visual processing in the retina, and also have broader implications in the fundamental questions of synapse development and organization in the central nervous system.

    Collapse Biography 
    Collapse education and training
    Cold Spring Harbor Laboratory, New YorkPhD2008Neurobiology
    University of California, Berkeley, CaliforniaPostdoctoral training2011Neurobiology
    Collapse awards and honors
    2012Whitehall Foundation Grant
    2013Sloan Research Fellowship
    2013E. Matilda Ziegler Foundation Grant
    2014Karl Kirchgessner Foundation Grant
    2016McKnight Scholar Award

    Collapse Research 
    Collapse research activities and funding
    R01NS109990     (WEI, WEI)Sep 30, 2018 - Jul 31, 2024
    Circuit mechanisms for encoding naturalistic motion in the mammalian retina
    Role: Principal Investigator

    R01EY024016     (WEI, WEI)Jan 1, 2014 - Dec 31, 2019
    Synaptic basis of motion detection in the retina
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Deng Y, Pacheco JA, Ghosh A, Chung A, Mao C, Smith JC, Zhao J, Wei WQ, Barnado A, Dorn C, Weng C, Liu C, Cordon A, Yu J, Tedla Y, Kho A, Ramsey-Goldman R, Walunas T, Luo Y. Natural language processing to identify lupus nephritis phenotype in electronic health records. BMC Med Inform Decis Mak. 2024 Mar 03; 22(Suppl 2):348. PMID: 38433189; PMCID: PMC10910523.
      Citations:    Fields:    Translation:Humans
    2. Acarón Ledesma H, Ding J, Oosterboer S, Huang X, Chen Q, Wang S, Lin MZ, Wei W. Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells. Nat Commun. 2024 Feb 28; 15(1):1819. PMID: 38418467; PMCID: PMC10901804.
      Citations:    Fields:    Translation:AnimalsCells
    3. Jiang Q, Litvina EY, Acarón Ledesma H, Shu G, Sonoda T, Wei W, Chen C. Functional convergence of on-off direction-selective ganglion cells in the visual thalamus. Curr Biol. 2022 07 25; 32(14):3110-3120.e6. PMID: 35793680; PMCID: PMC9438454.
      Citations: 3     Fields:    Translation:AnimalsCells
    4. Huang X, Kim AJ, Acarón Ledesma H, Ding J, Smith RG, Wei W. . Visual stimulation induces distinct forms of sensitization of On-Off direction-selective ganglion cell responses in the dorsal and ventral retina. J Neurosci. 2022; 22(42):4449-69. View Publication.
    5. Ding J, Chen A, Chung J, Acaron Ledesma H, Wu M, Berson DM, Palmer SE, Wei W. Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit. Elife. 2021 06 07; 10. PMID: 34096504; PMCID: PMC8211448.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Fang Y, Prominski A, Rotenberg MY, Meng L, Lv Y, Yue J, Schaumann E, Jeong J, Yamamoto N, Jiang Y, Elbaz B, Wei W, Tian B, Acarón Ledesma H. Micelle-enabled self-assembly of porous and monolithic carbon membranes for bioelectronic interfaces. Nat Nanotechnol. 2021 02; 16(2):206-213. PMID: 33288948; PMCID: PMC8801202.
      Citations: 7     Fields:    
    7. Chen Q, Smith RG, Huang X, Wei W. Preserving inhibition with a disinhibitory microcircuit in the retina. Elife. 2020 12 03; 9. PMID: 33269700; PMCID: PMC7728437.
      Citations: 5     Fields:    Translation:AnimalsCells
    8. Ding J, Wei W. Dampening light sensitivity. Science. 2020 05 01; 368(6490):471-472. PMID: 32355019.
      Citations:    Fields:    Translation:HumansCells
    9. Wei W. Decreasing Influence of Retinal Inputs on the Developing Visual Cortex. Neuron. 2019 11 20; 104(4):629-631. PMID: 31751542.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Li X, Wei W, Bezanilla F, Tian B, Acarón Ledesma H, Carvalho-de-Souza JL. An atlas of nano-enabled neural interfaces. Nat Nanotechnol. 2019 07; 14(7):645-657. PMID: 31270446; PMCID: PMC6800006.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    11. Huang X, Rangel M, Briggman KL, Wei W. Neural mechanisms of contextual modulation in the retinal direction selective circuit. Nat Commun. 2019 06 03; 10(1):2431. PMID: 31160566; PMCID: PMC6547848.
      Citations: 14     Fields:    Translation:AnimalsCells
    12. Wei W. Neural Mechanisms of Motion Processing in the Mammalian Retina. Annu Rev Vis Sci. 2018 09 15; 4:165-192. PMID: 30095374.
      Citations: 37     Fields:    Translation:AnimalsCells
    13. Chen Q, Wei W. Stimulus-dependent engagement of neural mechanisms for reliable motion detection in the mouse retina. J Neurophysiol. 2018 09 01; 120(3):1153-1161. PMID: 29897862; PMCID: PMC6171070.
      Citations: 6     Fields:    Translation:AnimalsCells
    14. Wei W. Compartmentalized dendritic signaling in a multitasking retinal interneuron. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11268-11270. PMID: 29073042; PMCID: PMC5664561.
      Citations:    Fields:    Translation:Cells
    15. Koren D, Grove JCR, Wei W. Cross-compartmental Modulation of Dendritic Signals for Retinal Direction Selectivity. Neuron. 2017 Aug 16; 95(4):914-927.e4. PMID: 28781167; PMCID: PMC5572825.
      Citations: 27     Fields:    Translation:AnimalsCells
    16. Shi X, Barchini J, Ledesma HA, Koren D, Jin Y, Liu X, Wei W, Cang J. Retinal origin of direction selectivity in the superior colliculus. Nat Neurosci. 2017 Apr; 20(4):550-558. PMID: 28192394; PMCID: PMC5374021.
      Citations: 41     Fields:    Translation:AnimalsCells
    17. Chen Q, Pei Z, Koren D, Wei W. Stimulus-dependent recruitment of lateral inhibition underlies retinal direction selectivity. Elife. 2016 12 08; 5. PMID: 27929372; PMCID: PMC5176353.
      Citations: 31     Fields:    Translation:AnimalsCells
    18. Pei Z, Chen Q, Koren D, Giammarinaro B, Acaron Ledesma H, Wei W. Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina. J Neurosci. 2015 Sep 23; 35(38):13219-32. PMID: 26400950; PMCID: PMC4579379.
      Citations: 46     Fields:    Translation:AnimalsCells
    19. Triplett JW, Wei W, Gonzalez C, Sweeney NT, Huberman AD, Feller MB, Feldheim DA. Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits. Neural Dev. 2014 Feb 05; 9:2. PMID: 24495295; PMCID: PMC3937143.
      Citations: 34     Fields:    Translation:AnimalsCells
    20. Wei W, Feller MB. Organization and development of direction-selective circuits in the retina. Trends Neurosci. 2011 Dec; 34(12):638-45. PMID: 21872944; PMCID: PMC4538999.
      Citations: 42     Fields:    Translation:HumansCells
    21. Rivlin-Etzion M, Zhou K, Wei W, Elstrott J, Nguyen PL, Barres BA, Huberman AD, Feller MB. Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing. J Neurosci. 2011 Jun 15; 31(24):8760-9. PMID: 21677160; PMCID: PMC3139540.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    22. Wei W, Hamby AM, Zhou K, Feller MB. Development of asymmetric inhibition underlying direction selectivity in the retina. Nature. 2011 Jan 20; 469(7330):402-6. PMID: 21131947; PMCID: PMC3974627.
      Citations: 115     Fields:    Translation:AnimalsCells
    23. Wei W, Elstrott J, Feller MB. Two-photon targeted recording of GFP-expressing neurons for light responses and live-cell imaging in the mouse retina. Nat Protoc. 2010 Jul; 5(7):1347-52. PMID: 20595962; PMCID: PMC4303237.
      Citations: 55     Fields:    Translation:AnimalsCells
    24. Wei W, Nguyen LN, Kessels HW, Hagiwara H, Sisodia S, Malinow R. Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat Neurosci. 2010 Feb; 13(2):190-6. PMID: 20037574; PMCID: PMC3310198.
      Citations: 191     Fields:    Translation:AnimalsCells
    25. Huberman AD, Wei W, Elstrott J, Stafford BK, Feller MB, Barres BA. Genetic identification of an On-Off direction-selective retinal ganglion cell subtype reveals a layer-specific subcortical map of posterior motion. Neuron. 2009 May 14; 62(3):327-34. PMID: 19447089; PMCID: PMC3140054.
      Citations: 213     Fields:    Translation:AnimalsCells
    26. Kopec CD, Li B, Wei W, Boehm J, Malinow R. Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation. J Neurosci. 2006 Feb 15; 26(7):2000-9. PMID: 16481433; PMCID: PMC6674938.
      Citations: 256     Fields:    Translation:AnimalsCells
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