Loading...
The University of Chicago Header Logo
Keywords
Last Name
Institution

WEI WEI

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentNeurobiology
AddressChicago IL 60637
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    How are neural circuits assembled to perform specific computations? An excellent model system to address this question is the retina, where a diverse set of neural circuits are wired with remarkable precision and intricacy to extract salient features such as color, contrast and motion from the visual scene. Each retinal circuit utilizes distinct neuronal types and conveys the processed visual information to higher brain by a specific type of retinal ganglion cells.

    My lab is interested in the synaptic basis of neural computation in the retina. Our current research is focused on understanding the developmental and adult patterns of synaptic connections underlying the retinal circuits, and determining how the specific wiring patterns impact visual processing. We leverage the increasing repertoire of genetic tools that label specific retinal neuron types to target the synapses of interest, and characterize the maturation and function of these synapses using a combination of techniques including multiphoton microscopy, visual stimulation, electrophysiology and molecular biology. These studies will provide insight into the neural mechanisms of visual processing in the retina, and also have broader implications in the fundamental questions of synapse development and organization in the central nervous system.


    Collapse Biography 
    Collapse education and training
    Cold Spring Harbor Laboratory, New YorkPhD2008Neurobiology
    University of California, Berkeley, CaliforniaPostdoctoral training2011Neurobiology
    Collapse awards and honors
    2012Whitehall Foundation Grant
    2013Sloan Research Fellowship
    2013E. Matilda Ziegler Foundation Grant
    2014Karl Kirchgessner Foundation Grant
    2016McKnight Scholar Award

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wei W. Neural Mechanisms of Motion Processing in the Mammalian Retina. Annu Rev Vis Sci. 2018 Sep 15; 4:165-192. PMID: 30095374.
      View in: PubMed
    2. Chen Q, Wei W. Stimulus-dependent engagement of neural mechanisms for reliable motion detection in the mouse retina. J Neurophysiol. 2018 Sep 01; 120(3):1153-1161. PMID: 29897862.
      View in: PubMed
    3. Wei W. Compartmentalized dendritic signaling in a multitasking retinal interneuron. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11268-11270. PMID: 29073042.
      View in: PubMed
    4. Koren D, Grove JCR, Wei W. Cross-compartmental Modulation of Dendritic Signals for Retinal Direction Selectivity. Neuron. 2017 Aug 16; 95(4):914-927.e4. PMID: 28781167.
      View in: PubMed
    5. Li S, Dou X, Ning H, Song Q, Wei W, Zhang X, Shen C, Li J, Sun C, Song Z. Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity. Hepatology. 2017 09; 66(3):936-952. PMID: 28437863.
      View in: PubMed
    6. Shi X, Barchini J, Ledesma HA, Koren D, Jin Y, Liu X, Wei W, Cang J. Retinal origin of direction selectivity in the superior colliculus. Nat Neurosci. 2017 Apr; 20(4):550-558. PMID: 28192394.
      View in: PubMed
    7. Chen Q, Pei Z, Koren D, Wei W. Stimulus-dependent recruitment of lateral inhibition underlies retinal direction selectivity. Elife. 2016 Dec 08; 5. PMID: 27929372.
      View in: PubMed
    8. Pei Z, Chen Q, Koren D, Giammarinaro B, Acaron Ledesma H, Wei W. Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina. J Neurosci. 2015 Sep 23; 35(38):13219-32. PMID: 26400950.
      View in: PubMed
    9. Volk A, Li J, Xin J, You D, Zhang J, Liu X, Xiao Y, Breslin P, Li Z, Wei W, Schmidt R, Li X, Zhang Z, Kuo PC, Nand S, Zhang J, Chen J, Zhang J. Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML. J Exp Med. 2014 Jun 02; 211(6):1093-108. PMID: 24842373; PMCID: PMC4042653.
    10. Triplett JW, Wei W, Gonzalez C, Sweeney NT, Huberman AD, Feller MB, Feldheim DA. Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits. Neural Dev. 2014 Feb 05; 9:2. PMID: 24495295.
      View in: PubMed
    11. Kho AN, Hayes MG, Rasmussen-Torvik L, Pacheco JA, Thompson WK, Armstrong LL, Denny JC, Peissig PL, Miller AW, Wei WQ, Bielinski SJ, Chute CG, Leibson CL, Jarvik GP, Crosslin DR, Carlson CS, Newton KM, Wolf WA, Chisholm RL, Lowe WL. Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study. J Am Med Inform Assoc. 2012 Mar-Apr; 19(2):212-8. PMID: 22101970; PMCID: PMC3277617.
    12. Wei W, Feller MB. Organization and development of direction-selective circuits in the retina. Trends Neurosci. 2011 Dec; 34(12):638-45. PMID: 21872944.
      View in: PubMed
    13. Rivlin-Etzion M, Zhou K, Wei W, Elstrott J, Nguyen PL, Barres BA, Huberman AD, Feller MB. Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing. J Neurosci. 2011 Jun 15; 31(24):8760-9. PMID: 21677160.
      View in: PubMed
    14. Wei W, Hamby AM, Zhou K, Feller MB. Development of asymmetric inhibition underlying direction selectivity in the retina. Nature. 2011 Jan 20; 469(7330):402-6. PMID: 21131947.
      View in: PubMed
    15. Wei W, Elstrott J, Feller MB. Two-photon targeted recording of GFP-expressing neurons for light responses and live-cell imaging in the mouse retina. Nat Protoc. 2010 Jul; 5(7):1347-52. PMID: 20595962.
      View in: PubMed
    16. Wei W, Nguyen LN, Kessels HW, Hagiwara H, Sisodia S, Malinow R. Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat Neurosci. 2010 Feb; 13(2):190-6. PMID: 20037574.
      View in: PubMed
    17. Huberman AD, Wei W, Elstrott J, Stafford BK, Feller MB, Barres BA. Genetic identification of an On-Off direction-selective retinal ganglion cell subtype reveals a layer-specific subcortical map of posterior motion. Neuron. 2009 May 14; 62(3):327-34. PMID: 19447089.
      View in: PubMed
    18. Kopec CD, Li B, Wei W, Boehm J, Malinow R. Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation. J Neurosci. 2006 Feb 15; 26(7):2000-9. PMID: 16481433.
      View in: PubMed
    WEI's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _